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Tag: "nuclear" at biology news

Secret of smallpox's success may lead to bioterror cure

...cans against chemical, biological, radiological or nuclear attack. The idea for the vaccine comes from Jacobs and his team's discovery of a gene that gives pox viruses uncanny ability to camouflage themselves from mammalian immune systems. The ability to stay hidden allows the smallpox virus, in particular,...

Cellular Defects in Premature Aging Disease are Reversible

...rinkled and misshapen. In addition, numerous other nuclear proteins show reduced expression. "Our NCI team a...tural ellipsoid shape, and the expression of other nuclear proteins was also restored to normal levels. "It's amazing that we could take a cell that looked ab...

Scientists generate patient-specific stem cells, Science study says

...stem cell lines specifically tailored to match the nuclear DNA of patients, both males and females of various...ic stem cell lines was created by transferring the nuclear genetic material from a non-reproductive cell of a patient into a donated egg, or "oocyte," whose nu...

SuperLigands - a database of ligand structures derived from the Protein Data Bank

...stem cell lines specifically tailored to match the nuclear DNA of patients, both males and females of various...ic stem cell lines was created by transferring the nuclear genetic material from a non-reproductive cell of a patient into a donated egg, or "oocyte," whose nu...

Researchers reveal secret of key protein in brain and heart function

...s to NMDA receptors. The team used high-resolution nuclear magnetic resonance spectroscopy to solve the structure of PDZ1, as well as a small portion of the receptor to which it binds. Mierke said the group is now developing a molecule that can inhibit PDZ1 as well as PDZ2, the first boxcar on the multi-dom...

By creating molecular bridge, scientists change function of a protein

...e function of the human estrogen receptor alpha, a nuclear hormone receptor mostly expressed in the prostate, ovary and urinary tract. What they did was modify the estrogen receptor in a step-wise fashion, Zhao said. They used testosterone and progesterone to build the bridge. The receptor was gradually alt...

Researchers extend mouse lifespan by protecting against free radicals

...itochondria also had fewer mutations, and the MCAT nuclear DNA had fewer oxidized components. "This study is very supportive of the free-radical theory of aging," said Rabinovitch. "It shows the significance of free radicals, and of reactive oxygen species in particular, in the aging process." This study a...

Researchers discover mechanism for multiplying adult stem cells

...e cells to be reprogrammed when used as donors for nuclear transplantation. If so, it may help scientists more efficiently "customize" embryonic stem cells that could be used to treat diseases such as diabetes or Parkinson's. ...

Scientists succeed in cloning human embryos from eggs matured in the lab

... MII oocytes. From each of these, they removed the nuclear apparatus, which contained the chromosomes that he... another person ?a process known as non-autologous nuclear transfer. After time for nuclear re-programming the oocytes were artificially activated by incubatio...

Invitrogen Launches i-Path -- A Unique Systems Biology Platform at BIO 2005

... MII oocytes. From each of these, they removed the nuclear apparatus, which contained the chromosomes that he... another person ?a process known as non-autologous nuclear transfer. After time for nuclear re-programming the oocytes were artificially activated by incubatio...

Anthrax inhibitors identified by Burnham team

...ch based on assays conducted with highly sensitive nuclear magnetic resonance ("NMR") techniques developed in Dr. Pellecchia's laboratory, the scientists were able to identify a scaffold that served as a template for designing a preferred structure for small-molecule inhibitors of LF. Lead compounds were syn...

Human embryonic stem cells have the potential to develop into eggs and sperm in the laboratory

...ould also be used for therapeutic cloning (somatic nuclear replacement) circumventing the need for eggs from patients who donate them, as this is a major limitation of this technique at the moment. We would then have completed the circle of making HESCs from eggs that came from HESCs ?what came first the chi...

Study shows how retinoic acid enters a cell's nucleus

...cids are organized in a certain sequence, called a nuclear localization signal (NLS). However, CRABP-II does not have a recognizable NLS. Researchers have long wondered how proteins without an NLS enter a cell's nucleus. By comparing the 3-D structures of the CRABP-II protein before and after it comes in co...

Sandia completes depleted uranium study

...t of the process used to enrich uranium for use in nuclear reactors and nuclear weapons. During the enrichment process, the fraction of one type of uranium (uranium-235) is increas...

Researchers devise new technique for creating human stem cells

...proach could become an alternative to somatic cell nuclear transfer (SCNT), a method that is currently used t...e an embryonic stem cell from a somatic cell is by nuclear transfer into oocytes. Taking advantage of this current capability -- such as colleagues in South Ko...

MSU researchers receive $4 million grant to uncover gene functions

...ists will determine the functions of roughly 4,400 nuclear genes from the Arabidopsis plant. Arabidopsis is a flowering plant whose entire 29,000 gene sequence is known. Scientists will focus on the genes which encode the chloroplast-targeted proteins that trigger photosynthesis. Understanding how these ge...

Physical and functional interaction of key cell growth molecules linked to cancer

...lignant biology of tumor cells with high levels of nuclear EGFR and STAT3." This research may open new avenues for designing anticancer therapies against EGFR, STAT3, and iNOS/NO. ...

MERIS monitoring tracks planetary photosynthesis levels

...ve on vegetation growth. Forget fossil fuels and nuclear plants: on a global scale solar power is the dominant source of energy. Across land and sea, our world's plant life uses the process called photosynthesis to convert incoming sunlight into chemical energy, along the way producing all the oxygen we br...

AACR Favors 'full spectrum of stem cell research biology'

...position supports the "ethical use of somatic cell nuclear transfer," noting that the technique, "promises to reveal the role of specific genetic alterations in tumorigenesis and further refine evaluations of drug activity, as well as generate immune-compatible material for transplant therapies." The primar...

Unweaving amyloid fibers to solve prion puzzles

... image proteins, such as X-ray crystallography and nuclear magnetic resonance imaging, don't work with fibrous structures such as amyloids. And scientists depend on these high resolution images of molecules in order to study their function. Now, researchers have found a way to work around these limitations,...

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