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Tag: "mutant" at biology news

UI researcher studies deafness in fruit flies, humans

...nsible for hearing in fruit flies. Whether or not mutant fruit flies can hear the fruit fly love song (actu...the normal flies to those generated by myosin VIIA mutant flies, they showed that the myosin VIIA gene is essential for hearing in flies, as it is in humans. ...

Scientists inhibit cancer gene

...e University of Utah discovered a way to inhibit a mutant gene found in up to 30 percent of human tumors. C...e a highly "expressed" -- meaning highly active -- mutant of the Ras oncogene. Such mice were first developed years ago. Prior studies had demonstrated that t...

Mosaic mouse technique offers a powerful new tool to study diseases and genetics

...DM acts more like a scalpel, creating a handful of mutant cells in an otherwise normal animal. Mosaic mice ... that allows researchers to control when and where mutant cells are generated in the fly's body. However, scientists have had a much more difficult time desig...

Researcher gets NSF grant to create mutant maize lines

...e genome. Once scientists have identified a maize mutant from the online library, they will be able to order kernels with that specific knockout gene. Researchers can then grow plants to identify the function of the gene they are interested in. The maize kernels will be donated to the U.S. Department of A...

New insights into how Huntington's disease attacks the brain

...olds that Huntington's disease (HD) is caused by a mutant protein that arises within brain cells and kills t...e study reveals the first strong evidence that the mutant protein also elicits toxic interactions from neighboring cells to provoke the fatal brain disorder. ...

Scientists find microRNAs regulate plant development

...t several other institutions noticed that the ago1 mutant failed to form adventitious roots - a type of root...not. Dr. Bellini and her colleagues found that the mutant plants over-accumulate ARF17 mRNA within the hypocotyl, pointing to ARF17 as a major regulator of ad...

Scientists find that protein controls aging by controlling insulin

...human life. Their previous studies have shown that mutant mice lacking the Klotho gene appear normal until a...the current study, they created a second strain of mutant mice in which the Klotho gene generated more of the protein than in normal mice. Those mice lived be...

Pinpointing a culprit molecule in Alzheimer's disease

..., such mice are genetically altered to overproduce mutant human amyloid precursor protein (APP). It is this ...archers crossed the Ab42 mice with those producing mutant APP, they saw a massive increase in amyloid deposition that was more than the additive effect of the...

Most common lung cancers may begin in newly discovered cells

...y a few cells. The mouse is known as a conditional mutant strain. In this case, the mouse inhales a small am...Clara or alveolar cells. In tissue cultures of the mutant mouse lung cells, the activated oncogene only triggered growth of the BASCs, not of the more special...

Bacteria are key to 'green' plastics, drugs

...he centerpiece of Rice's succinate technology is a mutant form of E. coli that makes succinate as it's only metabolic byproduct. The bug contains more than a half-dozen genetic modifications. It was created over the past four years by the research groups of Bennett and collaborator Ka-Yiu San, the E.D. Butc...

Nicotine triggers the same brain reward circuitry as opiates

...e opiate receptors, blocked CREB activation. Also, mutant mouse strains lacking the opioid receptor did not ...locked this conditioned increase in CREB, and that mutant mice lacking CREB or pretreated with naloxone did not show any reward response to nicotine. However...

A new molecule discovered in the battle between plants and disease

...g AtPep1 to jasmonate-deficient fad3-2 fad7-2 fad8 mutant plants did not induce the proAtPep1, PDF1.2 or PR-1 genes, indicating that AtPep1 signaling involves the octadecanoid pathway. AtPep1 induction of defense genes in excised Arabidopsis leaves was inhibited by DPI, implicating the generation of H2O2 in...

Gap-climbing fruit flies reveal components of goal-driven behaviors

.... In their genetic analysis, the researchers found mutant flies with defects specifically in deciding whether to cross, another group of mutants performing the correct motor program at a wrong position, and still another group of mutants performing climbing actions at the correct position but without one of...

Compound from Chinese medicine shows promise in head and neck cancer

...f cancer. They found cisplatin killed cells with a mutant form of the protein p53, but cells with normal p53...macology, overexpressed Bcl-xL in tumor cells with mutant or non-mutant p53. Only cells with non-mutant p53 and high Bcl-xL became resistant to cisplatin. Bau...

Mass production of human papillomavirus could lead to gains against cervical cancer

...ions at will in the virus genome and recover these mutant genomes in infectious virus particles, to study their effects on the virus's ability to infect its target cell," said Ahlquist. Importantly, said Ahlquist, the system successfully produces multiple types of HPV. "We found no specificity of this tech...

Elderly mice yield clues to the process of growing old

...mas A. Prolla describes a series of experiments in mutant and normal mice that peel away some of the root secrets of mammalian aging. Growing old, according to the new study, occurs, in part, as mutations build up in the DNA of energy-generating mitochondria, triggering the death of critical cells that lea...

Engineered skin offers clues to melanoma development

...zed. The researchers began by introducing several mutant genes commonly found in human melanomas. These inc...ith the progression of many cancers. None of these mutant genes, when introduced individually or in combination, led to cancerous growth. But when a mutant fo...

Ibruprofen and other commonly used painkillers for treating inflammation may increase the risk of heart attack

...zed. The researchers began by introducing several mutant genes commonly found in human melanomas. These inc...ith the progression of many cancers. None of these mutant genes, when introduced individually or in combination, led to cancerous growth. But when a mutant fo...

Researchers use RNAi libraries to identify regulators of apoptosis and chemoresistance

...zed. The researchers began by introducing several mutant genes commonly found in human melanomas. These inc...ith the progression of many cancers. None of these mutant genes, when introduced individually or in combination, led to cancerous growth. But when a mutant fo...

Treatments have same target, different responses for lung cancer patients with genetic mutation

...ients with non�small-cell lung cancer (NSCLC) have mutant versions of the epidermal growth factor receptor (...rowth and increasing apoptosis in NSCLC cells with mutant EGFR. The authors note that because these studies were carried out in cell lines, and not in human...

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