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Tag: "nodes" at biology news

New bacterium discovered -- related to cause of trench fever

...ch disease, an infection that causes swollen lymph nodes and fever after a cat scratches its owner or an unlucky visitor. They were again surprised to find that this microbe is the second Bartonella species to cause infection in AIDS patients. Like trench fever, cat scratch disease had been described ...

How 'memory' T cells curb the spread of viruses throughout the body

...cademy of Science Online Early Edition shows lymph nodes are not just organs where immune cells reside and ... CD8 T cells needed first to multiply in the lymph nodes and then migrate through the blood to kill infected cells at the site where the virus entered the bo...

Molecular differences between early and advanced melanomas could provide new drug targets

...to 64 percent if the disease has reached the lymph nodes and 16 percent if it has spread to other organs. The discovery of Akt's significant role in the progression of melanomas was made by scientists in the Department of Dermatology at Emory University School of Medicine and published in the March issu...

Why doesn't the immune system attack the small intestine?

...says Turley. "Because the cells are found in lymph nodes throughout the body, they may offer a way of suppressing a variety of autoimmune diseases," which result from immune system assault on healthy tissue. The immune system distinguishes between normal and foreign agents by small proteins, called antig...

Napoleon's mysterious death unmasked, UT Southwestern researcher says

...accounts indicate that the cancer was large, lymph nodes were present around the stomach and there were no tumors in other organs. Only 20 percent of patients with Stage IIIA gastric cancer survive five years if treated with modern surgery and chemotherapy. But what might have caused Napoleon's cancer? ...

Lab research may one day lead to cancer treatment using patient's own immune cells

...dentifying and harvesting T cells within the lymph nodes of patients, activating these T cells and growing them in culture in the laboratory over one to two weeks. The T cells are activated with molecular agents called interleukin-2 and anti-CD3 antibody (OKT3). It is hoped that results from this rese...

Short chromosomes put cancer cells in forced rest

...closer look showed microtumors in the mice’s lymph nodes that had begun the road to cancer, but stopped, falling instead into a state of senescence. "They don’t die, they don’t divide, they just sit there in permanent rest," says Greider. Greider, who won the Lasker Award in 2006 for her discovery of t...

Ring-around-the-cell

...just seals. They appear to act as highly connected nodes of communication between the inside and outside of the cell, enabling the cell to adjust its activity according to the condition of the bone underneath." ...

Radiation after surgery doubles survival time for some lung cancer patients

...h lung cancer that has spread to mediastinal lymph nodes ?located between the chest, breastbone and spine ?...l cell lung cancer with involved mediastinal lymph nodes in addition to chemotherapy. The data observed in this study, however, needs to be confirmed in a pr...

Novel vaccine shows promise against early-stage breast cancer

...eceived four weekly vaccinations into normal lymph nodes in their groins and were evaluated both pre- and post-vaccination for immune response, level of HER-2/neu expression, and cell infiltrates. The researchers found that most patients responded well to the vaccination. Nearly all patients (11 of 12) ...

Novel mechanism of action of new drug for MS identified

...ing the egress of white blood cells from the lymph nodes into the blood. The article was pre-published as a First Edition Paper in Blood, The Journal of the American Society of Hematology, which appeared online on Sept. 28. In this study, the research team observed that FTY720 also inhibited the activity...

Spelling out cancer on the nanoscale

...s of MYC, BCL2, ERK, and AKT proteins in the lymph nodes obtained from patients with Burkitt’s, mantle cell, or follicular lymphoma. The nano-fluidic system reported that MYC was overexpressed in Burkitt’s, while BCL2 was overexpressed in mantle cell and follicular lymphoma patients. In parallel, tradition...

HIV exploits competition among T-cells

...roach capitalizes on the fact that different lymph nodes ?the sites where T cells compete to be chosen as the winners against a particular disease ?act as collection points for different parts of the body. Moreover, because it takes 4-5 days for T cells produced in a lymph node to begin to leave it, the po...

Tumor wizardry wards off attacks from the immune system

... T-reg cells in both the blood stream and in lymph nodes leading from the tumors. When the research team blocked a signaling molecule that pancreatic tumors secrete in abundance, T-reg cells were no longer present in the tumor-draining lymph nodes, suggesting that this signaling molecule, referred to as ...

First-ever genomic test predicts which lung cancer patients need chemotherapy to live

... the patient's tumor, whether it has invaded lymph nodes and whether it has spread to other organs. They use this staging method to prescribe the best treatment options. But staging parameters are general, at best, and do not accurately define who should receive chemotherapy, Nevins said. "Instead of pl...

UC Davis researchers move biotechnology closer to replacing electronic pacemakers

...hers used radiofrequency ablation to remove the SA nodes in pigs' hearts. This is the same minimally invasi...sfer, the pigs' hearts had generated bioartificial nodes at the injection sites. Li explained that, through gene expression, normal muscle cells of the heart...

APS lecturer shows rare video of 'teacher-student' immune cell interactions in live animal

...king, particularly in the lymph nodes." The lymph nodes are the school, the dendritic cells the teachers and the T cells the students, von Andrian explained. Dendritic cells find foreign invaders, rip them apart and bring the pieces (antigens) via the lymphatic system to the nearest lymph node. When the d...

Avian flu modeled on supercomputer, explores vaccine and isolation options for thwarting a pandemic

...le-system image Linux cluster in the world. Pink's nodes have dual 2.4 GHz Intel Xeon processors (Pentium 4) with 2 gigabytes of memory per node. The purchase of the Science Appliance was funded by the National Nuclear Security Administration's Advanced Simulation and Computing program. Pink is currently a...

Soil-bound prions that cause CWD remain infectious

...the new bacterium from the patient's swollen lymph nodes and demonstrated its pathogenesis. "Our first concern was to determine whether this organism was truly associated with his clinical syndrome," the team wrote. Despite ineffective neutrophil immune cells, the patient's immune system still tagged ...

Scientists discover a new disease-causing bacterium in an immune-compromised patient

...the new bacterium from the patient's swollen lymph nodes and demonstrated its pathogenesis. "Our first concern was to determine whether this organism was truly associated with his clinical syndrome," the team wrote. Despite ineffective neutrophil immune cells, the patient's immune system still tagged ...

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