Tag: "osteoarthritis" at biology news
Experimental gene therapy 'abolishes' arthritis pain and lessens joint damage
...ey are the first genetically engineered to develop osteoarthritis
like humans, with the same genetic predisposition that makes some more likely to develop the disease, the authors said. If all goes well with a follow-up study currently underway, researchers will apply to the U.S. Food and Drug Administration for pe...
Cartilage discovery offers arthritis hope
...l provide clues to how the crippling joint disease osteoarthritis
might one day be treated. The disease, which affe...facts that could prove useful in future studies on osteoarthritis
and related conditions." The next stage of the team's work will be to determine the structure of t...
Osteoarthritis may be sign of faster 'biological ageing'
...re taken of all participants to check for signs of osteoarthritis
and a blood sample was taken to assess "biological...sity, age, sex, and smoking. All those with hand osteoarthritis
were over 50, and the amount of telomere shortening was equivalent to that accrued over 11 years in ...
New engineered drug may offer prolonged arthritis relief
...the population continues to rise, the incidence of osteoarthritis
will increase. Osteoarthritis had been attribute...enter, for focusing on IL-1 as a major mediator of osteoarthritis
in the joint. Given the immune system's suspected role in osteoarthritis, scientists have suspecte...
Gene therapy research switches off joint inflammation; switches on genetic process of joint repair
...d functional assessments in subjects with moderate osteoarthritis
of the knee. Prior to this clinical investigation Reparagen was found to be the first natural product to "silence" genes that promote joint damage while simultaneously activating the repair gene, IGF-1, in human chondrocytes.2 The clinical study b...
Bioengineered tissue implants regenerate damaged knee cartilage
... be effectively repaired by tissue engineering and osteoarthritis
does not stop the regeneration process concludes r...including in some patients with pre-existing early osteoarthritis
of the knee secondary to traumatic injury. Maturation of the implanted, tissue-engineered cartilage...
Matrilin-3 gene discovered to prevent onset of osteoarthritis
A gene that is associated with osteoarthritis
and skeletal deformities in people has been shown to be responsible for preventing the onset of osteoarthritis
in adult mice, according to a recent study led by Rhode Island Hospital. The matrilin-3 gene plays a...
New genes implicated in rheumatoid arthritis
...ene expression in synovial tissue of patients with osteoarthritis
(OA). Between the disease-discordant twins, minor yet measurable differences were detected in the expression of 1,163 transcripts, representing 827 uniquely name...
Obese people are more sensitive to pain, suggests study
...ll of the older adults who completed the study had osteoarthritis
of the knee, a disease that causes inflammation an...ssive relaxation techniques would help people with osteoarthritis
to better cope with the pain that the disease can cause. Also called degenerative joint disease, ost...
Results of world's first gene therapy trial for arthritis show approach safe, feasible
...hope to conduct additional clinical trials in both osteoarthritis
and rheumatoid arthritis using AAV to transport the gene. In addition to Drs. Evans and Robbins, other authors are James H. Herndon, M.D., also now at Harvard; Steven C. Ghivizzani, Ph.D., now at the University of Florida; Mary Chester Wasko, M.D., ...
Arthritis: What Wnt wrong?
...al knee replacement for rheumatoid arthritis (RA), osteoarthritis
(OA), or non-arthritic injury. Using several molecular methods, Wakitani's group identified Wnt-7b and -10a as genes that were significantly upregulated in the arthritic knee tissues. However, protein expression studies revealed that only Wnt-7b was...