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A gene's first 'kiss' sets off that affair known as puberty

...ins, according to a study published in this week's online edition of the Proceedings of the National Academy of Sciences (PNAS). Until now, little had been known about what instigates the cascade of hormone secretions that, over time, produces puberty's tell-tale physical changes, including the developme...

Wisconsin scientists grow critical nerve cells

... the rest of the body. The new findings, reported online today (Jan. 30, 2005) in the journal Nature Biotechnology by scientists from the University of Wisconsin-Madison, are important because they provide critical guideposts for scientists trying to repair damaged or diseased nervous systems. Motor neur...

Spleen may be source of versatile stem cells

...t appears in the January 19 issue of SAGE KE , an online resource on the science of aging from the publishers of the journal Science. "Theremay be a previously undiscovered pocket of primitive stem cells in thespleen that are important for healing several types of damage orinjury," says Denise Faustman, M...

Researchers discover way to make cells in the eye sensitive to light

...g on a single gene.According to research published online today in Nature, the team fromImperial College London and the University of Manchester, havediscovered that activating the melanopsin gene in the nerve cellscauses them to become light responsive, or photoreceptive. Usingmouse cells, the researchers...

Yellowstone microbes fueled by hydrogen, according to U. of Colorado study

...the Yellowstonegeothermal system" this week in the online edition of the Proceedingsof the National Academy of Sciences.The team's findings, based on several years of research at the park,refute the popular idea that sulfur is the main source of energy fortiny organisms living in thermal features. "Itwas a...

It's not all genetic: Common epigenetic problem doubles cancer risk in mice

... this double protein dose as well. In the Feb. 24 online version of Science, the researchers report that mice engineered to have a double dose of insulin-like growth factor 2 (IGF2) develop more so-called precursor cells within the lining of the colon than normal mice. When these mice also carried a colon-...

Priming embryonic stem cells to fulfill their promise

...ary issue of Nature Methods,which became available online on Jan. 21. Embryonicstem cells are considered the blank-slate, raw material needed torepair or replace damaged or missing liver, nerve, muscle, and othertissues and organs. However, in order to fulfill their therapeuticpromise, scientists believe t...

Lack of enzyme turns fat cells into fat burners

...ege of Medicineresearchers.The report that appears online today in the Proceedings of the NationalAcademy of Sciences. "Westudied the fat cells in these mice bred to lack ACC2," said Dr. SalihWakil, chair of the BCM department of biochemistry and molecularbiology. "We found that the adipose in the mutant m...

Current human embryonic stem cell lines contaminated UCSD/Salk team finds

...titute in La Jolla,California.In a study published online January 23, 2005 in the journal NatureMedicine, the researchers found that human embryonic stem cells,including those currently approved for study under federal funding inthe U.S., contain a non-human, cell-surface sialic acid calledN-glycolylneurami...

Anti-bacterial additive widespread in U.S. waterways

...nderreported. The study ispublished in the current online edition of Environmental Science &Technology, a peer-reviewed journal of the American Chemical Society. "We'vebeen using triclocarban for almost half a century at rates approaching1 million pounds per year, but we have essentially no idea of wha...

Plants respond similarly to signals from friends, enemies

...n, North Carolina State University Date: Published online the week of Feb. 14 in Proceedings of the National Academy of Sciences ...

The secret to longevity in tubeworms

... a paper just published in the premier open-access online journal PLoS Biology, Erik Cordes and colleagues now provide a solution: by releasing its waste sulfate not up into the ocean but down into the sediments, L. luymesi stimulates the growth of sulfide-producing microbes, and ensures its own long-term s...

Scientists detect probable genetic cause of some Parkinson's disease cases

...an lead to the disease. The findings werepublished online by Lancet at 6:30 p.m. ET on January 17, 2004. Copiesof the studies will be made available to the media on January 17. Torequest copies, journalists should email pressoffice@lancet.com."Among the forms of Parkinson's disease that are genetic in origi...

A much-needed shot in the arm for HIV vaccine development

...e Enterprise'sscientific strategic plan, published online in the freely available,open-access global health journal PLoS Medicine.The Global HIV/AIDS Vaccine Enterprise is an international alliance ofindependent agencies and organizations conducting or supporting HIVvaccine research. In June 2004, the G8 co...

Genome-wide mouse study yields link to human leukemia

... he added. The findings appear in Nature Genetics online at http://www.nature.com/ng/. "This is the first time anyone has examined methylation in leukemia on a genome-wide basis in a mouse, and the findings offer important implications for patient care, since we know that methylation, which alters gene fu...

Found: Missing sequence of the human Y chromosome

...y. Their manuscript describing this work,published online today and in the February print issue of GenomeResearch (www.genome.org), presents the sequencing and analysis of 554kilobases of previously uncharacterized sequence from thepericentromeric region of the Y chromosome. This sequence contains a450-kilo...

Live Recombinant Adenovirus Vaccine Technique Explored

...ces are limited. Their research was made available online March 14, 2005, in advance of publication in the Proceedings of the National Academy of Sciences. “Many vaccines are expensive to manufacture, require trained personnel to administer and multiple doses to provide immunity, which is not feasible for ...

Gene therapy converts dead bone graft to new, living tissue

... and failing bone grafts. The findings were posted online Feb. 13 and will appear in the March 1 issue of Nature Medicine. The procedure, designed by a team led by Edward M. Schwarz, Ph.D., associate professor of orthopedics and of microbiology and immunology at the University of Rochester Medical Center, ...

Novel Therapy Tested in Mice Could Chase Away Cat Allergies

...t in the April issue of Nature Medicine, available online now. In the future, the investigators say, these promising results could lead to a new therapy not only for human cat allergies, but also possibly for severe food allergies such as those to peanuts. The National Institute of Allergy and Infectious D...

Female sex hormones play a vital role in defense against sexually transmitted diseases

...g problem clinically. The two studies were posted online on the Journal of Virology website this week and will be published in the Journal in the March issue. ...

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