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Tag: "normal" at biology news

Robotic therapy helps restore hand use after stroke

...therapy device may help people regain strength and normal use of affected hands long after a stroke, according to a University of California, Irvine study. Stroke patients with impaired hand use reported improved ability to grasp and release objects after therapy sessions using the Hand-Wrist Assisting ...

New protein inhibitor impedes growth of cancerous cells

... have lost some of the restraints on division that normal cells impose on themselves. Because central aspect...I 2536 as a tool to probe the functions of Plk1 in normal cells. The availability of a specific Plk1 inhibitor is particularly useful in this regard because P...

Angelman syndrome deficits rescued in mice

...ordination. The double mutants, however, showed normal learning and memory and motor coordination. And while the Angelman mice were also prone to seizures, the double mutants showed very low seizure susceptibility. Weeber was surprised by the robust results. "We thought we might rescue some of the def...

Shedding new light on proteorhodopsin

...on green light illumination. In the control study, normal E. coli cells, which do not not express proteorhodopsin, had no response to the green light. The next step in this work, Liphardt said, is to optimize the amount of light that can be collected in cells enhanced with proteorhodopsin. For this the r...

First-degree fetal heart block may be reversible

...manent heart damage can occur within one week of a normal echocardiogram, even a weekly evaluation may not be sufficient to detect early onset of disease." ...

Why doesn't the immune system attack the small intestine?

... tissue. The immune system distinguishes between normal and foreign agents by small proteins, called antig...n as dendritic cells display the antigens of their normal neighbors in a way that puts the immune system "at ease." By reading those antigens without being o...

Biologists develop large gene dataset for rice plant

...ed approaches, Meyers and colleagues examined both normal gene expression (via messenger ribonucleic acids, or mRNAs) as well as small ribonucleic acids (small RNAs) in rice. The analysis of rice was based on gene sequences representing nearly 47 million mRNA molecules and three million small RNAs, a lar...

Novel antigen-cloning technique may boost efforts to develop a melanoma vaccine

...lved in protein synthesis and is also expressed in normal cells. Herlyn's study shows that RPL8 is over-expressed not only in melanoma, but also in breast cancer cells and gliomas, the most common type of brain tumor, indicating that it has potential as a vaccine for patients with these tumors. In their ...

Researchers discover gene crucial for nerve cell insulation

...as early growth response gene 2 (EGR2) affects the normal copy of the gene as well as the functioning of oth...y of the EGR2 gene disrupts the functioning of the normal EGR2 gene, leading to a disorder of the nervous system. In many genetic conditions, the unaffecte...

Scientists find new genes for Crohn's disease

...gene, which they found is essential for the cell's normal mechanism for degrading worn-out cellular components and helping to eliminate some pathogenic bacteria—a pathway known as autophagy (pronounced AU-TOF-A-GEE ). Finding ATG16L1's involvement in Crohn's disease provides confirmatory evidence for wh...

MicroRNAs as tumor suppressors

...d with human tumors, the researchers found that in normal cells, a microRNA called let-7 binds to the 3?end of the HMGA2 mRNA transcript and suppresses its expression in the cell cytosol. However, chromosomal breaks that shorten the 3?end of the HMGA2 transcript, and prevent let-7 binding, result in aberran...

Researcher to study astronaut bone loss for space biology agency

...ew bone cells to replace old cells that die in the normal course of bone metabolism. After their return to Earth's gravity, an event known as reloading, bone cell production can take months to return to normal. During that time, bones are highly vulnerable to fracture. Here on Earth, explains Bikle, imm...

New cell type identified in cancer development

... cells and tissues. These cells are different from normal stem cells, however, in that injecting even as few...id cells are very complex. They have properties of normal and abnormal stem cells, and do not always lead to cancer ?only some of the time, and under very spe...

Protein overexpression at heart of heart failure

...Intracellular [Ca2+]i homeostasis is essential for normal cardiac function and integrity, and dysregulation of [Ca2+]i is a hallmark of advanced heart failure.2 The primary trigger for cardiac [Ca2+]i transients is calcium entry through the pore subunit of the voltage-dependent L-type channels (L-VDCC), but...

Scientists sequence genome of parasite responsible for common sexually transmitted infection

...including the bacteria necessary for maintaining a normal healthy environment in the vagina. As a result, women infected with trichomoniasis become more susceptible to becoming infected by HIV and other STIs. In generating the genetic blueprint for the parasite, researchers were surprised to find such a ...

Scripps research study reveals structural dynamics of single prion molecules

...ademy of Sciences, offer significant insights into normal folding mechanisms as well as those that lead to abnormal amyloid fibril conversion. The new insights may lead to the discovery of novel therapeutic targets for neurodegenerative diseases. Intriguingly, certain prions and amyloids can play beneficia...

New molecular pathway could reveal how cells stick together

...inflammatory conditions," Page-McCaw said. Yet the normal function of these proteins is not well understood.... goes wrong without the protein and then infer the normal function of that protein. She has previously done similar work knocking out MMP in flies. "One o...

Tracing broken wiring in stroke patients

...gions of the brain where there was a disruption of normal functional brain circuitry. In their experiments, the researchers used FC MRI to study the brains of 11 stroke patients with neglect, both at one month and at more than six months after their strokes. While the patients' brains were being scanned,...

Gene that makes people 'early to bed and early to rise' demystified

...y show that the human gene inserted into otherwise normal mice causes them to rise early, symptoms that mirr... sleep disorders--might take a pill and be back to normal again," Fu said. "When we fly to Europe, we set our watch ahead several time zones and our watch i...

Scripps research team discovers a chemical pathway that causes mice to overeat and gain weight

...e EP3 receptor tend to be more active during their normal sleep cycle and to eat more. In the study, this led to weight increases of up to 30 percent relative to mice with the receptors. The EP3 receptor is one of four types of receptors for prostaglandin E2 (PGE2), the most important inflammatory mediato...

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