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Tag: "mutant" at biology news

Silence the gene, save the cell: RNA interference as promising therapy for ALS

...bischer notes. Recent research also indicates that mutant SOD1 gene expression in neighboring glial cells is...lleagues used RNA interference to reduce levels of mutant SOD1 protein in the spinal cords of transgenic ALS mice (mice bred to express the human SOD1 gene). ...

Researchers report new pro-inflammatory role for anti-inflammatory enzyme

...in vivo using mice that do not produce eNOS. These mutant mice had a marked reduction in iNOS production in response to bacterial endotoxin, as well as lower plasma levels of NO2- and NO3- and less mortality than normal mice. The scientists also showed that endotoxin activates eNOS in macrophages and that t...

Discovery may lead to better Candidiasis drug

...et-binding protein on Candida albicans by creating mutant strains of the fungus without the target and exposing the mutants to histatin. Results showed that histatin was significantly less active when the suspect target was missing. Further research indicated that histatin binding to the target protein kil...

A puzzle piece found in unraveling the wiring of the brain

...nal Neuron. "We were surprised to find an exocyst mutant having such specific defects," said Bellen, professor of molecular and human genetics at BCM. "The cell biological basis of brain wiring is largely unknown. We are happy to have a new handle on an old problem." Using sophisticated genetics applied t...

New tumor-suppressor gene discovered

.... "When we introduced the human mats gene into the mutant fly's body, we found it was able to perform the sa...s. He used genetic-mapping techniques to study the mutant fly's chromosomes and identified a short segment of DNA on which a mutant gene was most likely to oc...

Study reveals candidate targets for anti-retroviral therapeutics

...d biochemistry, screened a collection of over 4457 mutant yeast strains representing most of the known genes in yeast. They then solicited the help of computer scientist Pierre Baldi, also at the University of California, to focus on gene functions likely to be particularly significant in the Ty3 lifecycle....

Secret of smallpox's success may lead to bioterror cure

...e past 15 years, Jacobs has developed a variety of mutant vaccinia viruses that lack the camouflage gene, an...and then is vaccinated with a very low dose of the mutant virus ?only 100 virus particles ?the mouse gets sick but eventually recovers. The more mutant virus ...

Cellular Defects in Premature Aging Disease are Reversible

.... In addition, they found that introduction of the mutant protein into healthy human cells was sufficient to...utic effect, we needed to completely eliminate the mutant protein," said Scaffidi. The NCI researchers designed a chemically stable DNA oligonucleotide ?a sh...

Supercomputers to focus brains on AIDS dilemma

...e in these discoveries. However, in recent years, mutant strains of HIV have shown increasing resistance to many of these formerly effective drugs, raising the specter of reduced life-spans and wider spread of HIV. "Fortunately, in this ongoing battle, computational and structural biology may once again b...

Disease progression model of pancreatic cancer developed by Penn researchers

...gy, and colleagues, engineered mice to express two mutant genes commonly associated with pancreatic cancer: ...ll. The disease that develops in the Kras and p53 mutant mouse model demonstrates distinct similarities to human pancreatic cancer at multiple levels. "In te...

Master gene controls healing of skin in fruit flies and mammals

...o develop properly. Confirming her suspicions, the mutant embryos turned out to be much more permeable to a ...The group also showed that the genes active in the mutant flies' lesions were activated in normal flies in cells surrounding a wound created with a sterile ne...

Unchecked DNA replication drives earliest steps toward cancer

...ror-generating process leads to an accumulation of mutant genes in the cell and, eventually, cancer. A report on the new findings appears in the April 14 issue of Nature and is featured on the journal's cover. "Cancer progression is driven by these mutations," explains Thanos D. Halazonetis, D.D.S., Ph.D....

Discovery clarifies role of peptide in biological clock

...study that the percentage of rhythmic cells in the mutant SCN was very low, and he believes these rhythmic neurons are specialized circadian pacemakers. "We suspect that at least some of the pace making cells in the SCN are VIP cells, and one of the things we'll try to do next is confirm this. We will also...

To Stop Evolution: New Way Of Fighting Antibiotic Resistance Demonstrated By Scripps Scientists

...y to thank for this. But in the last few decades, mutant strains of several types of bacteria with the ability to resist antibiotics have emerged, including those that cause TB, pneumonia, cholera, typhoid, salmonella, and staphylococcal dysentery. These diseases are coming back resistant to the antibiotic...

Chemical Engineer Kao Explores Antibiotic Synthesis With DNA Chips

... up drug development. "Companies have proprietary mutant [bacterial] strains that have been worked on for m...or the antibiotic-producing genes. The result? The mutant produces erythromycin for five days. The nonmutant produces it for only one. If the specific mutatio...

Scientists identify genes responsible for 'black rot' disease in vegetables

...rchers then screened an Xcc transposon insertional mutant library in its host plant (cabbage). They screened a total of 16,512 Xcc mutants on individual cabbage plants and, of these, 172 proved to be non-pathogenic. Upon further characterization of the 172 non-pathogenic mutants, the researchers came up wit...

U. Iowa researchers improve Huntington's disease symptoms in mice

...ing protein and clear out the damage caused by the mutant protein. The genetically engineered or transgenic...in Davidson's current study would silence both the mutant and the normal gene. So, an important question that still needs to be addressed is whether adult neu...

Researchers pioneer new gene therapy technique using natural repair process

...lthy cells grow and divide preferentially over the mutant ones." Previous gene therapy attempts for SCID ha... instance, the correct IL-2R gene was delivered to mutant cells of SCID children by a disabled virus, but some subsequently developed leukemia because the vir...

Researchers Identify Cause of Early Bird Sleep Disorder

...ide-eyed much before dawn, can blame a newly-found mutant gene for their sleep troubles, Howard Hughes Medic...ene," Ptacek explained. It's not yet clear how the mutant gene works to shift people's sleep time, their circadian rhythm, he added. But follow-on experiments...

Gene silencing technique offers new strategy for treating, curing disease

... about ways to correct genetic disease by changing mutant gene sequences back to normal," Dr. Corey said. "Those types of things now look a lot more feasible." Genes are segments of DNA housed in the chromosomes in the nucleus of every cell. Genes carry instructions for making proteins, which in turn carry...

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