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Tag: "out" at biology news

Mouse brain cells rapidly recover after Alzheimer's plaques are cleared

...med to be wellestablished and stable, but clearing out the plaques often led to rapidrecovery of normal structure over a few days," says senior author DavidH. Holtzman, M.D., the Charlotte and Paul Hagemann Professor and headof the Department of Neurology. "This provides confirmation of thepotential bene...

Key molecule in plant photo-protection identified

...med to be wellestablished and stable, but clearing out the plaques often led to rapidrecovery of normal structure over a few days," says senior author DavidH. Holtzman, M.D., the Charlotte and Paul Hagemann Professor and headof the Department of Neurology. "This provides confirmation of thepotential bene...

Researchers Uncover Key Step In Manufacture of Memory Protein

... conversion to mBDNF. Instead, it appeared to leak out of the golgi apparatus, where it leached through the cell membrane without first having been converted to active mBDNF. Because they cannot make mBDNF, CPE-deficient mice have poor long-term memory. Dr. Loh added that, in the near future, an underst...

Novel antiviral technology inhibits RSV infection in mice

...wn as RNAinterference, or gene silencing, to knock out one of the key proteinsneeded for RSV to multiply in the lungs. The virus harnesses thisprotein, known as NS1, to block the body's own antiviral response,which would normally kill RSV before it could gain a foothold."This is an exciting advance in th...

Study Demonstrates Gene Expression Microarrays are Comparable and Reproducible

...e of microarrays may requirelarger studies carried out in multiple locations and would necessitatethat mi...dedtechnical assistance to the four sites carrying out the study. ArdaisCorporation, Lexington, Mass., provided the RNA samples used foranalysis....

Computers to be used to find blueprint for new influenza drug

...s. The three-year project will be largely carried out by examining the behaviour of atoms of the influenza virus which attack cells, and atoms of the throat cells that are attacked. By using advanced software to model the way these atoms behave in highly complex interactions, the atomic structure of a s...

Ecological destruction fuels emerging diseases

... change or mass extinction, and species have moved out of their areas of origin into other areas, there h...mic information about parasites, Dr. Brooks points out that we lack the ability to predict and thus prevent emerging parasitic diseases. "Right now, we're...

A much-needed shot in the arm for HIV vaccine development

...asclaimed more than twenty million lives and wiped out decades ofdevelopment gains," said Pascoal Mocumbi, "I do believe that thisscientific strategic plan will not only accelerate the development of alifesaving HIV vaccine but also boost African capacity in healthresearch to address new health threats."...

Newly discovered virus linked to childhood lung disorders and Kawasaki disease

...sm about the present findings, Dr. McIntoshpointed out some "tantalizing facts": onset of Kawasaki disease isoften preceded by a respiratory syndrome; both the disease andrespiratory coronavirus infections are seasonal, peaking in the winterand spring; recent studies have described a powerful immune resp...

New Technique for Tracking Gene Regulators

Finding out where gene-regulator proteinsbind to DNA and identifying the genes they regulate just got a stepeasier thanks to a new technique developed by scientists at the U.S.Department of Energy’s Brookhaven National Laboratory. The techniquecould greatly spee...

Bacteria collection sheds light on urinary tract infections

...according to a team of bacteriologists. “We found out that UTIs may be caused by ingesting food contamin...d have been difficult for the researchers to carry out the research, according to DebRoy. The Gastroenteric Disease Center has been collecting E.coli sampl...

Combination therapy boosts effectiveness of telomere-directed cancer cell death

...the project? Look for somethingelse? Hell no! Look out for whats stopping the drug! Perseverance issometimes worth it, as we can see .A new research study published in the January issue of Cancer Cellprovides exciting new information about how to boost the effectivenessof a promising cancer treatment tha...

GATA: a graphic alignment tool for comparative sequence analysis

...the project? Look for somethingelse? Hell no! Look out for whats stopping the drug! Perseverance issometimes worth it, as we can see .A new research study published in the January issue of Cancer Cellprovides exciting new information about how to boost the effectivenessof a promising cancer treatment tha...

Genome-wide mouse study yields link to human leukemia

...ion," says Plass. "We are just beginning to figure out how it best works in humans, but simply knowing that we have a new target that may be meaningful in treating leukemia is a big step in the right direction." Grants from the National Cancer Institute and the Leukemia and Lymphoma Society supported th...

Iron Deficiency Sparks Dramatic Changes In Gene Expression

...iterally hundreds of proteinsrequire iron to carry out their proper function, so without thisnutrient, th...ranslate its genetic code into proteins that carry out itsintended functions.Thiele said the same scenario may occur in human cells, as well, to aneven gre...

Learning to fight an adversary that won't stay down

...atively small number of antibiotics that have come out that are new, and some of them are very potent and act against most resistant strains," he says. "But the clinicians rightly try to keep these things in reserve for when they are really needed." ...

Scientists find missing enzyme for tuberculosis iron scavenging pathway

...acquire the iron they need to grow ?it is secreted out into the external environment where it scavenges iron and then (with iron bound to it) it is taken up by the bacterium again." Although Rv1347c is not involved in antibiotic resistance, it still remains a target for the design of new anti-TB drugs. ...

Novel Enzyme Shows Potential As An Anti-HIV Target

...r machinery—including RNA polymerases, which carry out transcription—to copy its RNA genome into DNA and infiltrate human chromosomal DNA. Once the virus is integrated (now called a provirus), its genes can be transcribed. Adept as HIV is in exploiting its host’s molecular resources, the virus can’t est...

Scientists seek answers on what activates deadly anthrax spores

...al Center and three other institutions are setting out to find what activates the spores in anthrax, the ...new details on how anthrax develops, but also pick out structural vulnerabilities that are key to designing new therapeutic agents to prevent anthrax. Int...

NYU Study Reveals How Brain's Immune System Fights Viral Encephalitis

...outbreak in the northeast. The NYU researchers set out to determine how the body can fight viral encephalitis. Specifically, they examined how type I interferons--proteins made by the body that are released in response to stimuli, notably infection--work in neurons and to determine if nerve cells' respon...

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