Genetic links could unlock clues to leading cause of blindness
...ors treat the disease before extensive vision loss occurs and may even prevent it in some people. The early risks associated with macular degeneration have been difficult for researchers to study in humans, and as a result, doctors know little about this aspect of the disease, Dawson said. "It's difficult ...Scientists take aim at virulent bacteria by decoding machinery of key control enzyme
... replication and repair. In humans DNA methylation occurs on the C (cytosine) rather than the A (adenine) nucleotide. Recently scientists have discovered a new role for Dam methylation. Dam also is essential for regulating the expression of genes responsible for bacterial virulence. When the gene responsib...Discovery of an American salamander where it shouldn't be: Korea
...o. "In the past, we have seen this one group that occurs in Sardinia and Italy as being somehow a special case, an enigmatic case," he said. "Now all of a sudden, we realize that if they're in Korea and they're in Italy, they must have been in between as well. There were probably plethodontid salamanders a...Scientists succeed in cloning human embryos from eggs matured in the lab
...I stage (MII) at which ovulation and fertilisation occurs in humans. However, there are few human MII oocytes available for research because almost all that are retrieved from women seeking fertility treatment are used to treat the patient. Immature oocytes are not used routinely for treatment at present, a...Invitrogen Launches i-Path -- A Unique Systems Biology Platform at BIO 2005
...I stage (MII) at which ovulation and fertilisation occurs in humans. However, there are few human MII oocytes available for research because almost all that are retrieved from women seeking fertility treatment are used to treat the patient. Immature oocytes are not used routinely for treatment at present, a...Novel plague virulence factor identified
...en Y. pestis and the worm is quite similar to what occurs in mammals, including humans. The work indicates that the pathogen may use similar virulence mechanisms to infect evolutionary disperse organisms. These findings are important, the researchers continued, since the pathogenesis system using the Caeno...New Look at DNA Hints at Origin of UV Damage
...en Y. pestis and the worm is quite similar to what occurs in mammals, including humans. The work indicates that the pathogen may use similar virulence mechanisms to infect evolutionary disperse organisms. These findings are important, the researchers continued, since the pathogenesis system using the Caeno...Drug Offers Alternative to Surgical Treatment After Miscarriage
...hors wrote that pregnancy failure, or miscarriage, occurs in 15 percent of pregnancies. With miscarriage, in some cases, a fetus dies in the womb, explained the study’s first author, Jun Zhang, M.D., Ph.D., an investigator in the Epidemiology Branch of NICHD’s Division of Epidemiology, Statistics, and Preve...Discoveries by UAB and Florida scientists may help transplanted organs survive longer
...munology and Transplantation Research at UF. "That occurs in part because after several years, people with kidney transplants often lose function of the organ. With about 60,000 people on the waiting list for a transplant, it would help immensely to find a way to reduce a patient's need for a second or thir...Sleeping Sickness Epidemic Spreading in Uganda
...hors wrote that pregnancy failure, or miscarriage, occurs in 15 percent of pregnancies. With miscarriage, in some cases, a fetus dies in the womb, explained the study’s first author, Jun Zhang, M.D., Ph.D., an investigator in the Epidemiology Branch of NICHD’s Division of Epidemiology, Statistics, and Preve...Unexpected lock and key mechanism found for the assembly of tumor blood vessels
...is active stage of blood vessel development, which occurs mainly in tumors in adults," said Varner. "This was a chance discovery, which was exciting, and we think it may have important clinical significance." In their current studies of breast cancer patients for the presence of the integrin and VCAM, "We ...Attacks of King George III's madness linked to key metabolism molecule
...nd high-carbohydrate diets on porphyria, they add, occurs because glucose causes the pancreas to make more insulin, which results in suppression of the PGC-1 alpha gene. The findings suggest that patients with porphyria should avoid any drugs or foods that turn on PGC-1 alpha activity in the liver, the res...Compound might defeat African sleeping sickness, clinical trial beginning this month
...ration is important for treating the disease which occurs in villages where it can devastate afflicted popul...eating late stage African sleeping sickness, which occurs when the parasite over time enters the brain." The new drug candidates are active because they can ...Researchers track down cause of a disfiguring bone disorder
... density, or osteosclerosis. The effect primarily occurs in the skull and lower jaw of Van Buchem patients, causing facial distortions and pinching cranial nerves, which can lead to deafness and blindness. Collarbones, ribs and long bones can also be affected. The research team, led by Gabriela Loots of L...Thinking the pain away? Study shows the brain's painkillers may cause 'placebo effect'
...rch will be needed to determine whether the effect occurs in women and in people with various illnesses. The power of placebos to ease pain symptoms has been well-documented in many groups of subjects and illnesses, but the researchers started with healthy young males to rule out the impact of chronic pain,...Scientists focus on 'dwarf eye'
...eptors, the eye's light-detecting cells. Blindness occurs when these cells die after detachment of the retina from the RPE. Beneath the RPE are two layers of structural tissue that give the eye its shape. During childhood, these tissues stretch, like a balloon, as the eye grows. "The RPE is believed to be...A molecule impedes the destruction of the 'Brucella' bacteria
...ellular products necessary to destroy bacteria) as occurs in other micro-organisms. On the contrary, they reach certain compartments within the macrophage. Here the bacteria multiply and establish a chain of events that determine the illness. Brucellosis, the illness caused by these bacteria, is of great i...Carnegie Mellon University research reveals how cells process large genes
...imilar analyses suggest that the same process also occurs in large introns of mammals, including humans, and the Lopez team is now testing this hypothesis experimentally. "The striking evolutionary conservation of ratchetting points suggests that recursive splicing provides specific advantages for large in...Scientists show that tick-borne flaviviruses use a novel mechanism to evade host defenses
...t definitive study that dissects where the failure occurs in the signaling pathway, and then identifies some of the interacting partners in the cell and virus." Prior to this work, Dr. Bloom says, scientists knew only that NS5 helped tick-borne flaviviruses replicate. RML's Sonja Best, Ph.D., who spearhead...Reversal of role for a viral protein associated with the development of lymphoma
...imilar analyses suggest that the same process also occurs in large introns of mammals, including humans, and the Lopez team is now testing this hypothesis experimentally. "The striking evolutionary conservation of ratchetting points suggests that recursive splicing provides specific advantages for large in...