Researchers find promising cancer-fighting power of synthetic cell-signaling molecule
...ered orally and appear in often-difficult-to reach organs such as the prostate. "This is what suggested to us that Enigmols should be tested against other cancer types," Merrill explained. Subsequently, the researchers found that Enigmols suppress the growth of human prostate tumors implanted in mice, whic...Could microbes solve Russia's chemical weapons conundrum?
...vere damage to the respiratory system and internal organs if ingested or inhaled. It accounts for around 2 percent of Russia's CWA stockpile. Around 60 percent of the mustard RM consists of derivatives of a toxic compound called 1,4-perhydrothiazine (PHT). Ermakova's research team grew P putida in culture...Molecular thermometers on skin cells detect heat and camphor
...ystem of sensory neurons that connect the brain to organs like the eye, ear, nose, and mouth. In recent years, biologists and neuroscientists have been trying to discover the basic molecules and mechanisms that underlie this complicated communication system that is our senses, and one group of researchers ...Future diabetes drugs may target new protein interaction
...od shortages; the brain and certain other critical organs rely on sugar -- specifically glucose -- for the energy to function. In people with diabetes, however, the liver doesn't sense the incoming calories, and it keeps making glucose when it shouldn't. The researchers discovered that, in fasting mice, th......od shortages; the brain and certain other critical organs rely on sugar -- specifically glucose -- for the energy to function. In people with diabetes, however, the liver doesn't sense the incoming calories, and it keeps making glucose when it shouldn't. The researchers discovered that, in fasting mice, th...Computational verification of protein-protein interactions by orthologous co-expression
...od shortages; the brain and certain other critical organs rely on sugar -- specifically glucose -- for the energy to function. In people with diabetes, however, the liver doesn't sense the incoming calories, and it keeps making glucose when it shouldn't. The researchers discovered that, in fasting mice, th...Eliminate Data Analysis Bottlenecks in Drug Discovery
...od shortages; the brain and certain other critical organs rely on sugar -- specifically glucose -- for the energy to function. In people with diabetes, however, the liver doesn't sense the incoming calories, and it keeps making glucose when it shouldn't. The researchers discovered that, in fasting mice, th...Gov't Creates Gene Database of Normal Human Tissues
...ch genes are expressed in many of the body's major organs under normal conditions, without known disease. S...samples of tissue from different parts of the same organs from multiple donors. Tissue samples were harvested an average of 11 hours after death, from males a...Precise Timing Enabled Pig-to-rat Transplants To Cure Diabetes
...g field of organogenesis, which focuses on growing organs from stem cells and other embryonic cell clusters known as organ primordia. Unlike embryonic stem cells, which can become virtually any cell type, primordia are locked into becoming a particular cell type or one of a particular set of cell types that...Active Vaccine Prevents Mice From Developing Prion Disease
...l be destroyed in the gut and will not reach other organs in the body." Because the research was conducted in normal mice, the NYU researchers say it will be easier to apply in animals in the wild, which are at risk for developing prion disease. Prion disease is contracted when an animal eats the body part...Vitamin A's paradoxical role in influencing symmetry during embryonic development revealed
... exterior of our bodies is symmetrical while inner organs are arranged asymmetrically. In research with zeb...r. "But, inside the human body, the pattern of the organs is asymmetrical. For example, we don't have two stomachs, one located on the right and the other on ...Studies reveal how plague disables immune system, and how to exploit the process to make a vaccine
... Two to three days later they harvested cells from organs where the bacteria tend to cluster. They used a dye to stain those cells green. When Y. pestis attacks a cell it uses the type-III pathway -- a needle-like projection -- to inject various toxins into the cell, killing it. The researchers endowed the...Mechanism for the captation of nutrients in plants- unknown to date
...ibuted around the plant), the cells of the reserve organs - such as roots, tubers, seeds or fruits - "swallow up" nutrients in order to metabolise and store them. These "swallowed-up" substances are incorporated into micro-vesicles that end up pouring their contents into an internal compartment of a vegetab...Researchers grow stem cells from human skin
...vide a valuable resource for tissue repair and for organs as well," said Anthony Atala, M.D., director of th...ue engineering ?the science of growing tissues and organs in the laboratory ?as well as in cell therapy. For cell therapy, laboratory-grown cells would be inj......cause its disruption can lead to cancer in various organs such as colon, lung, and breast. However, mounting evidence also points to its involvement in arthritic joint disease. Comprehensive analysis of the entire Wnt gene family in the progression of arthritis has been lacking until now. Researchers at Sh...New tool reveals secrets of migrating cells
...evelopmental immunologist. "In the past, we'd take organs out, smush them up and basically do biochemistry in test tubes, or watch their behavior in a single layer of cells. It's an imaging revolution to be able to go into the native environment while keeping the intact organ alive and make movies of migrat...Scientists find microRNAs regulate plant development
...nt life cycle - e.g. for leaves, roots, and floral organs to develop in the correct patterns and correct time sequence. Research reported in The Plant Cell shows that microRNAs control the accumulation of transcription factor proteins that regulate the expression of genes in the auxin response pathway. Mes...Discoveries by UAB and Florida scientists may help transplanted organs survive longer
...olecule that could delay rejection of transplanted organs by preventing blood-vessel deterioration. "One of the principal problems for kidney transplantation is organ availability," said Mark A. Atkinson, Ph.D., a study co-author and director of the Center for Immunology and Transplantation Research at UF....New type of rejection blocker protects kidneys after transplant
... belatacept should be able to protect transplanted organs from rejection without the toxicities associated w...y, considering that we have a critical shortage of organs for transplant," Vincenti said. Kidney transplant is the preferred treatment for most people with e...Most common lung cancers may begin in newly discovered cells
.... Patients in whom the disease has spread to other organs have a five-year survival rate of only two percent. In contrast, lung cancer detected at an early stage boasts a 50 percent survival rate over a five-year period. "There are many similarities between stem cells and cancer," said first author Carla B...