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Tag: "normal" at biology news

Researchers urge monitoring of bone health during chemotherapy

...oclasts, which resorb bone material as part of the normal process of bone turnover. The resulting loss of bone density created a favorable environment for bone tumor growth. When the researchers injected melanoma or breast cancer cells into mice, those getting G-CSF developed a two-fold increase in tumor...

Cancer tip -- Nanoparticles can damage DNA, increase cancer risk

... large enough to cause trouble by interfering with normal cell processes, researchers at the University of Massachusetts say. Such nanoparticles are currently in use in electronics, cosmetics, and chemical manufacturing, among others industries. Because of their extremely small size, they can be difficult ...

Selective marker found to indicate aggressive form of breast cancer

...t and relapse. It is more commonly detected during normal screening mammogram intervals than other screening subtypes, which likely reflects its aggressive nature. These important clinical correlations likely explain why this subtype disproportionately accounts for breast cancer mortality, according to DiR...

Erectile dysfunction in diabetes is due to selective defect in the brain

...lays an important role in the neurotransmission of normal penile erection. Penile erection is a behavior...of L-NMMA on NMDA mediated behavioral responses in normal rats; experiment two measured behavioral responses to NMDA or sodium nitroprusside (SNP), an NO dono...

Gene therapy for blindness clears hurdle in mice

...as injected below the retinas in more than a dozen normal mice. Analysis showed the technique reduced the am... Gorbatyuk said. "The second step, introducing the normal gene to the retina, will show whether we are able to restore vision in this model or not." If bot...

Dual gene therapy suppresses lung cancer in preclinical test

...s after treatment while leaving a control group of normal cells unaffected. The cancer cell lines treated wi... Roth says. "These genes don't have much effect on normal tissue or normal cells when they are overexpressed. It's really just cancer cells where they seem to...

Notorious cancer gene may work by destroying messenger

...e significantly higher in cancer cells compared to normal cells. Earlier research led by Schoenberg found that PMR1 helps control protein production by destroying particular messenger RNAs (mRNAs), molecules that carry the information used to assemble a protein. That work showed that PMR1 attaches t...

Scientists map key landmarks in human genome

...ing melanoma and breast cancer, as well as several normal human cell types. A critical component of the analysis involved processing the data using computational algorithms devised by Dana-Farber faculty member X. Shirley Liu, PhD, and her postdoctoral fellow Jun S. Song, PhD, working closely with Fisher's ...

Molecular signature may identify cisplatin-sensitive breast tumors

...he function of p63, a protein that plays a role in normal breast development and is related to the common tu...sue samples from triple-negative breast tumors and normal breast tissues for the expression of several forms of p63 and another related protein called p73, kn...

Intravenous nanoparticle gene therapy shows activity in stage IV lung cancer

...ath - in cancer cells but is frequently lost when normal cells become cancerous. Lu presented a poster on the study on April 17 at the late-breaking abstract session of the American Association for Cancer Research annual meeting in Los Angeles. Other attempts at gene therapy have employed an adeno...

Computer scientists join in search for ivory-billed woodpecker

...re housed in weatherproof cases. "If you put a normal computer out there, it wouldn't function very long because of the humidity and the rain," Song said. The hard disks are removed routinely from the computer by birdwatcher M. David Luneau, associate professor in the University of Arkansas at Littl...

Strawberry daiquiris -- the extra-healthy cocktail?

...free radicals produced naturally during a person’s normal metabolism. Those who aren’t keen on strawberry daiquiris might be relieved to know that the scientists found similar results with blackberries, meaning that a blackberry-crowned champagne cocktail might achieve the same effect. ...

Cancer researchers add spice to research against rare neuromuscular disease

...gnosed in their 30s and 40s, and while most live a normal life span, many patients end up using a wheelchair... up inside neurons, creating a clog that can bring normal molecular activity to a standstill. The clumps of material eventually become toxic to neurons. In...

Computer imaging assists with facial reconstructive surgery

... These changes brought the patients closer to the normal range for these measurements and angles. “Surgery for facial disharmony requires artistic judgment and objective evaluation,?the authors conclude. “For surgeons who use computer imaging software, analysis of profile photographs is the most valuab...

Parasite infection may benefit MS patients

...parasite infection can result in a decrease in the normal inflammatory response associated with MS. They note that evidence for production of regulatory T cells (which inhibit the immune response) in parasite infection is now emerging, which offers an explanation for the mechanism by which infected hosts ex...

Protein found to shield pancreatic cancer cells from self-destruction

...general, you rarely see overexpression of TG2 in a normal cell," says Kapil Mehta, Ph.D., professor in the M...lled apoptosis. Apoptosis, like autophagy, is a normal biological defense mechanism that systematically destroys defective cells by forcing them to kill th...

Termites get the vibe on what tastes good

...eding termites. By offering them a choice between normal wooden blocks and specially designed blocks made o... "When offered a choice between blocks of their normal wooden food, and specially engineered blocks made of wood and other materials, they could tell when ...

Active ingredient in common Chinese herb shown to reduce hypertension

...nsion, that is, blood pressure measuring above the normal range (less than 120/80 mmHg). If untreated, it can lead to heart attacks, strokes, or kidney disease. Lifestyle changes are the first-stage treatment for the disease, but if they fail, medications are prescribed. Many patients with high blood ...

Scientists uncover new target in cancer mutation puzzle

...s highly active only in malignant cells and not in normal cells. "Now that we understand more about the role of Rho proteins as a target of cooperating cancer gene mutations in tumors with p53 mutations, we will look for other molecules with similar features," Land said. "Our hope is that this line of re...

Brain networks strengthened by closing ion channels

...nt of drug therapies for the cognitive deficits of normal aging, and for cognitive changes in schizophrenia,...maintain such memory-based functions declines with normal aging, is weakened in people with ADHD, and is severely disrupted in disorders such as schizophrenia...

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