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Tag: "mutations" at biology news

Novel technology detects human DNA mutations

...ficity and sensitivity. One segment identifies any mutations in the DNA and the probe, a highly sensitive gold nanoparticle, creates a strong signal accurately indicating the presence of a specific target SNP. Proof of principle, reproducibility, and the robust, simple and rapid characteristics of this technol...

Neuronal 'traffic jam' marks early Alzheimer's disease

... to alter those neurons genetically by introducing mutations know to cause Alzheimer's disease in people, to then test for transport defects, and then study whether those defects produce pathology similar to that seen in Alzheimer's. One of the questions they will also ask is whether amyloid plaques poison the...

Researchers Uncover Key Step In Manufacture of Memory Protein

...rned that some human beings lack normal CPE due to mutations in the CPE gene. Future research may determine if the CPE mutation affects these individuals?long-term memory. ...

Research on Worms Yields Clues on Aging

...y movement.Scientists previously had found genetic mutations in C. elegans thataffect both the nervous system and life span. The researchers usedthese mutant worms to further pin down the mechanism by which theanticonvulsants increased longevity.The worms' mutated genes affect the function of sensory neurons t...

Mitochondrial DNA mutations play significant role in prostate cancer

...andfound a variety of mutations, including various mutations in the mtDNAcytochrome oxidase subunit (COI) gene....ples from patientsfound to be cancer free harbored mutations in this gene. In a controlsample of 1,019 individuals from the general population, 7.8 percenthad mu...

BRCA1 causes ovarian cancer through indirect, biochemical route

...xciting." Dubeau points out that women with BRCA1 mutations are also predisposed to cancers of the fallopian tubes, and that the mice with mutated BRCA1 genes in their granulosa cells developed tumors there as well. "This not only underscores the relevance of our mouse model to human cancer," Dubeau notes, "B...

Scientists discover the cellular roots of graying hair

...ay. It may be that people who grayprematurely have mutations that knock out Bcl2 activity, Fisher says.“This tells us there is a requirement for Bcl2 in normal hair folliclecycling,?adds Fisher. “So the question is: what in the hair follicleis signaling the stem cells that is absent when aging occurs and thest...

Fundamental Finding Yields Insight into Stem Cells, Cancer; Opens Door to Drug Discovery

...ay. It may be that people who grayprematurely have mutations that knock out Bcl2 activity, Fisher says.“This tells us there is a requirement for Bcl2 in normal hair folliclecycling,?adds Fisher. “So the question is: what in the hair follicleis signaling the stem cells that is absent when aging occurs and thest...

Weizmann Institute scientists develop a new approach for directing treatment to metastasized prostate cancer in the bones.

...ay. It may be that people who grayprematurely have mutations that knock out Bcl2 activity, Fisher says.“This tells us there is a requirement for Bcl2 in normal hair folliclecycling,?adds Fisher. “So the question is: what in the hair follicleis signaling the stem cells that is absent when aging occurs and thest...

First 'atlas' of key brain genes could speed research on cancer, neurological diseases

...n tumors andneurological diseases that result from mutations in these switch genes?called “transcription factors.?When these genes are altered, thegenes they control can go awry, causing abnormalities in thedevelopment or function of nerves and related structures.Although the gene regulators were pinpointed us...

Nanogen Issued Patent for Electronic Microarray With Memory

...s to detect infectious diseases, drug toxicity and mutations associated with cancer, cardiovascular and genetic diseases. The next generation instrument system, the NanoChip(R) 400, is expected to be available in 2005. Nanogen's subsidiary SynX offers a line of point-of-care diagnostic tests and is building ex...

Same mutation aided evolution in many fish species, Stanford study finds

...iend to laboratory researchers who have found that mutations in the same gene in mice cause altered hair patter...ased on the mouse work you'd predict we would find mutations in any of the three genes in sticklebacks," said Kingsley, who is also a Howard Hughes Medical Insti...

Researchers trace evolution to relatively simple genetic changes

...completely viable and healthy,' he said. "Eda gene mutations cause a disease in humans, but not in the fish. So this is the first time mutations have been found in this gene that are not associated with a clinical syndrome. Instead, they cause e...

Octopuses occasionally stroll around on two arms, UC Berkeley biologists report

...completely viable and healthy,' he said. "Eda gene mutations cause a disease in humans, but not in the fish. So this is the first time mutations have been found in this gene that are not associated with a clinical syndrome. Instead, they cause e...

UCLA scientists transform HIV into cancer-seeking missile

...to correct acquired and genetic diseases where the mutations exert their harmful effects on the body." Melanoma is a serious form of skin cancer. According to the American Cancer Society, an estimated 59,580 Americans will be diagnosed with melanoma in 2005, and about 7,770 people will die of the disease. ...

Breast Cancer May Be 'Uniquely Sensitive' To Inhibitors Of PI3K Pathway

...rant at multiple levels inbreast cancer, including mutations in PI3K itself or its many“downstream?players, such as PTEN, or AKT.“There is a lot of crosstalk between the PI3K pathway and otherpathways, a lot of feed-forward and feedback loops,?says Mills. “But Iand others believe there are central nodes betwee...

Genetic Variation Visualization - From EMBL

...rant at multiple levels inbreast cancer, including mutations in PI3K itself or its many“downstream?players, such as PTEN, or AKT.“There is a lot of crosstalk between the PI3K pathway and otherpathways, a lot of feed-forward and feedback loops,?says Mills. “But Iand others believe there are central nodes betwee...

Newly Discovered Compound Blocks Known Cancer-Causing Protein

...Ras is a normal genetic component of the cell, but mutations in the gene can cause it to become stuck in an "on" position, promoting uncontrolled cell growth. Mutations in Ras that permanently activate it have been found in half of all colon cancer and 90 percent of pancreatic cancers, among other cancers. Ca...

New Mixing Method for Microchip-Sized Labs

...rant at multiple levels inbreast cancer, including mutations in PI3K itself or its many“downstream?players, such as PTEN, or AKT.“There is a lot of crosstalk between the PI3K pathway and otherpathways, a lot of feed-forward and feedback loops,?says Mills. “But Iand others believe there are central nodes betwee...

Plants defy Mendel's inheritance laws, may prompt textbook changes

... already in plants and animals in order to correct mutations that cause diseases and abnormal growth. Though further research is required to learn how this form of inheritance happens and how it can help improve plants or animals through gene therapy, Pruitt said the discovery has opened an important new line...

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