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DNA Molecules Used To Assemble Nanoparticles

...sed cell, either killing it from within or sending out a signal to identify it. But making the particles is notoriously difficult and time-consuming. The nanoparticle system used by Baker's lab is based on dendrimers, star-like synthetic polymers that can carry a vast array of molecules on the ends of t...

Bioartificial kidney under study at MCG

...ed back into the body. The stuff that isn't pumped out is just like urine: it goes in the toilet," Dr. Szerlip says. Preliminary findings on 10 patients at the University of Michigan Medical Center and Cleveland Clinic Foundation showed the device was safe and produced desired results such as reducing c...

Wisconsin scientists grow critical nerve cells

...tep in the process? The hunch paid off and turned out to be the final piece of the puzzle. The discovery, says Zhang, demonstrates that human stem cells do not necessarily differentiate in linear fashion, as scientists always believed. Rather, a series of complex overlapping changes may well be the dev...

Jump-starting T Cells In Skin Cancer

...ment of the tumor such that other T cells can snap out of their stupor and attack the tumor. ...

Scientists ID molecular 'switch' in liver that triggers harmful effects of saturated and trans fats

...do their dirty work," said Spiegelman, who carries out basic research on fat cells and metabolic pathways in diabetes and cancer at Dana-Farber. "It offers the opportunity to try to understand what makes these fatty acids so deleterious, and what we need to avoid." Moreover, it is possible that in the f...

A new mechanism of regulating RNA degradation

...at naturally interact with the bait will be pulled out of the pool of cellular proteins. They found that Upf1 grabbed onto Staufen1 (Stau1). Stau1 is a well-known RNA binding protein and some of its functions in the common fruit fly Drosophila are understood. "But no one knew what Staufen1 did in human ...

FDA Approves Human Hookworm Vaccine for Phase I Safety Trials

...at naturally interact with the bait will be pulled out of the pool of cellular proteins. They found that Upf1 grabbed onto Staufen1 (Stau1). Stau1 is a well-known RNA binding protein and some of its functions in the common fruit fly Drosophila are understood. "But no one knew what Staufen1 did in human ...

UCSB scientists probe sea floor venting to gain understanding of early life on Earth

...t the need for drilling, making it easier to tease out what is living at depth in oceanic crust. The fluids that emerge may come in bursts when earthquakes occur; fluid flow may therefore repeat episodically over hundreds of thousands of years as abyssal hills are uplifted and spread away from the mid-oc...

UAB scientists discover the origin of a mysterious physical force

...are strongly orientated in such a way as to cancel out the electric field, and on some occasions, to reverse it. This abnormal behaviour was discovered by the same researchers and published in Physical Review Letters in April 2004. The scientists have now discovered that this strange property is respons...

Yellowstone microbes fueled by hydrogen, according to U. of Colorado study

...akes me wonder howmany different kinds of microbes out there are metabolizing hydrogen inextreme environm...ed computer-generated thermodynamic models to find out ifhydrogen was indeed the principle source of energy. "You can smellsulfide in the air at Yellowston...

It's not all genetic: Common epigenetic problem doubles cancer risk in mice

...ple, the current experiments were designed to find out whether the loss of imprinting is involved in cancer's development or just in its progression. "Most researchers, including me, expect epigenetic differences to influence progression -- whether a tumor would grow slowly or quickly, or whether it wou...

Columbia research lifts major hurdle to gene therapy for cancer

... may now be able to design a therapy that willseek out and destroy only cancer cells," said the study's seniorauthor, Paul B. Fisher, Ph.D., professor of clinical pathology andMichael and Stella Chernow Urological Cancer Research Scientist atColumbia University Medical Center. "We hope it will be particu...

Priming embryonic stem cells to fulfill their promise

...interesting interactions, andwe were able to tease out the effects of each protein, alone and incombination with others."Cell biologists have not performed such combinatorial assays for otherdesired cell types because they have no practical way to do so. Bhatia,Chien, and Flaim seized on the unique abili...

Growth in the sea comes down to a struggle for iron

...rapher Mark Wells. And diatoms may not always come out on top. In collaboration with a large Japanese re...rn Ocean around Antarctica, the equatorial Pacific out to about 140 degrees west and the sub-Arctic Pacific," says Wells. "The North Atlantic has a big spr...

New, automated tool successfully classifies and relates proteins in unprecedented way

...gieMellon. The computational analyses were carried out together with XiangChen, a graduate student in the Merck Computational Biology andChemistry program.Chen and Murphy found that the new tool outperformed existing methodsof identifying overlapping proteins within cells, such as simple visualcategoriza...

Lack of enzyme turns fat cells into fat burners

...etes."This adds another tissue or organ that helps out in the process ofenergy maintenance," said Wakil. "ACC2 is potentially a key enzyme inthe regulation of weight, obesity, and related problems."Wakil and his colleagues studied the oxidation of fatty acid andglucose in cultures of fat cells isolated f...

Poor prenatal nutrition permanently damages function of insulin-producing cells in the pancreas

...erol and other lipids. "The challenge is to figure out which factors are a primary cause of diabetes and ..., said Dr. Patti. "In our study, we needed to find out what was happening in these mice, before they got the problem." Their insulin levels provided a clu...

Emory Study Tests Bone Marrow Stem Cells to Improve Circulation in Legs

...eripheralvascular disease. Another goal is to find out whether or not increasingthe number of circulating...for whom those treatments are not options. To find out more about thestudy and eligibility, call 404-712-0170....

Controversial drug shown to act on brain protein to cut alcohol use

...er.In their research, the scientists first carried out classic behavioralstudies showing that Ibogaine reduced alcohol consumption. They inducedthe rats to consume alcohol in daily drinking sessions and thendemonstrated that their drinking declined precipitously when theyreceived Ibogaine. The drug was a...

UCLA Study Shows One-Third of Drug Ads in Medical Journals Do Not Contain References Supporting Medical Claims

...blications for comparison. Researchers found that out of 438 pharmaceutical ads, 126 (29 percent) offere...aceutical companies. The companies responded to 37 out of 88 requests for data-on-file, but more than half of the responses indicated that the information ...

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