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Tag: "mutant" at biology news

A gene's first 'kiss' sets off that affair known as puberty

...and Journal of Medicine article that described the mutant GPR54 gene. ...

Novel technology detects human DNA mutations

...o determine if they are homozygous (i.e., both are mutant or normal) or heterozygous (i.e., one is mutant, one is normal) ?the most critical step in correlating the SNP with a disease or drug sensitivity.To do so, Nanosphere scientists employ a two-step process calledClearReadTM technology. This method sand...

Lack of enzyme turns fat cells into fat burners

...olecularbiology. "We found that the adipose in the mutant mice are nowoxidizing fat, hydrolyzing (breaking down using water) fat, and passingit on to the heart and muscle because there is an increase in oxidationof fat in those organs. It also starts oxidizing glucose. In otherwords, the adipose tissue is b...

Fox Chase Cancer Center scientists identify immune-system mutation

...regulate this process have remained obscure. "The mutant HD mice are unable to generate mature helper T cel...present the second time that a naturally occurring mutant strain has been found and bred at Fox Chase. In 1981, the laboratory group of Melvin Bosma, Ph.D., d...

Bound for destruction: Ubiquitination protects against improper Notch signaling

... for nearly a century since theidentification of a mutant strain of Drosophila fruit flies with“notched?wings in Thomas Hunt Morgan’s lab in 1910. Later studiesrevealed that the Notch gene encodes a receptor protein that extendsthrough both sides of the cell membrane and which is capable ofinteracting with ...

Research on Worms Yields Clues on Aging

...us system and life span. The researchers usedthese mutant worms to further pin down the mechanism by which t...d says.Testing the anticonvulsants on longer-lived mutant worms, theresearchers found the drugs further extended their lives, although notto the same degree t...

Mitochondrial DNA mutations play significant role in prostate cancer

...orming ability. The prostate cancer cells with the mutant mtDNAsgenerated tumors that were on average seven ... for oxygen radical production. The tumors withthe mutant mtDNAs generated significantly more oxygen radicals thanthose with normal ntDNAs, suggesting that th...

Mouse brain tumors mimic those in human genetic disorder

...e researchers found that bythree weeks of age, the mutant mice had about four times the number ofsmall blood vessels in the optic nerves and chiasm as control mice.Similarly, microglia were also found in the nerve and chiasm of mutantmice prior to tumor formation."In our judgment, the fact that recruitment ...

Critical role in programmed cell death identified

... place. This feature makes it possible to identify mutant worms, in which cells that should have died instead live. Worms whose cell death program is blocked survive, at least in the lab, with their 131 extra cells. Such studies are impractical in mammals because cell death is essential and animals with a c...

Researchers trace evolution to relatively simple genetic changes

...ded, "we wondered whether the genetic variant (the mutant gene) that controls this trait might still exist in the ocean fish. So we collected large numbers of ocean fish with complete armor, and we found a very low level of this genetic variant in the marine population." So, he said, "the marine fish actua...

Octopuses occasionally stroll around on two arms, UC Berkeley biologists report

...ded, "we wondered whether the genetic variant (the mutant gene) that controls this trait might still exist in the ocean fish. So we collected large numbers of ocean fish with complete armor, and we found a very low level of this genetic variant in the marine population." So, he said, "the marine fish actua...

Zebrafish may hold key to understanding human nerve cell development

...h femalefish produces," she said.By studying these mutant embryos, Piotrowski and her colleaguesdiscovered that during development the zebrafish is "seeded" withfuture hair cells through a process known as placode migration. Theseprecursor cells, called interneuromast cells, eventually go on to makehair cel...

Harmful Bacterium Commonly Found in Poultry May Survive Refrigeration and Frozen Storage Combined

...h femalefish produces," she said.By studying these mutant embryos, Piotrowski and her colleaguesdiscovered that during development the zebrafish is "seeded" withfuture hair cells through a process known as placode migration. Theseprecursor cells, called interneuromast cells, eventually go on to makehair cel...

GenMAPP 2.0 released

...h femalefish produces," she said.By studying these mutant embryos, Piotrowski and her colleaguesdiscovered that during development the zebrafish is "seeded" withfuture hair cells through a process known as placode migration. Theseprecursor cells, called interneuromast cells, eventually go on to makehair cel...

Plants defy Mendel's inheritance laws, may prompt textbook changes

...etic abnormalities carried by both parents. These mutant parent plants apparently have hidden templates con...sis in which each parent plant had two copies of a mutant gene could produce progeny that didn't show the parents' deformity, but rather were normal like the ...

Research Using Mouse Models Reveals A Novel Key Player In The Initiation Of Colon Cancer

...containing one normal copy of the APC gene and one mutant inactive copy) in the presence or absence of Foxl1. Both animals developed tumors, however, in the absence of Foxl1, tumor frequency was more than 7-fold higher. In addition, the animals developed tumors in the stomach. None of the tumors seen in ei...

The Bacteria's guide to survival

...ith normal N. gonorrhoeae to those infected with a mutant strain with defective pili, the researchers found a subset of 52 host genes that had higher activity when the host was infected with the normal bacteria, suggesting that the pulls of the pili were responsible. They then showed that an artificial mech...

X-Ray Beams And Fruit Fly 'Flight Simulator' Aid Scientists' View Of Muscle Power

...arious protein components in muscle function using mutant or genetically-engineered flies. Currently, Maughan is collaborating with Jim Vigoreaux, Ph.D., associate professor of biology at UVM, and Doug Swank of Rensselaer Polytechnic Institute, to determine what parts of the flight muscle proteins are respo...

Glow-in-the-dark zebrafish at UH hold keys to biological clocks

...ives the scientists a better chance of identifying mutant fish whose biological clocks run fast or slow, pro...at a time, the one in a thousand odds of finding a mutant are more easily and efficiently attainable," Cahill said. "Ultimately, this type of research can hel...

Researchers make gains in understanding antibiotic resistance

...es revealed details of erythromycin binding to the mutant form of the Hma ribosome that do not agree with si...nce, even though the antibiotic still binds to the mutant ribosome. The new structural data indicate that the L22 mutation increases the size of a "tunnel" i...

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