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Wisconsin scientists grow critical nerve cells

...e studies from animal to humans," says Zhang. The next step, Li says, will be to test if the newly generated neurons can communicate with other cells when transplanted into a living animal. The team will first test the neurons in chicken embryos. While the new results are promising and provide access to...

W.M. Keck Foundation funds study of friendly microbes

... interdisciplinary enterprise strategically placed next to the Genome Sequencing Center. It is a major facet of the University's BioMed 21 initiative, which aims to translate genomic science into patient care. The CGS plays a catalytic role in helping to devise new ways to translate the genetic data obtai...

Priming embryonic stem cells to fulfill their promise

...rrow $3 billion to fund stemcell research over the next 10 years."I'm really excited about the stem cell applications of our newtechnology," said Bhatia. "We feel that this extracellular matrix partof the stem cell niche has been understudied. If we can now take whatwe've learned, add combinations of grow...

Tiny particles could solve billion-dollar problem

...d the Georgia Institute of Technology, will appear next month in the journal Environmental Science and Tec...y of these catalysts in breaking down TCE, and the next step is engineering a system that will allow us to get at the polluted groundwater," said Joe Hughes...

Study Demonstrates Gene Expression Microarrays are Comparable and Reproducible

...es. Measurement errors common to all labs were the next mostcommon contributor, and biological differences in different sampleswere the largest source of variation.“This study indicates that microarrays have a high degree ofreproducibility, as long as standardized protocols are carefullyfollowed,?said Jac...

Bound for destruction: Ubiquitination protects against improper Notch signaling

...me of Notch signaling became clearerwhen the group next turned to examine the interaction between Nedd4 andDeltex (Dx), a putative ubiquitin ligase known to bind and activate theNotch receptor. Hayashi’s group found evidence that Nedd4 and Dx viewith each other to regulate Notch activity during endocytosi...

U-M scientist to talk about tissue engineering at AAAS

...ination therapy approach works, Krebsbach said the next step would be working with engineers to develop anatomically correct scaffolding with the same curvature and contours of natural bones. That would help a patient develop new bone almost indistinguishable from nature's original equipment. Many resear...

The secret lives of whales

...ppear to slalom from one geographic feature to the next using the echoes of their intense, infrasonic voic...,?says Payne. Payne’s greatest hope is that in the next decade, the world will have taken heed, and instituted steps to reduce the entry of contaminants to ...

Researchers reveal the infectious impact of salmon farms on wild salmon

...orship of the migrating salmon," says Lewis. "The next step is to thoroughly investigate the degree of impact on wild populations," adds Krkosek. The authors concur that their findings point to a need to reconsider the premise of industrial scale fish farming in wild salmon habits. "There's a double bot...

Novel Therapy Tested in Mice Could Chase Away Cat Allergies

...he immune cells from reacting to cat allergen. The next step was to test GFD in mice that we had made allergic to the allergenic protein found in cat saliva and dander.?/p> The researchers tested GFD in two different types of allergic mice. One set was genetically engineered to have human cat-allergy ...

Clam embryo study shows pollutant mixture adversely affects nerve cell development

...fact, Reinisch and Kreiling have already begun the next phase oftheir work. They are currently examining the origins of BCE toxicity atthe single-neuron level to learn what genes are turned on and off bythe exposure to the chemical mixture. The research is focused on afamily of genes known as P53, which h...

Female sex hormones play a vital role in defense against sexually transmitted diseases

...ending these findings into clinical studies is the next step. McMaster researchers are currently discussin...ns in Hamilton, which may begin in as early as the next few months. Additionally they will be looking at issues of co-infection with both HIV-1 and HSV-2 wh...

Study identifies predictors of HIV drug resistance in patients beginning triple therapy

...fact, Reinisch and Kreiling have already begun the next phase oftheir work. They are currently examining the origins of BCE toxicity atthe single-neuron level to learn what genes are turned on and off bythe exposure to the chemical mixture. The research is focused on afamily of genes known as P53, which h...

An HIV Protein Plays a Surprising Role in Gene Activation

...ivate transcription. The big surprise came in the next round of experiments, which explored Tat's influence on transcription and PIC assembly on the HIV promoter. As expected, transcription factors were “virtually undetectable?at the core promoter in the absence of Tat. Adding Tat recruited all the usual...

Spider Venom Could Yield Eco-Friendly Insecticides

... charged molecules -- across cell membranes.) His next challenge is to use this information to design insecticides that specifically target insect pests without affecting vertebrates. One approach is to create chemical insecticides that mimic the action of spider toxins. Many insects have developed immun...

First-ever Compounds To Target Only Metastatic Cells Are Highly Effective Against Breast, Prostate, And Colon Cancers

...two important steps," Dr. Huang said. Dr. HuangÕs next important step is moving these analogues into clinical trials. "We're trying right now to get a company interested in this, especially because the mice used in our trial seemed to experience minimal toxicity -- a good sign that patients might tolera...

Scientists develop new color-coded test for protein folding

...r signs of infection in the blood stream. Over the next few months, he and his colleagues plan to re-do the experiment using other protein molecules. ...

Nanogen Issued Patent for Electronic Microarray With Memory

...h cancer, cardiovascular and genetic diseases. The next generation instrument system, the NanoChip(R) 400, is expected to be available in 2005. Nanogen's subsidiary SynX offers a line of point-of-care diagnostic tests and is building expertise in cardiac related health conditions. Nanogen's ten years of p...

Why do insects stop 'breathing'? To avoid damage from too much oxygen, say researchers

...hey are regulating oxygen." Bradley and Hetz will next work on developing a comprehensive model of insect breathing. "We'd like to expand our present model to explain all aspects of insect breathing. And we'd like to examine insects that do not show this pattern -- for example, desert beetles. While we h...

Scientists discover unique microbe in California's largest lake

...hesis, but its exactfunction is still unknown. The next challenge, Miller says, will be todetermine whether this example of instant evolutionary innovation bygenetic exchange has in fact had consequences for ribosome function inthese bacteria.The new species of Acaryochloris is the latest in a series of n...

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