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Tag: "obstacles" at biology news

W.M. Keck Foundation funds study of friendly microbes

...unding high-risk projects designed to overcome key obstacles in emerging fields in science so that rapid progress can subsequently be made," Gordon says. "Their support of our studies of the genomic and metabolic foundations of mutually beneficial (symbiotic) relationships between microbes and humans will allo...

Found: Missing sequence of the human Y chromosome

...n genome, were considered to be one of the biggest obstacles tofinishing the human genome sequence. "The identification of thesesegmental duplications suggests an underrepresentation ofpericentromeric regions of the acrocentric chromosomes in the currenthuman genome sequence," Rappold pointed out.The current s...

Muscle-targeted gene therapy reverses rare muscular dystrophy in mice

...against introduced enzyme, which currently present obstacles to enzyme replacement therapy and liver-targeted gene therapy in Pompe disease," Koeberl said. Clinical trials of either the muscle- or liver-targeted gene therapies will likely take several years to launch, Koeberl said. Collaborators on the gene ...

New component of the 'brakes' on nerve regeneration found

Among the principal obstacles to regenerating spinal cord and brain cells after injury is the "braking" machinery in neurons that prevents regeneration. While peripheral nerves have no such machinery and can readily regenerate, central nervous system (CNS) neurons have their brak...

Researchers discover mechanism for multiplying adult stem cells

... could not produce mature tissue. One of the main obstacles with adult stem cell research is that, in order for these cells to be therapeutically useful, researchers need to multiply them in the lab. But when adult stem cells are isolated, they immediately start growing into their designated tissue type. It w...

Gap-climbing fruit flies reveal components of goal-driven behaviors

Like humans, other animals are faced with everyday obstacles in their physical environments and must engage app...d motor skills to deal with them. Navigating these obstacles can involve highly complex events in mammals and other vertebrates, but in new work, researchers hav...

Hopkins scientists uncover 'tags' that force proteins to cell surface

...orce proteins to the cell surface, we can overcome obstacles that have prevented laboratory study of some really important proteins," says Li. The application of these surface tags to force protein transportation to the cell surface is the subject of a Patent Cooperation Treaty (PCT) patent application submitt...

Newfound roadblock to interferon effectiveness against malignant melanoma

... a resistance to the drug, posing one of the major obstacles in the clinical treatment of this cancer. Now Professor Manfred Schartl and Dr. Claudia Wellbrock, scientists at the University of W�rzburg, believe they have an explanation for how this interferon resistance is acquired. They have found that when a...

Clearing jams in copy machinery

... fidelity Pol IV, coordinate their action to cross obstacles encountered in the replication process. They attach themselves at the same time to one beta sliding clamp. Pol III copies the original DNA, and acts as a proofreader to catch any misspellings and cuts any base that is wrong. But Pol III is a perfecti...

Delaware scientists make significant advance in study of small RNAs

...e Delaware Biotechnology Institute, overcame these obstacles to make a breakthrough in the study of small RNAs from Arabidopsis. Prior to their work, scientists worldwide in a painstakingly slow and labor-intensive process had documented about 6,000 small RNAs from the plant. Meyers had been sequencing RNAs...

Report focuses on challenges to unlocking future promise of vaccines

...e report also provides recommendations to overcome obstacles that prevent the best use of existing vaccines. "Vaccines are available for some diseases that continue to plague humans, but not for others. Even when a licensed vaccine is available for a given disease, numerous barriers can block its use, includ...

Salk researchers make fast strides towards understanding how our body controls walking

...at coordinates walking movements - one of the main obstacles in developing new treatments for spinal cord injuries. "Knowing which circuits are important and understanding how they control the essential aspects of walking should put us in a better position to design treatments or implants that restore or acti...

How low can you go? Ants learn to limbo

...f their habitat. Climbing over or crawling beneath obstacles means that ants do not have to make large detours to go around them. "We found that the ants visually assessed the height of the barrier and learned how to lower their body enough to crawl under without stopping", explains Tobias Seidl, "When the b...

Progress being made in exploring potential use of stem cells to treat heart disease

...ental Cardiology. "Although there are clearly many obstacles to overcome, it is significant that a roadmap of the derivation and use of stem cells for human heart disease is now conceivable." In the Nature article, Srivastava and Ivey point to several challenges ahead: Developing the ability not only to gui...

PTEN: the Treg's handbrake

...earchers with a way to overcome one of the biggest obstacles to harnessing their therapeutic potential. ...

Experimental RNA-based drug kills prostate cancer cells effectively and safely

...nd it shows it is possible to overcome many of the obstacles that have hampered the development of RNA-based dr...ental surgery. Scientists have encountered major obstacles when trying to deliver silencing RNAs to tumors, Giangrande said. Previous RNA-based drugs have been...

Discovery of agile molecular motors could aid in treating motor neuron diseases

... surprisingly flexible and agile, able to navigate obstacles within the cell. These observations could lead to better ways to treat motor neuron diseases. Motor neuron diseases are a group of progressive neurological disorders that destroy motor neurons, the cells that control voluntary muscles for such activ...

Stimulation of the semicircular canals can artificially control human walking and balance

...e enough to keep subjects on pathways and avoiding obstacles while walking blindfolded through botanical gardens. The researchers also found that with a subject's head in another position, exactly the same stimulus could be used to disturb upright balance, causing the subject to lean in one direction or the ot...

3-D model reveals secrets of metastasis

... of Sciences. "Two-dimensional assays ignore the obstacles that cells face in their natural contexts," explains Zaman, who recently became an assistant professor at the University of Texas at Austin. "In 3D, cells move through a thick jungle of fibers, or "vines" TM , that hinder forward progress." Cells m...

NYU researchers decorate virus particles, showing potential to enhance MRI capabilities

...sue types." While Kirshenbaum cautioned that many obstacles remain in using this process to enhance MRI for clinical applications, he said the results point to the potential of enhancing specific MRI capabilities. "If a radiologist wants to design a versatile probe that can be used in a variety of diff...

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