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Tag: "mutation" at biology news

A little telomerase isn't enough

...re that inherited disease accompanies an inherited mutation in one or more genes. In the case of the genetical...s Greider. "If you were to search for the genetic mutation behind this mouse's disease, you wouldn't find it -- there isn't one," says Greider. "These mice dev...

MicroRNA gene that regulates lifespan found by Yale scientists

...th of these genes. Animals with a loss-of-function mutation in lin-4 had a lifespan that was significantly sho... lifespan. They also found that a loss–of-function mutation in lin-14, the target of lin-4, caused the opposite effect -- a 31 percent longer lifespan. Accordi...

Cornell finds natural selection in humans

... number of children left by those that carried the mutation -- can by chance become quite common in the population. The authors also found a correlation between genes predicted to be under negative selection and genes implicated in certain hereditary diseases. For example, among the genes the researchers ...

Study provides insight into cellular defenses against genetic mutation

...sease. One frequently occurring, damaging class of mutation is the inclusion of premature "stop reading" signals (stop codons) within mRNAs. Called "frameshift" or "nonsense" mutations, they order the genetic process to stop reading part way through the instructions, resulting in the building of incomplete pr...

Gene therapy reverses genetic mutation responsible for heart failure in muscular dystrophy

...r reversing the damage to the heart caused by this mutation and extending lifespan," explained Dr. Tong Zhu, M.D., Ph.D., a research associate in the department of orthopaedic surgery and the first author of the study. "In fact, if this study holds up in human clinical trials, it may have profound implication...

Scientists unpick genetics of first 15 minutes of life

...s in sexually reproducing animals. The absence or mutation of this gene in the maternal (mother's) genome exp...ame mutant and identified what is known as a point mutation in the HIRA gene ?showing that HIRA is the gene responsible for chaperoning the assembly of the sper...

Picky female frogs drive evolution of new species in less than 8,000 years

...e because of natural selection or genetic drift or mutation or some combination of those three, and reproductive isolation is just some glorious accident that arises from that," Moritz said. "We do have very compelling evidence. We have addressed various lines of evidence and conclude that there has been rein...

Biologists Crack Genetic Code for Specialized Spider Silk

...affected has a 50 percent chance of inheriting the mutation and being predisposed to IgA deficiency and CVID. “A test for TACI defects would enable the diagnosis of more children and their relatives with these immune deficiencies,?says Dr. Geha, senior author of the study and the James Gamble Professor of Pe...

Agreement will speed research on microbicides for women

...affected has a 50 percent chance of inheriting the mutation and being predisposed to IgA deficiency and CVID. “A test for TACI defects would enable the diagnosis of more children and their relatives with these immune deficiencies,?says Dr. Geha, senior author of the study and the James Gamble Professor of Pe...

Defective Gene Linked to Two Inherited Immune Deficiencies

...affected has a 50 percent chance of inheriting the mutation and being predisposed to IgA deficiency and CVID. “A test for TACI defects would enable the diagnosis of more children and their relatives with these immune deficiencies,?says Dr. Geha, senior author of the study and the James Gamble Professor of Pe...

MBL researchers probe how an ancient microbe thrives and evolves without sex

...ten go unchecked and are believed to contribute to mutation (and eventually extinction) in species that reproduce asexually. To learn more about the bdelloid rotifers' unique ability to evolve without sex, Arkhipova and Meselson studied portions of different bdelloid rotifer genomes and surveyed the diversit...

The ecological effects of the Chernobyl disaster

... how the environment has responded -- from genetic mutation rates, to plant and animal communities, to nutrient cycling. Sergey Gaschak (International Radioecology Laboratory, Ukraine) will open the session with his presentation, "Determinants of levels of 90Sr and 137Cs in birds in Chernobyl." Studying 228 ...

Immune system has evolved to prevent autoimmune disease

...tach themselves to proteins in a healthy cell. The mutation response method employed by our adaptive immune system seems keyed to this number, producing antibodies that are statistically likely to mistakenly bond with healthy proteins slightly less than one in a trillion times, meaning that on average, they r...

MWG Biotech expands siMAX?siRNA portfolio with new scales, lengths and design tools

...o a sexually active adult. It is the first genetic mutation found to cause early maturation in fruit flies, according to a new study in the Friday June 3 issue of the journal Cell. The flies are abnormally small and die as they enter adulthood, sometimes when their heads fail to emerge from their bodies. "We...

Scientists find a maturity gene in fly

...o a sexually active adult. It is the first genetic mutation found to cause early maturation in fruit flies, according to a new study in the Friday June 3 issue of the journal Cell. The flies are abnormally small and die as they enter adulthood, sometimes when their heads fail to emerge from their bodies. "We...

New gene scanning technology marks a major advance in disease research

...pact on healthcare in the future. One of two gene mutation scanning techniques devised by Professor Day and his team in the Human Genetics Division of the University's School of Medicine has been successfully applied to search for rare genetic mutations in the population at large. Their method, called meltM...

Learning how SARS spikes its quarry

...n particular, he said, the new structure shows how mutation at one of the two sites can enable the animal SARS virus to infect humans, but by itself this mutation does not appear to allow subsequent human-to-human transmission. "The observation is that a dramat...

Stressed cells spark DNA repair missteps and speed evolution

... of Medicine, first published her finding that the mutation rate increased in bacteria stressed by starvation,...xperiments proved that this mechanism of increased mutation at sites of DNA repair occurs only in the cells under stress. "Even if you get a break in a cell, it...

Protein amplification in melanoma is possible drug target

A newly discovered gene mutation may account for many cases of immune deficiency, i...ons are dominant, people with even one copy of the mutation will be unable to mount a strong antibody response. "A test for TACI would allow for diagnosis of m...

Gene for immune deficiency syndromes found

A newly discovered gene mutation may account for many cases of immune deficiency, i...ons are dominant, people with even one copy of the mutation will be unable to mount a strong antibody response. "A test for TACI would allow for diagnosis of m...

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