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Tag: "oncogene" at biology news

High-throughput oncogene mutation detection in human cancers by mass spectrometry-based genotyping

Researchers have devised a new method to detect a spectrum of known gene mutations in a variety of cancer genes that they say is both sensitive and cost-effective. They say that if validated, this method of genotyping might ultimately be used in "real time" to match patients to available targeted therapies. . .. The technique, developed at the Dana-Farber Cancer Institute and the Broad Institute...

Scientists tie several cancers to common 'oncogene engine'

Researchers at Dana-Farber Cancer Institute report that a common "oncogene engine" ?a small family of malfunctioning cell growth switches ?drives several seemingly unrelated, lethal forms of cancer, including malignant melanoma. The finding suggests that it may be possible to attack these different cancers with the same therapy. . Reporting in the June issue of Cancer Cell, the scientists showed...

Pair of microRNA molecules controls major oncogene in most common leukemia

Researchers at Ohio State University have discovered that two microRNA (miRNA) molecules help control the oncogene responsible for a dangerous form of B-cell chronic lymphocytic leukemia (B-CLL), the most common human leukemia in the world. . .. In this case, high levels of two miRNAs known as miR-29 and miR-181 seem to suppress expression...
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