St. Jude study shows genes play an unexpected role in their own activation
...sphate-tagged CREB binding to CBP/p300 at KIX does not account for most gene activation controlled by the...dent mechanism; and that each mechanism may or may not contribute equally to activating a specific gene. The team also found evidence that other proteins c...Experimental gene therapy 'abolishes' arthritis pain and lessens joint damage
...n 18 months, Kyrkanides said. Early results, while not yet published, suggest that one serotype of the AA...as contributed to the emerging theory that pain is not a symptom of osteoarthritis, but is instead part of the disease. According to this new paradigm, pai...Genome of Clostridium botulinum reveals the background to world's deadliest toxin
...casing of insects and small crustaceans. It is not only animals that can feel the wrath of C. botulinum, explains Dr Sebaihia: "The soil can be a harsh environment and food can be scarce. To see off the competition, C. botulinum comes with its own ‘antibiotic’ — a chemical called boticin that kills c...Ants show us how to make super-highways
...he pothole pluggers more than compensates for them not carrying prey themselves. This study provides rare quantitative evidence from animal societies that extreme specialisation by a minority can significantly improve the performance of a majority to benefit the group as a whole. It also suggests that...'Virtual autopsy' helps identify drowning as cause of death
... support the diagnosis of drowning include but are not limited to frothy fluid in the airways or lungs, h.... In cases of suspicious death, the procedure does not damage or destroy key forensic evidence, as can happen during a conventional autopsy. In addition, M...Treating HIV in war zones -- Public health emergencies need rapid advice from WHO
... conflict, and humanitarian health agencies should not wait until a conflict is over before launching HIV...ive care Educating patients on the importance of not conserving their pills and trying to take them on time even during periods of instability. Cu...Researchers use MRI to predict recovery after spinal cord injury
...logically intact upon admission. One patient could not be classified. The majority of the patients had been injured in motor vehicle accidents. MRI exams were obtained within 24 to 48 hours of injury. The research team studied three measurable imaging parameters: maximum spinal cord compression (MSCC)...Avian influenza survivors' antibodies effective at neutralising H5N1 strain
... was found to have spread from the lungs; this was not the case in those who survived. "We have shown ... people who have become infected with the virus do not tend to report to their local healthcare facilities until several days after the onset of illness." ...Eavesdropping comes naturally to young song sparrows
...tallizes at around 10 to 11 months of age and does not change. Beecher and his colleagues earlier prop...re critical in song learning. However, they could not determine if the young birds learned more by direct interaction with a tutor or by eavesdropping. ...New research shows sharks use their noses and bodies to locate smells
...om Boston University marine biologists, sharks can not use just their noses to locate prey; they also nee...ith the small hairs on the face. Until now, it had not been demonstrated that the lateral line also aids in the tracking of odor plumes. "Odor plumes are...First confirmed common genetic risk factors for breast cancer
...ucial to biological activities that previously had not been implicated as triggers of breast cancer. The genes carry the DNA recipes for proteins important to the growth and duplication of body cells and the signalling, or communications, that must occur between cells in order for the body to function n...Cytomegalovirus exacerbates atherosclerosis through an autoimmune mechanism
... artery disease, are able to induce the activation not only of genes involved in apoptosis but also of many other genes that encode for proteins involved in different aspects of the atherosclerotic process (lipid metabolism, inflammation, adhesion molecules, etc.). For the first time, the study shows tha...New designer lipid-like peptide with lipid nanostructures for drug delivery systems
...ine, open-access journal PLoS ONE. Their findings not only help us to understand the basic science of how lipid-like peptides interact with lipid molecules, but also may provide new strategies for the encapsulation and the delivery of biological active materials. They detailed their findings in the rep...Common treatment for methamphetamine overdose may damage brain cells
...nd methamphetamine causes the destructive effects, not either one alone. Senior author Bryan Yamamoto, Ph...rlezon, PhD, at Harvard's McLean Hospital, who was not affiliated with the study. "A crucial next step is to determine how atypical antipsychotic medicatio...Want to save polar bears? Follow the ice
... to save the Earth’s largest terrestrial predator, not by following the bears themselves, but the receding sea ice habitat that may drastically shrink as a result of global warming. In a project named "Warm Waters for Cool Bears," WCS will use both current and historical satellite imagery to predict wher...For many insects, winter survival is in the genes
...ons of each heat-shock protein. "We assume it's not simply redundancy in the system, but that each protein makes a unique contribution somehow," Denlinger said. "This protective mechanism is much more complex than we envisioned." ...Mule deer moms rescue other fawns
... their own species' call, and only when they could not see their own fawn. "The fact that mule deer r...nding next to them safe and sound revealed they do not help other fawns because they mistake them for their own," said lead author Susan Lingle, who conduc...Detecting cold, feeling pain: Study reveals why menthol feels fresh
...uding menthol. The genetically engineered mice did not discriminate between warm and cold surfaces until ...tion to rest. As the mice lacking the gene were not completely insensitive to cold -- they avoided contact with surfaces below 10 degrees C, though with...'Virtual Patient' to simulate real-time organ motions for radiation therapy
...d tissues in the human body. "Live patients are not static beings, and a moving organ such as the lung...Xu said. The fourth dimension of the VIP-Man is not easily achieved, according to Xu. Currently Xu and De are focusing their energy on respiratory funct...NASA-funded robotic sub finds bottom of world's deepest sinkhole
...ealed that the geothermal sinkhole, or cenote, did not have a tunnel or any other obvious underwater connections with neighboring cenotes in the Mexican state of Tamaulipas. It also obtained numerous samples of water and the gooey biofilm coating the cenote’s walls. "We’re very pleased about the perfo...