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Tag: "normal" at biology news

Reactivated gene shrinks tumors

...ncer Research and first author of the paper. In normal cells, p53 controls the cell cycle. In other words...led that turning on p53 has no damaging effects in normal cells. The researchers had worried that p53 would kill normal cells because it had never been expres...

Anti-dandruff compound may help fight epilepsy

...flow through, raising the possibility of restoring normal nerve cell activity. “Most drug discoveries uncover chemicals that stop things from working - it’s a lot easier to close or block a door than open it,?Li says. “But here we found a chemical that makes a defective protein work better. So now we ha...

Turning a cellular sentinel into a cancer killer

...gues found no evidence that restoring p53 affected normal cells. "That gives us a broader therapeutic window...nd rapidly by one of these two mechanisms, whereas normal cells seem to tolerate reactivation of p53 quite well," he said. In the December 29, 2006, issue o...

Light-based probe 'sees' early cancers in first tests on human tissue

...re-cancer in the esophagus and distinguish it from normal tissue like you would find in the stomach." The fa/LCI device detects irregularities in the nucleus, or central component, of cells, through changes in the way laser light scatters. "The size and shape of cell nuclei are powerful indicators of thi...

The influence of the menstrual cycle on the female brain

...ifferent types of reward (food, money, drugs?. The normal functioning of this system plays a fundamental rol...ly in cases of Parkinson's disease, schizophrenia, normal ageing and drug and gambling addictions. ...

MIT: Pulsing light silences overactive neurons

...rs a way to study other brain diseases, as well as normal brain circuitry, offering insight into which brain regions and neurons contribute to specific behaviors or pathological states, Boyden said. The halorhodopsin gene was originally discovered in the 1980s, but Boyden didn't think its full potential ...

Cancer scientists create 'human' leukemia process to map how disease begins, progresses

...Institute (OCI) have developed a method to convert normal human blood cells into "human" leukemia stem cell...stin Hope introduced a specific leukemia gene into normal human stem cells and injected the genetically altered cells into mice that lacked immune systems. Th...

Creating new life forms that may help eradicate cancer affecting women

...ller (cytotoxic T) cells to elicit a stronger than normal immune response to the presence of cancer cells. The vaccines "teach" the immune system to mount a specialized, targeted response that is lethal to cancer. When Listeria is introduced in the body, it has a powerful, direct stimulatory effect on ...

Nanoparticles for delivery of prostate cancer treatment

...d tumors, thus destroying the tumors while leaving normal tissue unharmed. The technology uses a synthet...nner surface of blood vessels in tumors but not in normal tissues. The Icon binds to TF more strongly and specifically than a natural antibody. Because the Ic...

Minuscule molecules pack a powerful punch

...system in the knockout mice do not work as well as normal cells and the mice develop symptoms similar to tho...hough knockout of miR-155 did not appear to affect normal growth and development of cells in the immune system, each major cell type - T-cells, B-cells and de...

Drug treatment improves learning in mice with Down syndrome symptoms, Stanford/Packard study shows

...ofessor Rob Malenka, PhD, found that it approached normal levels after chronic PTZ treatment and remained co...tment did not improve the learning capabilities of normal mice. "We’re not in the business of cognitive enhancement," said Fernandez. "Basically, we have s...

New insights into autoimmunity and depression

...purposes, equal numbers of mice were injected with normal human immunoglobin G. All the mice were then subjected to a series of tests: a forced swimming test in a glass beaker partially filled water to evaluate escape-oriented behaviors, such as rearing and jumping; rotarod and grip strength tests to gauge...

Brain tissue reveals possible genetic trigger for schizophrenia

...s between neurons come and go all the time. It's a normal process for them to be pruned and grow again, depending on what the brain needs to do to interact with the environment," Perkins explained. "There is growing evidence that schizophrenia may related to disordered synaptic plasticity," she added. "...

Reversing cancer cells to normal cells

...discovered that aggressive melanoma cells (but not normal skin cells nor less aggressive melanoma cells) con...ed to the reversal of the melanoma cells to a more normal cell type. This is a promising area of research, says Dr. Hendrix. The discovery of a new signal...

When smell cells fail they call in stem cell reserves

...a class of active-duty stem cells that help repair normal wear and tear. They don’t come in until things are really bad.? The only nerve cells in the body to run directly from the brain to the outside world, olfactory cells are under constant assault from harsh chemicals that one might happen to catch a ...

Major link in brain-obesity puzzle found

...ge. For the new paper, they looked at not only normal mice and mice that didn’t have the SH2B1 gene, but...ice that made SH2B1 only in brain cells, either in normal or larger-than-normal amounts. They found that restoring SH2B1 just in the brain completely correcte...

New research shows why too much memory may be a bad thing

...a good thing, and that forgetting is important for normal cognition and behavior," said Gaël Malleret, Ph.D., a research scientist at the Center for Neurobiology and Behavior at Columbia University Medical Center and the paper’s co-first author. "Altogether, our findings suggest that new neurons in the hipp...

'Exercise pill' switches on gene that tells cells to burn fat

...to weight gain and twice the physical endurance of normal mice. Because they were able to run an hour longer than a normal mouse, they were dubbed "marathon mice." Subsequent work in the Evans laboratory found that act...

Chromosomal microarray analysis proves accurate

...said, there are many areas of the genome where all normal people have gains or losses of genetic material co...at of the parents can often determine if this is a normal familial variation or a disease-causing one....

Cancer cells forming blood vessels send their copper to the edge

...e copper in the body without disrupting the body's normal functions can inhibit the growth of blood vessels ?and some of these compounds are even in clinical trials for use in cancer therapy. Yet, the biological basis for this sensitivity of angiogenesis to copper has been an enigma. In search of an answ...

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