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Tag: "neutralizing" at biology news

Research advances quest for HIV-1 vaccine

...mann Katinger in Vienna and is the broadest acting neutralizing antibody against HIV-1 that is currently known. Th... (IAVI), which is focused on understanding broadly neutralizing antibodies at the molecular level and transferring this knowledge into the design of vaccines capabl...

Muscle-targeted gene therapy reverses rare muscular dystrophy in mice

...erapy method could circumvent the complications of neutralizing antibodies against introduced enzyme, which currently present obstacles to enzyme replacement therapy and liver-targeted gene therapy in Pompe disease," Koeberl said. Clinical trials of either the muscle- or liver-targeted gene therapies will likely...

New Insights Into HIV Immunity Suggest Alternative Approach to Vaccines

...f the HIV virus into people or animals, no broadly neutralizing antibodies ?those antibodies that kill most HIV st.... HIV researchers have attempted to induce broadly neutralizing antibodies ?long-lived, HIV-specific antibodies that can kill all or most HIV strains ?with a simila...

Fragment of yellow fever virus may hold key to safer vaccine

...interact with this part of the protein, known as a neutralizing epitope, to fight off infection. To protect people from the disease, yellow fever vaccines must contain this essential fragment of instruction to the immune system, said ter Meulen, senior author of a study published in the July 5, 2005, issue of the...

Bleach found to neutralize mold allergens

...allergic patients." The need for denaturing or neutralizing mold allergens is a critical step in mold treatment that has not been fully understood. Currently, most recommendations for mold remediation call for removal since dead mold retains its ability to trigger allergic reactions, according to Dr. Martyny....

New study shows SARS can infect brain tissue

...olved," Dr. Jiang said. "Other approaches, such as neutralizing antibodies [and] specific binding peptides, could be tried to block brain damage induced by Mig." Four to five percent of SARS patients treated at the Guangzhou Institute of Respiratory Diseases experienced central nervous system symptoms, said Dr. ...

A radical solution for environmental pollution

...nditions. He'd also like to coax T. aromatica into neutralizing other kinds of pollutants, but the first step is understanding exactly how the bug breaks down toluene. "The challenge is that the chemical reactions these bacteria use are very unusual---not the standard chemical reactions that chemists usually thi...

LIAI scientists make major finding on potential smallpox treatment

...Vaccinia H3L envelope protein is a major target of neutralizing antibodies in humans and elicits protection against lethal challenge in mice" that was published in the September issue of the Journal of Virology. LIAI scientist Shane Crotty, Ph.D., a viral disease expert, led the team of LIAI scientists which mad...

UCSD study finds anthrax toxins also harmful to fruit flies

...vel and may lead to new therapeutic strategies for neutralizing their effects in humans. Annabel Guichard, a biologist at UCSD and lead author of the study, tracked the ways that two active anthrax toxins, known as lethal factor, or LF, and edema factor, EF, cause cellular damage and death in the fruit fly Droso...

H5N1 avian flu virus vaccine induces immune responses in healthy adults

...the 90-mcg, high-dose group, 54 percent achieved a neutralizing antibody response to the vaccine at serum dilutions of 1:40 or greater, whereas only 22 percent of the 100 people evaluated who received the 15-mcg dose developed a similar response to the vaccine. Generally, all dosages of the vaccine appeared to b...

Anthrax inhibitor counteracts toxin, may lead to new therapeutics

...the formation of fully assembled anthrax toxin and neutralizing its activity. The inhibitor protected rats from anthrax toxin in the study. "Our eventual goal is to use the inhibitor as a human therapeutic for anthrax exposure, one that can stop the toxin from functioning inside the body," says Ravi Kane, the M...

Hantavirus found in African wood mouse

... humans, because we identified hantavirus-specific neutralizing antibodies in [the blood] of humans living in the area where the virus was detected. We do not know if these people suffered from an HFRS-like illness, but studies to determine this are in progress." Ter Meulen said, however, that there's little cau...

A large step forward in the fight against African sleeping sickness

...-1 variant to the place where it can carry out its neutralizing action. All the tests performed on mice have been very promising: Trypanosome-infected mice survive after 1 treatment. The parasite is removed from the blood and all effects associated with the disease disappear. There is every indication that this...

UGA study explains peaks and troughs of dengue epidemics

... antibody levels drop to levels that are no longer neutralizing but instead are exploited by the dengue virus to enhance replication and cause more severe illness. "You can't deny the empirical fact that people who get severe dengue may well have had cases before," Rohani said. "But our work suggests it's not t...

Experimental vaccine protects mice against deadly 1918 flu virus

...nst invading viruses, as well as the production of neutralizing antibodies. To determine the vaccine's protecti...cted the mice by stimulating antibodies capable of neutralizing the 1918 flu virus. "Who would have imagined five years ago that we'd be able to create a vaccine ...

Killing the messenger RNA -- But which one?

...genes. They do this by specifically binding to and neutralizing another form of RNA called messenger RNA, responsible for conveying the information from genes to the cellular machinery that uses that information to create proteins, the building blocks of the body. Several hundred species of microRNAs have been id...

Can engineered immune cells stop AIDS?

...ity to hide, HIV often goes virtually unnoticed by neutralizing antibodies that are roaming the body in search of foreign invaders. Faced with such a clever adversary, Wang wants to synthetically alter the HIV invaders and use their hollow shells as delivery vehicles to insert DNA that will counteract the infe...

Scientists unveil piece of HIV protein that may be key to AIDS vaccine development

...ion between the HIV gp120 surface protein and this neutralizing antibody," says NIAID Director Anthony S. Fauci, M...e HIV strains. Scientists have sought such broadly neutralizing antibodies by studying the blood of people whose immune systems appear to hold the virus at bay for ...

New details on how the immune system recognizes influenza

...trains of influenza virus can vary enough in their neutralizing B cell epitopes that a vaccine against one strain may not protect against another strain. But if epitopes are conserved between virus strains, the immunity a person has developed towards one strain might provide at least some protection against the o...

30+ AIDS vaccine clinical trials in 24 countries, research occurring on every continent

...e novel vectors, as well as approaches that target neutralizing antibodies in the next few years," said CEO and President of IAVI, Dr. Seth Berkley. IAVI and its collaborators are currently conducting four ongoing trials in India, Kenya, Rwanda, Uganda, South Africa and the United States. In 2006, IAVI launch...

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