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Tag: "neurodegenerative" at biology news

Newly discovered antibody may be body's natural defense against Alzheimer's

...end against this form of dementia as well as other neurodegenerative diseases. The newly found antibodies selectively...echanism against Alzheimer's and other age-related neurodegenerative disorders," comments Dr. Marc Weksler, The Irving Wright Sherwood Professor of Geriatrics and profes...

Penn researchers link cell's protein recycling systems

...ns and have succeeded in using this link to rescue neurodegenerative diseases in a simple animal model. The study appea...ular link can be used to benefit a wide variety of neurodegenerative diseases because accumulation of toxic proteins is a common underlying feature of age-related neurod...

Gene therapy study shows safety and statistically significant improvement in Parkinson's disease

...fer into a patient’s own brain cells for any adult neurodegenerative disease. The open label Phase 1 study, conducted... other gene therapy approaches to the treatment of neurodegenerative and metabolic diseases. Principal investigators Michael G. Kaplitt, MD, PhD, and Matthew J. During, ...

Salk scientists hammer out a pathway that promotes muscle cell survival in mice

... affect cell survival, such as muscular dystrophy, neurodegenerative diseases, and congestive heart failure." Montminy’s team, led by postdoctoral researcher Rebecca Berdeaux, Ph.D., first became interested in the enzyme when they observed that mice engineered to have a defect in a molecular switch, called cAMP re...

Nitric oxide: Key to cardiovascular and pulmonary function and drug effectiveness

...re, diabetes, atherosclerosis, cystic fibrosis and neurodegenerative conditions, as well as in aging, may interfere with the G-protein coupled receptor signaling." ...

Brain's white matter -- More 'talkative' than once thought

...sing, causing nerve cells to die and creating such neurodegenerative conditions as multiple sclerosis. Bergles speculates that this white matter activity his team discovered may help “naked?nerve cells signal nearby OPCs and say “cover me with myelin because we need to replace another cell that has been damaged.?...

Newborn neurons like to hang with the 'in' crowd

...neuronal stem cells can replace damaged neurons in neurodegenerative diseases such as Alzheimer's or Parkinson's disease you have to ensure that these cells make proper connections, form functional synapses and integrate into the rest of the brain," says postdoctoral fellow Nicolas Toni, Ph.D., who headed the current ...

Scientists identify prion's infectious secret

Researchers have known for decades that certain neurodegenerative diseases, such as mad cow disease or its human equivalent, Cruetzfeldt-Jakob disease, result from a kind of infectious protein called a prion. Remarkably, in recent years researchers also have discovered non-pathogenic prions that play beneficial rol...

Studies force new view on biology of flavonoids

..., and protection against heart disease, cancer and neurodegenerative disease, Frei said. ...

Researchers develop marker that identifies energy-producing centers in nerve cells

...vel the mysteries of some of the most debilitating neurodegenerative diseases. The study's senior author, Tibor Kristian, Ph.D., an assistant professor in the Department of Anesthesiology at the University of Maryland School of Medicine, says there are animal models for several of these diseases including Parkinson's,...

3 proteins may play important role in nerve-cell repair

...ng stroke, brain and spinal cord injuries and also neurodegenerative diseases," says principal investigator Yoshinaga Saeki of the Ohio State University Medical Center. The study is published in the April 6 issue of the Journal of Biological Chemistry. Increased amounts of the proteins were associated with a s...

Stem cells act through multiple mechanisms to benefit mice with neurodegenerative disease

...-concept, a mouse model of a representative lethal neurodegenerative disease. Next, they used mouse neural stem cells (...but which is often used to model an array of adult neurodegenerative diseases such as Parkinson's, ALS, Alzheimer's - particularly those with a genetic component. The mo...

Smell may outlast other senses

...edications and changes associated with a number of neurodegenerative illnesses. Exposure to these factors typically increases with age.? Anticholesterol and blood pressure lowering medications were amongst the common drugs known to interfere with smell. Conditions such as Parkinson’s disease and Alzheimer’s disease ...

Scientists clone mice from adult skin stem cells

...e are many diseases, such as liver, pancreatic and neurodegenerative disorders where researchers are only able to obtai...nable scientists to generate neurons and study the neurodegenerative process. ...

Scripps research study reveals structural dynamics of single prion molecules

... to the discovery of novel therapeutic targets for neurodegenerative diseases. Intriguingly, certain prions and amyloids can play beneficial roles. The subject of the new study, Sup35, enables protein-based inheritance in yeast. When this prion protein misfolds, it converts into self-perpetuating amyloid fibrils, thu...

Protein sensor for fatty acid buildup in mitochondria

...ecause mutations in this enzyme cause an inherited neurodegenerative disease. A report on the discovery appears in the online pre-publication issue of Proceedings of the National Academy of Sciences (PNAS). "The results of this study show how and where a critical biochemical pathway for fatty acid breakdown is cont...

Proteins important in Alzheimer's, Parkinson's disease travel in the slow lane

...of axonal transport is important for studying many neurodegenerative diseases. The study appeared in the Journal of Neu...ce. Axonal transport often breaks down and many neurodegenerative diseases are characterized by defects in this process. Of particular interest is a group of transpor...

Researchers hot on the trail of brain cell degeneration

...test issue of Nature Neuroscience. In a number of neurodegenerative diseases, neurons in the brain are over-stimulated...ising findings add an entire pathway to the map of neurodegenerative signalling processes," says Courtney. "This area of investigation could therefore offer novel therap...

Strawberry daiquiris -- the extra-healthy cocktail?

... the prevention of diseases ranging from cancer to neurodegenerative disorders. They work by helping to mop up damaging free radicals produced naturally during a person’s normal metabolism. Those who aren’t keen on strawberry daiquiris might be relieved to know that the scientists found similar results with blackb...

Cancer researchers add spice to research against rare neuromuscular disease

...compound that shows promise against a debilitating neurodegenerative condition known as Kennedy's disease, which is cau...se is bit like Huntington's disease, a more common neurodegenerative disease that is inherited, fatal, and unyielding in its progression. Both are caused by an abnormal ...

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