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Tag: "mutant" at biology news

Discovery suggests why stem cells run through stop signs

...ies' ovaries and studied how many egg chambers the mutant stem cells produced as compared to normal stem cells. The production rate in the mutant cells fell over the course of 12 days, and the researchers concluded it was because the mutant stem ...

Sleeping beauty plays a significant role in identifying cancer genes

...ods do not -- such as the specific combinations of mutant genes that can work together to cause cancer. "With this information, we will understand the development of tumors at the genetic level in much finer detail," he said. "This is important because no single kind of cancer is going to be cured by one dr...

UCR biochemist goes to Washington with high-protein corn

... can easily be applied to sweet corn, a sugar-rich mutant strain of regular corn. ...

Two designer drugs hit same lung cancer target, but only one is effective

... drug cetuximab (Erbitux) had little effect on the mutant signal, evidently because it strikes at a differen...lung cancer (NSCLC), the overactivity stems from a mutant EGFR protein: those patients tend to have a better outlook, and Iressa and Tarceva are particularly ...

Opiate cocktail may spare cells from morphine's dark side

... and indeed past work from Whistler indicated that mutant versions of the receptor that are more readily internalized were associated with reduced levels of morphine tolerance in mice. In the new work, the researchers sought a more clinically practical approach to facilitating MOP-receptor internalization ...

Gaining ground in the race against antibiotic resistance

...her antibiotics, as well," said Vila. In fact, the mutant enzyme inactivated seven other cephalosporins as efficiently as or better than the original enzyme. "So it hasn't lost anything, and the outcome is that the bacteria has increased its range of resistance. This is a huge concern in the clinic." To da...

Virus uses tiny RNA to evade the immune system

...lls were more likely to kill cells infected with a mutant virus that cannot make the microRNA than the normal virus. Thus, microRNA-induced reductions in T antigen expression promote escape from antiviral T cells without affecting virus growth. "Viruses can use the host RNA inference machinery, which is of...

miRNAs and musculature

...ally death of Dmir-1 KO larvae. Analysis of the mutant larvae after feeding reveals disrupted somatic musculature, strongly suggesting a role for Dmir-1 in the maintenance of muscle integrity and identity in times of stress induced by growth. Dr. Sokol proposes that "Mir-1 could function generally to ma...

Old drug shows new promise for Huntington's Disease

...e or effective treatment. A person who carries the mutant Huntington's gene may pass it on unknowingly becau...n's gene causes the production of a toxic protein, mutant huntingtin, in neurons (brain cells). Eventually the protein kills the neurons, causing the disease'...

Immune system has evolved to prevent autoimmune disease

...effective, as it rapidly creates and mass produces mutant white blood cells called B cells that make only these antibodies." Deem said prior research has identified a number of alternate strategies the immune system could use to reduce the time needed to create an effective B cell. In addition, these metho...

Tiny roundworm's telomeres help scientists to tease apart different types of aging

...pan. On the other hand, long-lived and short-lived mutant worms could have them either way without any effect on their lifespan. When Raices monitored telomere length over the full lifespan of worms and under stress, a situation reported recently at another laboratory to shorten telomeres in humans, she fou...

Newly recognized gene mutation may reduce seeds, resurrect plants

...found the gene while studying a unique surface wax mutant of Arabidopsis, a common laboratory research plant...verlaying leaves and stems. The abnormal plant, a mutant of RST1, had short, rounded leaves that turned purple during development, and then before flowering,...

Scientists unpick genetics of first 15 minutes of life

...his process occurs, the researchers used a type of mutant fruit fly, known to biologists as a s�same mutant,...he scientists found that the pro-nucleus in s�same mutant is wound into a tight ball that could not interact with its female counterpart, the egg pro-nucleus....

New study to explore cellular circuitry

...entity of the proteins that can re-wire particular mutant cells will also help researchers complete the wiring diagram. "A completed yeast cell diagram would help us build one for humans," said Elizabeth J. Grayhack, Ph.D., a research associate professor of Biochemistry and Biophysics at the medical cent...

Zebrafish may hold key to improved cancer research

...nter archives, propagates and distributes the many mutant lines of zebrafish now developed worldwide to aid research on specific genes in development and disease. This research has proven that the mechanism of cancer prevention in fish is remarkably similar to that of humans, including the genes involved. ...

Sickle cell disease corrected in human models using stem cell-based gene therapy

...rfering RNA specific for beta S-globin, the globin mutant chain that causes sickle cell disease. "An innovative and sophisticated approach was needed to genetically engineer hematopoietic stem cells using a practical and clinically applicable process. The transferred gene must not disrupt the cells' norma...

Plant gene related to cancer treatment may foster new oncology drugs

...rticle. Named for the pin-shaped appearance of the mutant originally used to identify the gene that directs the activities of PIN1, these proteins are members of the major protein family, called facilators, that aid processes such as hormone transport. Recent evidence suggests that teamwork between PGP and...

NIAID researchers show how promising TB drug works

...-824-resistant bacteria, the team identified those mutant strains with FGD1 and F420. The investigators reas...tional genetic techniques for comparing normal and mutant strains of M. tb failed, so the team turned to a specially modified microarray-based technique, call...

Bacteria which sense the Earth's magnetic field

...ng the relevant gene from the genome. In this way, mutant bacteria were created which were lacking the MamJ ...ular size, the magnetic crystals clump together in mutant bacteria. The scientists speculate that the MamJ protein develops, on one hand, on the surface of t...

Gene controls whether fear is a factor

...paired ability to learn fear. In other tests, the mutant mice also showed less instinctive fear of open spaces, venturing out into environments they would usually avoid naturally, Shumyatsky said. Mice lacking stathmin continued to perform normally on a water maze test, an indication that spatial learning ...

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