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Tag: "nitric" at biology news

Heart-healthy compound in chocolate identified

...dwellers had more than twice the levels of urinary nitric oxide -- a chemical compound already known to be a...udy the researchers demonstrated that: Levels of nitric oxide in the blood were higher in individuals who drank flavanol-rich cocoa, compared to those who d...

Common bacteria pirate natural mechanism to get inside cells

...o have found that the short-lived, ubiquitous gas, nitric oxide, is a primary enabler for receptors and path...illions of receptors on the cell surface. "Adding nitric oxide to dynamin changes it from an inactive protein inside the cell to the active protein that medi...

Newly identified mechanism helps explain why people of African descent are more vulnerable to TB

...riments -- combat microbes such as TB by producing nitric oxide in scavenger cells of the immune system known as macrophages. However, this mechanism is not prominent in humans, and the mechanism by which human macrophages kill the tubercle bacillus has remained an additional puzzle. Innate immunity is the...

Phenolic compounds may explain Mediterranean diet benefits

...ns of certain components in blood serum, including nitric oxide, improved after the polyphenol-rich breakfas...uction in oxidative stress and the increase in the nitric oxide bioavailability are behind the observed improvement in ischemic reactive hyperemia," Dr. Pérez...

Bare metal stents deliver gene therapy to heart vessels with less inflammation in animal studies

...apeutic gene that encodes for a protein, inducible nitric oxide synthase (iNOS), in the carotid artery studies, because of iNOS's ability to control cell damage in blood vessels. "However, in further studies, one might use a combination of therapeutic genes or different gene vectors, for even better results...

Stem cells bring fast direct improvement, without differentiation, in acute renal failure

...F-alpha, and IFN-gamma, as well as iNOS (inducible nitric oxide synthase), and upregulation of anti-inflammatory and organ-protective interleukin-10, as well as bFGF (basic fibroblast growth factor), TGF-alpha (transforming growth factor alpha) and antiapoptotic Bc1-2," the paper added. Beneficial paracrin...

Visceral Leishmaniasis: Successful Vaccine Trial In Dogs

.... These induce the infected macrophages to produce nitric oxide, highly toxic for cells. This process, which did not occur in the untreated dogs, thus enables macrophages to get rid of the parasites that are infecting them. The animal thus acquires long-term protection against visceral leishmaniasis. Altho...

Physical and functional interaction of key cell growth molecules linked to cancer

...nteraction leads increased expression of inducible nitric oxide synthase (iNOS). Although elevated iNOS is also a key characteristic of many human malignancies, there has previously been no direct connection made between EGFR and the iNOS/NO pathway. The researchers conclude that the complex formed by EGFR...

Researchers uncover E. coli's defense mechanism

Iron key to nitric oxide reductionResearchers at the Georgia Institut... a mechanism that allows bacterial cells to detect nitric oxide and turn it into something that's harmless to the cell," said Stephen Spiro, associate profess...

Newly Discovered 'Branding' Process Helps Immune System Cells Pick Their Fights

... putting out chemically unstable compounds such as nitric oxide and superoxide. Together, these compounds generate peroynitrate, a highly potent chemical that modifies many proteins. Unanue's group showed that this chemical modifies the peptides presented by antigen-presenting cells in several distinct way...

Researchers report new pro-inflammatory role for anti-inflammatory enzyme

...tory response to bacterial invasion is to increase nitric oxide levels with an enzyme called inducible nitric oxide synthase. In a study published in the Journal of Biological Chemistry, scientists report that ...

Disease diagnosis, biodefense among UH chemical research projects

... heme proteins found in certain insects that store nitric oxide (NO). Having importance in many areas of human health, NO is useful in lowering blood pressure, treating cancer and increasing oxygen absorption in lung tissue. Czernuszewicz's research is focused on the roles of salivary nitrophorins in storin...

Discovery Promises Simpler Therapy for Sickle Cell Disease

...ells to relax blood vessels through the release of nitric oxide is a major factor behind the disease's prima...in, clots and stroke. Thus, therapies that restore nitric oxide to blood cells might serve as a useful method for treating the disease, said HHMI researcher J...

Polymers with copper show promise for implanted sensors

...y with intravascular sensors that were coated with nitric oxide-releasing polymers has promising preliminary... strategy: creating polymer coatings that generate nitric oxide from components already in the blood. U-M chemistry professor Mark Meyerhoff will discuss the ...

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