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Tag: "neurodegeneration" at biology news

Study ties 'new' cell-death mechanism to developmental and degenerative brain disorders

...r accumulation and aggregation in the brain. "The neurodegeneration field has been dominated by the hypothesis of misf...been lacking," Pulst said. "This is the first time neurodegeneration has been directly linked to potassium channel mutations." In the Nature Genetics article, the rese...

Brain's own cannabis compound protects against inflammation

...ndocannabinoid system during neuroinflammation and neurodegeneration might open new avenues of therapeutic interventions in the future." ...

Parkinson's disease mechanism discovered

...o knew that accumulation of alpha-synuclein caused neurodegeneration in animal models of Parkinson's disease, but little was known about alpha-synuclein's normal cellular function or how it contributed to disease. One major problem facing researchers, Lindquist said, was that alpha-synuclein accumulation causes a rang...

'Sticky' mice lead to discovery of new cause of neurodegenerative disease

...al defect in protein synthesis could be behind the neurodegeneration they had observed in sticky mice. "There were a lot of candidate genes in the chromosomal region containing the sti mutation," she said, "and this gene was actually the last candidate gene we investigated. It seemed to us that a mutation in a gene...

Natural vitamin E tocotrienol reaches blood at protective levels

...n that needed to completely prevent stroke-related neurodegeneration as determined by earlier research. Conventional wisdom has suggested that TCT, if eaten, cannot be carried to organs because the protein known as tocopherol transfer protein (TTP), which delivers TCP throughout the body, doesn't transport TCT very...

New compound reduces stroke damage

...ion specific FKBP38 inhibitors in the treatment of neurodegeneration following stroke and a number of other diseases. ...

Insulin receptor stops progression of Alzheimer's disease

...n responses has been shown to halt or diminish the neurodegeneration of Alzheimer's disease, providing evidence that th...ptor (PPAR) agonists prevent several components of neurodegeneration and preserve learning and memory in rats with induced Alzheimer's disease (AD). They found that an a...

Protein sensor for fatty acid buildup in mitochondria

...n the PANK2 gene that give rise to PanK-associated neurodegeneration (PKAN), an inherited disease in which patients have intellectual impairment and difficulty in walking and speaking. "The new understanding of PanK2 activity and its location in the cell suggests a potential treatment strategy for PKAN," said Robe...

Penn researchers link cell's protein recycling systems

...that whenever we knocked the lysosome system down, neurodegeneration always got worse,” says Taylor. “Then when we acti...stem by feeding the flies a drug called rapamycin, neurodegeneration was prevented.” The accumulated misfolded proteins were cleared out by the lysosome system. “Then we...

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