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Tag: "normal" at biology news

Severe mental retardation gene mutation identified

... identified genes are involved in the formation of normal intellectual processing as well," concludes Dr. Raymond. Now that a posttranslational modification enzyme has been found to be mutated in X-linked mental retardation, the researchers expect to find similar genes related to other mental retardatio...

Knocking out survival protein could aid leukemia treatment

...ival protein is called Mcl1. It usually helps keep normal cells healthy and is involved in the development of the components of the immune system, but it can also help prolong survival of cancer cells. Cells with an overabundance of the protein are also more resistant to anticancer drugs such as rituxim...

Stanford scientists make major breakthrough in regenerative medicine

...e an abnormal organ or tissue back to its vibrant, normal state," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. "This study is a landmark in regenerative medicine; the Stanford group has accomplished the biological equivalent of turning a sow’s ear into a silk purse and back again." ...

Protein key to organ growth

...u reduce the levels of TCTP, tumor cells revert to normal in the laboratory," said Choi. However, in their studies of fruit flies, Choi and his colleagues found when the protein is lacking, it has a profound effect on flies. However, too much does not cause tumor growth. Choi is also a faculty member of the...

Gene hunters close in on Lou Gehrig’s disease

... ALS patients were more likely to have compared to normal individuals without the disease. “This is the first major step toward understanding how genetics may influence the most common form of ALS,?says co-researcher Jeffrey D. Rothstein, M.D., Ph.D., professor in the Department of Neurology at Johns Hop...

Walking molecule now carries packages

... rather than hopping around in all directions as a normal molecule would do. Now it can carry a load." Bartels said the continuing evolutionary process will take some time. "Ten years ago, a cell phone could just place calls, nothing else. Now it plays mp3-files, organizes your day, lets you send email...

Ultrasound upgrade produces images that work like 3-D movies

...ject from slightly different angles, mimicking the normal difference between left and right eye views. Special glasses or goggles can then be used to fuse the two images into one, gaining a 3-D effect. This principle lies behind 3-D movies and the familiar Fisher Price View-Master toy. With practice, som...

Leukemic cells find safe haven in bone marrow

...g cells), and form the nurturing environment where normal blood cells and leukemic cells grow. "Leukemic cells that resist asparaginase and survive in this protective niche of the bone marrow might be the reason that leukemia recurs in some children who have been treated with this drug," said Dario Cam...

Salamanders suffer delayed effects of common herbicide

...srupt the production of hormones that are vital to normal bodily functions. Concentrations of atrazine as low as 0.1 parts per billion have been shown to cause male frogs to develop both male and female organs by altering their production of sex hormones. Findings from Rohr's study, which was funded by t...

MicroRNA helps prevent tumors

...sing genes, colonies of mouse cells that expressed normal or shortened Hmga2 did not grow significantly, while cells in which Hmga2 contained disrupted let-7 sites did. In fact, the more that let-7 sites were damaged, the greater the number of colonies. Mayr also worked with MIT assistant professor Mich...

Viral protein is an effective preventative against infection

...ll a specific type of bacteria, leaving the body’s normal flora untouched. "We knew from our previous experiments that if you treat an animal infected or colonized with pneumococci or streptococci with these lysins, you could cure or decolonize them," says Fischetti. "But I was looking for a way to see i...

Targeting tumors the natural way

...els of certain receptors on their surfaces than do normal cells, a fact that allows scientists to pinpoint t...ficantly higher numbers on cancerous cells than on normal ones." ...

MicroRNAs can be tumor suppressors

... with human tumors, the researchers found that, in normal cells, a microRNA called let-7 binds to the 3?end of the HMGA2 mRNA transcript and suppresses its expression in the cell cytosol. However, chromosomal breaks that shorten the 3?end of the HMGA2 transcript,and prevent let-7 binding, result in aberrant...

Research to spotlight carbon monoxide benefits

...We don't want to administer carbon monoxide in its normal toxic gaseous form; rather we want to develop molecules that will release it in a sort of slow trickle feed. We aim to make tuneable compounds which allow you to alter the rate at which carbon monoxide is released, which could be important in differe...

Linheng Li Lab documents the development of cancer stem cells

...pectively, on a new publication that clarifies how normal stem cells become cancer stem cells and how cancer...s; that they are slow cycling but more active than normal stem cells; and that cancer stem cells and stromal insertions initiate the process of primary tumori...

Army research mission focused on autism

"I had a perfectly normal baby. He hit all his developmental landmarks but after his first birthday he seemed to be sick all of the time, with infection after infection. He stopped eating and was no longer happy and playful. By 17 months he had stopped talking, interacting, o...

Killing the messenger RNA -- But which one?

... transgenic mice unable to perform RNA editing and normal control mice, the researchers found that a complet...production of the PRPS1 enzyme to about double its normal levels. This, in turn, drove levels of uric acid up to about two times what they should be. "This...

Reminding doctors which antibiotics to prescribe cuts C. difficile infection rates

...eir action against many types of bacteria---damage normal intestinal flora in addition to killing disease-ca...et only specific types of bug cause less damage to normal gut bacteria and therefore reduce the likelihood that CD will take hold. In their audit study, ...

Engineering the heart piece by piece

...le to engineer heart muscle that closely resembles normal heart muscle physiology without any synthetic scaffolding material. The U-M team and others have also shown how polymeric scaffolds can be used to engineer heart muscle of any shape or size to match the area of the damaged heart muscle ?raising the p...

Blocking immune cell action increases Alzheimer's-associated protein deposits

...mice with two copies of CCR2 and only 1 percent of normal mice. Analysis of levels of several enzymes known to either promote or break down amyloid-beta deposits revealed that a lack of CCR2 appears to reduce clearance of the toxic protein from the brain. Other tests suggest that CCR2 is required for m...

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