Scientists find missing enzyme for tuberculosis iron scavenging pathway
...ombined with careful analysis of the sequence, its neighbors in the genome, and the fact that its gene was also regulated by iron, was that Rv1347c was almost certainly a "missing enzyme" from the pathway for biosynthesis of the iron scavenging agent mycobactin," recalls Dr. Baker. "Mycobactin is a small mole...Critical role in programmed cell death identified
...afeguard, to ensure that neurons talk to the right neighbors and make the right connections." Also, if cells do not die on schedule, unregulated growth can lead to tumors and other complications. "Mammalian studies that have implicated mitochondrial fragmentation in cell death have been done under rather arti...Stanford gut check shows diversity of intestinal ecosystem
...were novel, meaning that they had no genetic close neighbors in the existing databases that store sequence information about all known species. "We thought we would find new ones, but it was a bit surprising to see such a large percentage that had remained unidentified," said Eckburg. "Despite this large effo...Bioinformatics reveals new gene regulation system
... you are looking in one genome, many genes will be neighbors by coincidence," Gelfand noted. "But if two genes are neighbors in many diverse genomes, then they are likely to be related." Indeed, the Nrd genes and the transcri...Say what? Bacterial conversation stoppers
...ck another kind of bacteria from counting how many neighbors they have and, in turn, properly controlling its behavior." "This study moves us closer to really understanding how these interactions happen in nature," Bassler said. "Bacteria can communicate between species, and they have evolved mechanisms to in...'Sinkers' provide missing piece in deep-sea puzzle
...he surface, most deep-sea animals either eat their neighbors or feed on material (detritus) that drifts down from above. For decades oceanographers have used funnel-like collectors called sediment traps to measure how much food sinks down to the seafloor in the form of detritus. They have also estimated the am...Computers close in on protein structure prediction
...in its characteristic shape by the environment and neighbors they prefer. Then the computer randomly twists, loops, and bends each amino acid sequence into 100,000 different shapes based on the preferred location of the amino acids. Some amino acids tend to dive toward the watery world of the protein surface ...New study to explore cellular circuitry
...unction of unknown cellular players based on their neighbors and associates," said Eric M. Phizicky, Ph.D., professor of Biochemistry and Biophysics at the medical center. "That puts us within reach of a completed diagram and the ability to re-wire cells in the treatment of disease." Medical Center Tapped ...Why we give: New study finds evidence of generosity among our early human ancestors
...ho cannot produce much food, close kin, and nearby neighbors sometimes receive more than they give." ...When the going gets tough, slime molds start synthesizing
... up, Dictyostelium amebas band together with their neighbors and form a multi-cellular tower designed to save the children. In a forthcoming study in Nature Chemical Biology, investigators at the Salk Institute for Biological Studies and the Medical Research Council of Molecular Biology (MRC) in Cambridge, E...Two-faced protein can stop metastasis or promote it, researchers say
...erin is lost in a cell, it can break free from its neighbors and travel to settle elsewhere," he says. "This means that E-cadherin normally helps suppress invasion." But researchers have noted that the p120 catenin protein seems mysteriously two-faced: while it normally strengthens cell-cell bonding, in some ...Cocaine high caused by interference in neuronal receiving stations
...l Press. Neurons trigger nerve impulses in their neighbors by launching bursts of chemicals called neurotransmitters at them. The neurotransmitters activate protein receptors on the receiving neurons, which induce the nerve impulses in the receiving cell. These receptors also adjust themselves in complex way...Why doesn't the immune system attack the small intestine?
...ndritic cells display the antigens of their normal neighbors in a way that puts the immune system "at ease." By reading those antigens without being on alert, the immune system's T cells learn that such cells are off-limits to attack. For years, scientists have wondered whether the same mechanism is at work...New technologies coming too fast for Indian farmers
...tal testing, they were just using it because their neighbors were," Stone says. "There has been a breakdown in the process of farmers evaluating new seed technologies." 'De-skilling' While Bt seed exacerbates the problem by creating yet another option, the farming troubles predate its introduction. I...Parasites' impact goes beyond host to affect ecosystem
... that you might have more to eat if plenty of your neighbors are infected. The research, published in this week’s Proceedings of the National Academy of Sciences Early Edition ( http://www.pnas.org/papbyrecent.shtml ), suggests that parasites can not only substantially affect their hosts ?altering their growt......ly what that is," Lancaster said. "Orange-throated neighbors may indicate a trend in the frequency of orange-th...e wild that year, so the females exposed to orange neighbors and yellow sires in the experiments had the most fit progeny," Lancaster said. "But under different ...