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Tag: "nanoparticle" at biology news

DNA Molecules Used To Assemble Nanoparticles

...r, more efficient way to produce a wide variety of nanoparticle drug delivery systems, using DNA molecules to bind... is notoriously difficult and time-consuming. The nanoparticle system used by Baker's lab is based on dendrimers, star-like synthetic polymers that can carry a vas...

Novel technology detects human DNA mutations

... of the versatility of our proprietary ClearReadTM nanoparticle technology," said William Moffitt, Nanosphere's President and CEO. "This study and the use of nanoparticles to dramatically increase sensitivity in our other proprietary applications -- such as bio-barcode for ultra sensitive detection of proteins --...

Tiny particles could solve billion-dollar problem

...rt base, pure palladium nanoparticles and a hybrid nanoparticle developed by Wong that consists of a gold nanoparticle covered with a thin coat of palladium atoms. As metal particles get progressively smaller, a higher...

Scientists develop new color-coded test for protein folding

...s color when a protein molecule attached to a gold nanoparticle folds or unfolds. The new technique, which works o...mplicated proteins," Zare said, noting that a gold nanoparticle sensor could turn out to be a quick and inexpensive way for doctors to identify antibodies and other...

Nanoscale Diagnostic Sets Sights on Alzheimer's

...en add a second ingredient that consists of a gold nanoparticle core surrounded by hundreds of identical DNA strands, which serve as hundreds of "bio-bar-codes" the researchers can detect at the end of the test. Ultimately, the gold-DNA particles and magnetic particles sandwich the biomarker targets. A magnet se...

Nanoparticles offer new hope for detection and treatment

...., professor of medicine, are co-inventors of this nanoparticle technology. The effectiveness of the nanoparticles...hat make it especially interesting as a target for nanoparticle therapy. Melanoma has a horizontal phase, when it spreads across the skin surface, and a vertical ph...

Nanoparticle Breast Cancer Drug Approved by FDA

...ineered using a proprietary process (protein-bound nanoparticle technology) to create tiny particles (nanoparticles 100th the size of a red blood cell) in which the active chemotherapeutic drug, paclitaxel, is bound to a naturally occurring protein called albumin. By using this nanotechnology, the active compone...

MIT engineers an anti-cancer smart bomb

... cells unscathed. MIT researchers have designed a nanoparticle to do just that. The dual-chamber, double-acting,...eding the tumor then collapse, trapping the loaded nanoparticle in the tumor, where it slowly releases the chemotherapy. The team tested this model in mice. The do...

Using nanoparticles, in vivo gene therapy activates brain stem cells

... and cell types. A key advantage of the UB team's nanoparticle is its surface functionality, which allows it to b...orescent marker gene, demonstrating the ability of nanoparticle technology to deliver effectively genes to specific types of cells in the brain. Using a new optica...

Breakthrough: Scientists create world's tiniest organic particles

...thods for fabricating transistors with the organic nanoparticle world," said Bruce Boucher, president of Liquidia. "It is truly a revolutionary discovery." ...

'Smart' nanoprobes light up disease

... called "quenching" that involves tethering a gold nanoparticle to the quantum dot to inhibit luminescence. The tether, a peptide sequence measuring only a few nanometers, or billionths of a meter, holds the gold close enough to prevent the quantum dot from giving off its light. In their test system, the Rice te...

NJIT study shows nanoparticles could damage plant life

A nanoparticle commonly used in industry could have a damaging ef...atts, is the nature of the interaction between the nanoparticle and the root of the seed. "What is the mechanism of the interaction between the particle and the roo...

Nanoparticles, nanoshells, nanotubes: How tiny specks may provide powerful tools against cancer

...by varying the size of the core and the shell. A nanoparticle combined with a hormone and cell-killing peptide i...d a molecular complex, combining LHRH with a 10 nm nanoparticle ?superparamagnetic ironoxide ?and a cell-killing peptide drug, Hecate. Leuschner and her co-worker...

Targeted drug delivery achieved with nanoparticle-aptamer bioconjugates

...eled model drug within them, in order to visualise nanoparticle uptake into target cells. The nanoparticles in question were designed for attachment to aptamers so that the binding properties of aptamers for targeting could be preserved. Additional design criteria consisted of the development of nanoparticles tha...

Researchers use 'trickery' to create immune response against melanoma

...eled model drug within them, in order to visualise nanoparticle uptake into target cells. The nanoparticles in question were designed for attachment to aptamers so that the binding properties of aptamers for targeting could be preserved. Additional design criteria consisted of the development of nanoparticles tha...

Cellular scale drug delivery from the inside out

... achieve external control, Lin is using iron-oxide nanoparticle caps which can be manipulated by a magnetic field. In a simple demonstration of the principle, Lin holds a refrigerator magnet up to a liquid-filled glass vial containing human cervical cancer cells grown in vitro that contain nanospheres capped with...

Gold nanoparticles could improve antisense cancer drugs

... strands of antisense DNA to the surface of a gold nanoparticle (forming an "antisense nanoparticle") the DNA beco...ore effectively than DNA that is not attached to a nanoparticle surface (as in commercial agents). When compared to antisense DNA complexed with commercial agents ...

Immune cell communication key to hunting viruses, Jefferson immunologists show

...lls. What they found surprised them. While the nanoparticle specifically bound to the surface of T-cells with receptors recognizing the viral-MHC complex, the control ?a biosensor that carried the same MHC protein with a different peptide not recognized by the T- cells ?unexpectedly also binded almost as st...

MIT nanoparticles may help detect, treat tumors

...o "self-assemble" or stick together. The resulting nanoparticle clumps are too big to get back out of the gaps. Further, the clumps have a stronger magnetic signal than do individual nanoparticles, allowing detection by MRI. "We inject nanoparticles that will self-assemble when they are exposed to proteases ins...

Researchers make nanosheets that mimic protein formation

...ty of practical applications from light-harvesting nanoparticle devices to new drugs which can act like proteins, ...ion from bright green to dark red depending on the nanoparticle size, are made from cadmium telluride crystals, a material used in solar cells. The sheets are about...

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