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Tag: "normal" at biology news

St. Jude study solves mystery of mammalian ears

...ls contract in response to incoming sound waves as normal prestin does. Instead, the mutated form of prestin makes the cell extend itself when it vibrates. The St. Jude researchers reasoned that if altering the position of the cilia in the fluid changes the ability of the cilia to amplify sound, then hear...

Carnegie Mellon scientists find key HIV protein makes cell membranes bend more easily

...nergy of manufactured lipid bilayers made to mimic normal cell membranes. Lipid bilayers provide a protective barrier for the cell against intruders, yet also contain molecules to recognize and communicate with other cells or get nutrients. Cells also communicate with one another via small, membrane-bound v...

Scratch no more: Gene for itch sensation discovered

...at lacked this gene scratched much less than their normal cage-mates when given itchy stimuli. The laborato...GRPR gene to find out how they were different from normal mice. "The research was a little disappointing at first," Chen says. "The knockout mice seemed to h...

One species, many genomes

...ene was so defective that it could not fulfill its normal function anymore! Results such as these raise fundamental questions. For one, they qualify the value of the model genomes sequenced so far. "There isn’t such a thing as the genome of a species," says Weigel. He adds "The insight that the DNA sequ...

Cellular message movement captured on video

...g molecules may attach to paxillin and disturb the normal adhesion and growth factor signaling steps require...of these processes, we can not only understand how normal cells function, but we can also look at diseased cells to see why they sometimes don’t move properly...

Agent slows aging in mice

... the journal Aging Cell, show that male mice fed a normal diet and NDGA so far have survived in significantly greater numbers than mice on a normal diet. Scientists measured the difference at a point called median lifespan, when half the control mi...

Cells re-energize to come back from the brink of death

...ude study was conducted in culture dishes in which normal cells were exposed to cancer drugs or other agents that triggered apoptosis. The researchers then blocked apoptosis in order to study CICD. “The GAPDH response appears to represent a basic, reproducible event. But in order to verify that hypothesis, ...

Gene therapy delivery of nerve growth factors reverses erectile dysfunction in animal model

...er of two nerve growth factors were able to regain normal function after four weeks, according to a study conducted by University of Pittsburgh School of Medicine researchers. These findings are being presented at the 10th annual meeting of the American Society of Gene Therapy, which is convening May 30 to ...

How sneaky HIV escapes cells

... experiment, Gould and his team added chemicals to normal human cells that force nearby proteins together in...biology, which can yield a better understanding of normal human biology as well as identify new avenues in the fight against human disease.” ...

Research team identifies new Alzheimer's gene

...archers hypothesize that GAB2 might function under normal conditions to compensate for the harmful effects of APOE4 and other genes in older people and that the GAB2 risk gene lacks this protective effect. The study, funded by Kronos Science Laboratory, an affiliate of Phoenix-based Kronos Optimal Healt...

Millions of children denied drug that costs less than $3 a year

...ople, many of whom are children, could return to a normal life by taking a single daily dose of a drug (phenobarbital) that costs less than $3 (£1.5; €2.2) each year. The World Health Organisation recommends phenobarbital as the treatment of choice in resource restricted countries, but this policy has be...

In mice, drug protects against diabetes and atherosclerosis

...appears to have no effect on lean animals eating a normal diet, the scientists said, suggesting that blockin...odel of obesity and insulin resistance, as well as normal mice fed a diabetes-inducing diet. In both animal models, the mice that received the inhibitor dr...

Breakthrough developments in rheumatoid arthritis reported

...effort to release large amounts of genetic data on normal subjects for use by the scientific community. A ke...icists is the costs of obtaining genetic data from normal control populations to use for comparison to the genetic variation seen in people with disease. ...

Newly discovered antibody may be body's natural defense against Alzheimer's

...be present in substantial quantities in blood from normal humans. Lead researcher Dr. Norman Relkin, a b... that these antibodies are present in the blood of normal individuals. The basis for the selective recognition of oligomers by these antibodies appears t...

Researchers reveal structure of protein altered in autism

...derstanding the three-dimensional structure of the normal protein, researchers can now make predictions about how mutations in the gene affect the structure of the gene product,” said first author Davide Comoletti, Ph.D., UCSD research associate at the Skaggs School of Pharmacy. Autism spectrum disorders...

Penn researchers link cell's protein recycling systems

...ulating in nerve cells, suggesting that the cell’s normal disposal mechanisms are not operating correctly. Now, researchers at the University of Pennsylvania School of Medicine have discovered a molecular link between the cell’s two major pathways for breaking down proteins and have succeeded in using this ...

Cancer stem cells similar to normal stem cells can thwart anti-cancer agents

...have shown share the same protective mechanisms as normal lung stem cells. They are presenting this ground-b... and dyes to identify cancer stem cells as well as normal adult stem cells and their progeny in samples obtained from normal lung and lung cancer tissue sampl...

Mutating the entire genome

...mouse on the left, compared with the skeleton of a normal mouse on the right. The new method promises to spe... to see what goes wrong, thus revealing the gene’s normal function and how disease makes it malfunction. But DNA regulatory sequences between genes also can m...

Researchers demonstrate way to control tree height

...ble to create miniature trees that look similar to normal trees – but after several years of growth may rang...pread, because they would compete very poorly with normal or wild trees. In virtually all tree species, low height is a disadvantage as trees compete for suns...

Surprising origin of cell's internal highways

...hese drugs influence cancer cells differently than normal cells," said Kaverina. "Both microtubule regulation of proliferation and microtubule regulation of migration and invasion probably contribute to the therapeutic effects." Therefore, further study of this new subset of microtubules might offer ins...

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