Simulations unravel outer membrane transport mechanism
... the job of hauling large molecules inside. The new study examined an outer membrane transport system that depends on an energy-generating inner membrane protein, TonB. This TonB-dependent transporter (TBDT) contains a beta-barrel domain: a series of parallel sheets that form a tunnel through which la......sport system to leave one infected cell and infect new ones, Hopkins scientists have discovered. Their fi...anding of normal human biology as well as identify new avenues in the fight against human disease.” ...The insect vector always bites twice
...es, constitutes now an important research path for new surveillance and prevention strategies. ...A new plant-bacterial symbiotic mechanism promising for crop applications
...teria of the Rhizobia family, have just revealed a new mode of communication at molecular level between these two organisms. The bacteria of this original model have their own photosynthetic pathway, a unique property in the rhizobia (2). This special character confers on it the exceptional, rare ability...Hormone helps mice 'hibernate,' survive starvation
...prove to be a vital part of the ongoing search for new therapies for human obesity and other metabolic co...ce the amount of fat in the blood, we believe this new pathway may lead to a new class of drugs that will impact many human conditions,” he said. ...Research team identifies new Alzheimer's gene
...expected to triple by 2050. “We have entered a new era in medical research. Today’s technologies perm...and disease mechanisms, the discovery of promising new disease-slowing and prevention therapies, and the identification of patients and at-risk people most...Envisat captures first image of Sargassum from space
...m and Antarctic super blooms. It really gives us a new and unique view of the Earth." Gower and King ...orithm and powerful Grid computing to broaden this new view. The basic principle behind Grid computing is that anything one computer can do, a pool of comp...Largest synthetic gene ever built offers insights into anti-malarial drug resistance
...there, and then ruptures liver cells, spewing many new parasites into the blood. A fever results from the infection, and this is followed by repeated cycles of mounting parasitic reproduction within red blood cells and accompanying fever. During red blood cell infection, P. falciparum degrades the hemogl...Loss of stem cells correlates with premature aging in animal study
...y divide and are able to replenish the tissue with new cells. Brown explains that in the current stud... subsequently age before their time.” With this new knowledge of how DNA repair, stem cells, and the aging process interconnect, Brown, first author Yar...Pesticides choke pathway for nature to produce nitrogen for crops
...ibuting to growth problems, scientists report in a new study. According to years of research both in the test tube and, now, with real plants, a team of scientists reports that artificial chemicals in pesticides – through application or exposure to crops through runoff – disrupt natural nitrogen-fixin...New bacterium discovered -- related to cause of trench fever
...tective work revealed that she was infected with a new bacterium that had never before been isolated from...colleagues from other institutions, found that the new microbe is genetically similar to one spread by body lice in the trenches during World War I. That b...Study shows big power of small RNAs, not just proteins, in halting cancer
...NAs to stop tumor cell growth reveals a completely new dimension of this critical cancer fighting pathway and its ability to trigger the genetic death of cancer cells. “Our findings certainly lead to a deeper understanding of a critical tumor suppression mechanism but also may provide insight into how ...In mice, drug protects against diabetes and atherosclerosis
...nother disease associated with obesity. In this new paper, researchers from HSPH, Bristol-Myers Squibb...rd human testing. The important lesson from the new study, the researchers wrote in their report, is the demonstration that aP2 can be blocked by a smal...Longer treatment benefits sleep apnea patients
... to improve breathing during sleep, according to a new study supported by the National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health. This is the first study to identify the nightly duration of CPAP use needed to gain maximum benefit for daytime alertness and functioning. ...Brain holds clues to bipolar disorder
...rvations about the disease. The findings suggest a new avenue for treating the underlying cause of bipola...flare-ups of depression or mania, and also provide new targets, for improved medications many of which are being tested in clinical trials. Mary Phillip...Ancient DNA traces the woolly mammoth's disappearance
Some ancient-DNA evidence has offered new clues to a very cold case: the disappearance of th...en later. In search of a general pattern in the new study, Barnes and Lister’s team looked to the extinct woolly mammoth. What they found, however, was ...Newly found sensing system enables certain bacteria to resist human immune defenses
... these findings may help chart a path to designing new drugs to bolster our antimicrobial treatment optio...er understanding of this system they could develop new drugs that are more effective at protecting people from infection. Likewise, now Dr. Otto and his...Sun exposure early in life linked to specific skin cancer gene mutation
...e to the cause of melanomas has been a mystery. A new clue comes from scientists at the University of North Carolina at Chapel Hill Schools of Medicine and Public Health. Their research indicates that early life sun exposure, from birth to 20 years old, may specifically increase the risk of melanomas wi...Breakthrough developments in rheumatoid arthritis reported
...tests to predict who will respond to the available new treatments. Franak Batliwalla, PhD, also of The Fe...t we have, the more power we will have to pull out new genes and make associations.” In another major breakthrough, scientists have discovered the im...'Lucky 13' as new gene discovery offers further hope for childhood blindness
...ith LCA to restore their sight. The finding of the new LCA gene, based on work funded by the Wellcome Tru...ular Medicine at St James's Hospital, Leeds. "This new gene is the thirteenth and adds a substantial new piece to a growing body of evidence that defects o...