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Tag: "notch" at biology news

Chemical switch triggers critical cell activities

...ike the paddle wheel on a riverboat that carries a notch on one of its paddles. As the docking site rotates, it carries the notch all the way around to the other side, next to NEDD8. As soon as the notch of the docking site is ne...

Master regulatory gene found that guides fate of blood-producing stem cells

...t in regulating HSC fate-for example homebox, wnt, notch 1, and telomerase genes. Emerson and colleagues figured that one transcription factor, called NF-Y, was required for activating promoters of all of these genes. What's more, they found that fully assembled NF-Y was activated in stem cells and disappe...

New lead reported in tumor angiogenesis

...s called notch. Other laboratories have shown that notch plays a key role during human development in formi...d vessels. Oddly, Wang noted, the possible role of notch in tumor angiogenesis has not been well studied. After further laboratory and mouse experiments, Wa...

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