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Tag: "nodes" at biology news

Georgia Tech accelerates drug discovery with new IBM supercomputing cluster

... cluster of 1,000 AMD Opteron processor-based LS20 nodes for IBM BladeCenter systems (total of 4,000 core p...ors) running Red Hat Linux 4 on the infrastructure nodes and Scientific Linux on the compute nodes. The supercomputer forms the basis of the IBM Cluster 1350...

Chemical guidance of T cells leads to immunologic memory and long-term immunity

...croscope to document what happens inside the lymph nodes of a living mouse shortly after a vaccination. The...erstanding how CD8+ T cells move through the lymph nodes and become activated. Once active, CD8+ T cells roam throughout the body destroying cells infected w...

Front-line immune cells mature in four stages, study shows

...zed tissues from more than 50 tonsils and 30 lymph nodes from the OSUCCC Tissue Procurement Shared Resource...ecisely where they mature within tonsils and lymph nodes and whether they play a role in immune responses or are just going through the maturation process. ...

Manipulating single cell receptor alters animal behavior

...and the intracellular events that occur at various nodes within the circuits pathways. In addition to the publication of this study in Endocrinology, his work has been published in journals such as the Journal of Neuroscience, Brain Research, Hormones and Behavior, Neuroscience Letters, Peptides, Physiol...

Malaria parasites develop in lymph nodes

...lymph nodes. The parasites' presence in the lymph nodes almost certainly has implications for the mammalia...drained by lymphatic vessels and ended up in lymph nodes close to the site of the bite. Their journey seemed to stop there, as the malaria parasites almost n...

Simple idea to dramatically improve dengue vaccinations

...aking advantage of the relative isolation of lymph nodes throughout the body. Each person has hundreds of lymph nodes. Deem believes vaccinations at four different sites, served by four different lymph nodes, could allow the body to simultaneously develop immune responses against all four versions of Dengu...

New evidence questions the simple link between prion proteins and madcow disease

...t tissues to accumulate infectivity would be lymph nodes in the throat or the tonsils. But we don't tend to see this in animals, and have no reason to believe it would be different in humans," comments Jeffrey. ...

Source of crucial immune cell in the skin discovered

... these cells to transport the antigen to the lymph nodes to trigger an immune response against the tumor." Once Langerhans cells transport an antigen, they need to be replaced to maintain the tight network in the skin. Dr. Merad and colleagues at Mount Sinai School of Medicine recently discovered that whe...

Scientists directly view immune cells interacting to avert autoimmunity

...ct the therapeutic regulatory T cells to the lymph nodes so they interact with dendritic cells before the autoimmune T cells are able to, and thereby "stamp out the initial sparks" before the disease spreads to the tissue. Krummel notes that the research dispels some assumptions about cellular movement ...

New evidence supports century-old theory of cancer spread

...ophages, including the ability to migrate to lymph nodes and distant organs and to form a new blood supply. Our data indicate that they do this by hybridizing with macrophages," said lead author John Pawelek, research affiliate in the Department of Dermatology at Yale School of Medicine and a member of Yal...

Jefferson biologist coaxing human embryonic stem cells to make dopamine with simpler, faster method

...distance from the tumor, spring into action. Lymph nodes are a critical part of the immune system, helping to recruit key disease-fighting immune cells. "This lets us see not only how but where" the body is responding to disease, Witte explained. "The immune system resides throughout the body, and it is n...

PET imaging reveals the immune system at work

...distance from the tumor, spring into action. Lymph nodes are a critical part of the immune system, helping to recruit key disease-fighting immune cells. "This lets us see not only how but where" the body is responding to disease, Witte explained. "The immune system resides throughout the body, and it is n...

Magnetic probe successfully tracks implanted cells in cancer patients

...accurately guide injection of the cells into lymph nodes in half of the patients," says Bulte, an author on...ed to be is to inject them directly into the lymph nodes that drain the area containing a tumor. Currently, doctors use ultrasound to guide the needle, and d...

Discovery of T-cell 'traffic control' boosts new drug promise

...he trafficking of T cells through the blood, lymph nodes and on to tissues to fight infection -- a crucial ...They slow the flood of T cells "called into" lymph nodes by chemokines. The scientists made a second discovery about T cell movement: S1P, like chemokines, ...

Compound might defeat African sleeping sickness, clinical trial beginning this month

...uman by tsetse fly bites. It produces fever, lymph nodes inflammation, eventual impairment of the brain and nervous system in its late stage and, if not treated, death. The World Health Organization has estimated that more then 300,000 people are infected, and more than 60 million living in the region are ...

Natural Killers Could Lead to New Hepatitis Treatments

...n. By contrast, he said, immune cells in the lymph nodes and spleen perform their surveillance ensconced within specialized compartments shielded from the turmoil of the bloodstream. “In this case, it looks like NKT cells are doing their surveillance from within the vessels,?he said. The observations reve...

Internet viruses help ecologists control invasive species

...rk theory, they built up a picture of the lakes as nodes in a network connected by human traffic, including boat trailers and anglers. Like internet viruses, which spread fastest when they attack the most widely-used email programmes, Muirhead and MacIsaac examined patterns of human vector movement to see ...

A little stress gives beneficial oomph! to immune system

... stations ?primarily the skin along with the lymph nodes that drain the skin. "Most immune challenges or wounds involve on the skin or other epithelial linings of the body," Dhabhar said. "If nothing happens immunologically following stress ?the skin isn't cut or wounded in some other way ?activated leuko...

Scientists identify new model Of NK cell development

...d noted other work showing that mice lacking lymph nodes also lacked NK cells. In addition, in earlier rese...ight subset appeared much more frequently in lymph nodes than in bone marrow or circulating blood. In other words, they had a hunch traditional thinking abo...

New Mixing Method for Microchip-Sized Labs

... Mills. “But Iand others believe there are central nodes between these intersectingcircles that can be effectively targeted with drugs.?Only one PI3K pathway inhibitor is in use to date, but others areincreasingly being developed and tested, says Mills, who is discussingthe importance of this pathway at th...

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