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Tag: "nanoparticle" at biology news

Electric jolt triggers release of biomolecules, nanoparticles

...cisco. "You can think of the useful biomolecule or nanoparticle as a balloon tethered to a surface," he said. "We use an electrical pulse to cut the tether, and it floats away." This method could be used to control the release of drug molecules; nanoparticles; biopolymers such as peptides, proteins and DNA; and...

U-M researchers use nanoparticles to target brain cancer

... cause damage to healthy tissue. In our study, the nanoparticle becomes a vehicle to deliver the drug directly to ...le rats treated with Photofrin incorporated into a nanoparticle survived an average of 33 days. Forty percent of the rats remained disease-free six months after tre...

Nanoparticle assembly enters the fast lane

The speed of nanoparticle assembly can be accelerated with the assistance of...ty of the system, focusing next on the size of the nanoparticle clusters. ...

Scientists design simple dipstick test for cocaine, other drugs

...ne or blood serum. The test is based upon DNA-gold nanoparticle technology, and can be packaged in user-friendly k...ow devices as platforms to separate aptamer-linked nanoparticle aggregates, Lu, postdoctoral researcher Juewen Liu and graduate student Debapriya Mazumdar created h...

Widely used iron nanoparticles exhibit toxic effects on neuronal cells

...owever, there are recent reports that this type of nanoparticle can be toxic in some cell types, and our discovery of their nano-toxicity in yet another type of cell suggests that these particles may not be as safe as we had once thought." In their studies, the UCSD researchers used PC12 cells, a line derived f...

Coated nanoparticles solve sticky drug-delivery problem

... "We thought that if we could coat a drug-delivery nanoparticle with a chemical that had these characteristics, it might not get stuck in the mucus barrier." To make their nanoparticles behave like viruses, the researchers coated them with polyethylene glycol, PEG, a non-toxic material commonly used in pharma...

Nanoparticles for delivery of prostate cancer treatment

...he efficacy and safety of using targeted liposomal nanoparticle vectors ?lipid-covered, gene delivery packets ?to ...epared for a clinical trial. "The advantage of nanoparticle vectors is that they do not reproduce, are not immunogenic, and are easier to produce than adenovira...

Nanoparticles can track cells deep within living organisms

...eatments using unique signatures from the ingested nanoparticle beacons. In an article that will appear in the June issue of the FASEB Journal, lead author Kathryn C. Partlow, a doctoral student in Wickline's lab, describes using perfluorocarbon nanoparticles to label endothelial progenitor cells taken from h...

Intravenous nanoparticle gene therapy shows activity in stage IV lung cancer

... patients via an intravenously administered lipid nanoparticle in a phase I clinical trial at The University of ...ncer cells but is absent in those cells. The FUS1 nanoparticle formulation was developed and tested in Roth's lab. It advanced to phase I clinical trial after a ...

Scientists create dual-modality microbeads to improve identification of disease biomarkers

... into the solution. You just have to make sure the nanoparticle surface is hydrophobic so that it interacts with the beads," said Sathe. The primary biomedical applications for this new technology will be to detect cancer and neurological diseases by identifying certain molecules present in human blood or urin...

Dual gene therapy suppresses lung cancer in preclinical test

...that is deficient in most human lung cancers. Each nanoparticle carried one of the two genes. The Cancer Resea...es more cells killed by apoptosis than either gene nanoparticle had individually. The research team then confirmed these findings in the mouse studies. The nanop...

Cancer tip -- Nanoparticles can damage DNA, increase cancer risk

...mined the genotoxicity of silica and C60 fullerene nanoparticle suspensions using the alkaline single-cell gel ele...ble stranded DNA. The team chose these particular nanoparticle types because they are commonly used commercially ?in electronics, textiles and sporting goods ?and ...

Rapid, Low-Cost DNA Testing

..., the fluorescently tagged probe adsorbs on a gold nanoparticle and its fluorescence is quenched. If the probe sequence is able to hybridize to the target, it will not adsorb on the gold and its fluorescence persists. The new method is simple and effective. It costs very little, and it's very quick. The mos...

Iowa State scientists demonstrate first use of nanotechnology to enter plant cells

...ly by Lin’s research group. It is a porous, silica nanoparticle system. Spherical in shape, the particles have arr...e to carry a large payload," Trewyn said. Lin’s nanoparticle has a unique "capping" strategy that seals the chemical goods inside. In previous studies, his group...

Researchers develop buckyballs to fight allergy

...a new biological function for a soccer ball-shaped nanoparticle called a buckyball – the ability to block allergic response, setting the stage for the development of new therapies for allergy. Allergic disease is the sixth leading cause of chronic disease in the United States, and while various treatments have b...

UCF nanoparticle offers promise for treating glaucoma

A unique nanoparticle made in a laboratory at the University of Central ...ss and affects millions of people worldwide. “The nanoparticle can safely get past the blood-brain barrier making it an effective non-toxic tool for drug delivery,...

In nature, proteins sweep up nanoparticles

...understand the mechanism by which proteins promote nanoparticle aggregation. They found that the presence of cysteine, an amino acid that is a building block to most proteins, yielded the most extensive and prolonged aggregation, with some blobs measuring ten microns in diameter. Their discovery could also ref...

Bacteria ferry nanoparticles into cells for early diagnosis, treatment

...nd Computer Engineering. "Because the bacteria and nanoparticle material can be selected from many choices, this is a delivery system that can be tailored to the characteristics of the receiving cells. It can deliver diagnostic or therapeutic cargo effectively for a wide range of needs." Harmless strains of ba...

Microbes at work cleaning up the environment

...searchers showed that the bacteria are causing the nanoparticle aggregation, thereby protecting themselves. When t...se it involves the bacteria excreting proteins for nanoparticle aggregation away from the cells,” said Peter Weber, one of the LLNL authors of the paper appearing i...

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