Novel antigen-cloning technique may boost efforts to develop a melanoma vaccine
...ge percentage of patients," Herlyn says. Herlyn notes that the new antigen-cloning technique developed for this study is a major advance over the cumbersome method previously required to accomplish the task, and she anticipates that experimental vaccine developers will find it of significant value in th...Yale biologists 'trick' viruses into extinction
...y might be used against human viruses like HIV. He notes that HIV recognizes the T-cells it infects by CD4 molecules on the cell surface, but it then requires functions of the cell nucleus to reproduce. Current anti-HIV therapies are designed to maintain high T-cell counts in the human body, so that the im...Does God answer prayer? ASU research says 'yes'
...rapeutic intervention is controversial. Yet, Hodge notes that survey research indicates that many people use intercessory prayer as an intervention to aid healing, which raises questions about its effectiveness as an intervention strategy. “Overall, the meta-analysis indicates that prayer is effective. ...Scripps research team discovers a chemical pathway that causes mice to overeat and gain weight
...ex phenomenon to explore," says Sanchez-Alavez. He notes that the next step in the research will be to determine whether the obese phenotype observed in the EP3 receptor deficient mice is dependent on the lack of EP3 in the central nervous system and/or peripheral organs, as EP3 is expressed in both locati...Exploring the molecular origin of blood clot flexibility
...r André Brown, a physics graduate student at Penn, notes that this research is a first step towards underst...he stress induced by the atomic force microscope," notes Brown. Once the origins of the mechanical properties of clots are well understood, it may be poss...White blood cells in lung produce histamine seen in allergies
...s, which are classically associated with allergy," notes Caughey, who is also a professor of medicine at the University of California, San Francisco. Caughey says the result could mean that histamine acts as a link between airway infections and asthma and bronchitis, which are associated with allergy. "I...Intravenous nanoparticle gene therapy shows activity in stage IV lung cancer
...al time for all patients is 14.6 months, which Lu notes compares favorably to a seven-month median survival time for patients receiving second line therapy. All patients on the trial had been treated with front line cisplatin combination chemotherapy, which failed to halt their disease. The clinical ...Cancer researchers add spice to research against rare neuromuscular disease
...ome with radiation treatments for cancer. Chang notes that ginger, a family of spices that includes curc...the promise it offers for Kennedy's disease, Chang notes that ASC-J9 must be rigorously screened for side effects and effectiveness, through clinical studies...Protein found to shield pancreatic cancer cells from self-destruction
... of experimental therapeutics and study co-author, notes that the research also shows that the self-consuming cell death prevented by TG2 is independent of a prominent molecular pathway also known to regulate autophagy called the mammalian target of rapamycin. "Targeting TG2, or its activating protein P...Scientists unlock mystery of embryonic stem cell signaling pathway
... Japan) using mouse embryonic stem cells, but Kahn notes that subsequent pilot studies using human embryonic stem cells, in collaboration with Dr. Qilong Ying at the Center for Stem Cell and Regenerative Medicine at the Keck School of Medicine, have confirmed that IQ-1 plays a similar role in that system a...NIH announces phase III clinical trial of creatine for Parkinson's disease
...usually hasn't been included in clinical studies," notes Dr. Kieburtz. The study is designed to include a broad range of people, with special efforts to recruit a diverse population that is similar to the makeup of the population with PD in the United States. The investigators will measure disease prog......y processing, as seen in schizophrenia." Kayser notes that the findings also could be used to reveal the role of audio-visual integration in communication or to help pin down where sounds are coming from. "Clearly, our acoustical understanding often improves if we can see the lips of the speaker—for exa...Protein may hold key to decreasing organ dysfunction rates in heart transplants
...this injury concomitant to organ transplantation," notes Aigner, stressing the value of this research to the development of new treatment options in organ transplantation. ...New insights into autoimmunity and depression
...s another intriguing aspect of the present study," notes its leading author, Yehuda Shoenfeld, M.D., while emphasizing the need for further investigation through large-scale clinical studies. "Elucidating the mechanisms by which anti-ribosomal P induces behavioral changes may lead to novel therapeutic adv...ASU researchers test antibacterial effects of healing clays
...no effect. Williams reviewed the mother's work and notes that "Line Brunet de Courssou was a careful observer." However, Madame Brunet de Courssou was not a scientist. The mother, who is now deceased, approached the WHO in 2002 at its fifth advisory group meeting on Buruli ulcer, having documented more tha...End-of-life care can be improved
...o improve end-of-life care in the ICU. Dr. Levy notes that this supplement documents a need for additional research and quality improvement in order to realize the potential for improving the care delivered to critically ill patients at the end of life as well as the care provided to their families. ...Signal protein shows promise for blocking tumor promoters in skin cells
... molecule Srcasm are typically low in tumor cells, notes senior author John Seykora, MD, PhD, Assistant Professor of Dermatology. The current findings show that Srcasm can reduce the amount of Src kinases in cells; they have also shown that increased activity of these kinases is associated with cancerous s...Einstein researchers demonstrate a novel approach to treating AIDS
... Dr. Goldstein, also a senior author of the study, notes that radioimmunotherapy might be particularly useful for people newly exposed to HIV, such as healthcare workers with needlestick injuries. "Studies show that giving highly active antiretroviral therapy (HAART) to people within 24 hours of exposure t...Cities change the songs of birds
... low-frequency noise used fewer low-frequency song notes compared to nearby individuals in quieter territories. That single-population study, in Leiden, The Netherlands, included only urban birds, but territory conditions ranged from very quiet to very noisy. The earlier study predicted the possibility tha......mutations in an exchange factor in human disease," notes Neel, explaining that for families at risk for Noonan syndrome, the findings will aid in prenatal diagnosis and genetic counseling for the disorder. "Furthermore," Neel adds, "because the other two genes that cause Noonan syndrome are also mutated...