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Tag: "must" at biology news

A new mechanism of regulating RNA degradation

...e don't yet understand how SMD is regulated but it must be," said Maquat. "Both Upf1 and Staufen1 can be phosphorylated, so their activities could be regulated by cell signaling pathways, such as those mediated by changes in growth conditions." That would allow the cell to differentially control the level...

FDA Approves Human Hookworm Vaccine for Phase I Safety Trials

...e don't yet understand how SMD is regulated but it must be," said Maquat. "Both Upf1 and Staufen1 can be phosphorylated, so their activities could be regulated by cell signaling pathways, such as those mediated by changes in growth conditions." That would allow the cell to differentially control the level...

UAB scientists discover the origin of a mysterious physical force

...nvolving mechanisms in which colloidal suspensions must be stabilised, such as the mechanisms used to produce paints, cosmetics and food products such as yoghurt and mayonnaise. ...

Priming embryonic stem cells to fulfill their promise

...apeuticpromise, scientists believe that stem cells must first be coaxed todifferentiate, or mature, into precursors of specialized cell typesfound in the body.Embryonic stem cell differentiation is complex and far from fullyunderstood. Scientists are focusing on four types of external inputsknown to be in...

Poor prenatal nutrition permanently damages function of insulin-producing cells in the pancreas

... hormone insulin at all; about 1 million Americans must control this form by taking insulin injections. In type 2 -- a disorder affecting an estimated 18 million Americans -- the pancreas doesn't make enough insulin or the body's cells develop a resistance to its effect. Without insulin, glucose cannot ge...

Timing is everything: First step in protein building revealed

...in intactcells, our results would indicate that it must be very looselyassociated for translation [protein building] to begin."To monitor what was happening to eIF1, the researchers tagged it and arelated part of the ribosome with different fluorescent chemicals. Whentwo fluorescently labeled molecules ar...

Study Links Ebola Outbreaks To Animal Carcasses

... crises, health officials and wildlife researchers must continue to work together in monitoring the region's wildlife for signs of Ebola. Shortly after August 2001, participating agencies founded the Animal Mortality Monitoring Network in collaboration with Gabonese and Congolese Ministries of Forestry an...

Bound for destruction: Ubiquitination protects against improper Notch signaling

...nsmembrane proteins. Proteins in the cell membrane must first beinternalized through a process known as endocytosis before they can bedigested by the proteasome, and indeed other types of ubiquitin ligasehave been shown to operate in the endocytosis of ligand-activatedNotch.The group first showed that an ...

Combination therapy boosts effectiveness of telomere-directed cancer cell death

...te that for this therapy to be effective,telomeres must be in a critically short state, requiring an extendedtreatment duration that can lead to drug resistance and other problems.Dr. Hiroyuki Seimiya from the Japanese Foundation for Cancer Researchin Tokyo and colleagues examined what happens to cancer c...

GATA: a graphic alignment tool for comparative sequence analysis

...te that for this therapy to be effective,telomeres must be in a critically short state, requiring an extendedtreatment duration that can lead to drug resistance and other problems.Dr. Hiroyuki Seimiya from the Japanese Foundation for Cancer Researchin Tokyo and colleagues examined what happens to cancer c...

Learning to fight an adversary that won't stay down

...that our understanding of the activity of microbes must extend beyond the newspaper headlines reporting ou...tors who deal with microbial diseases in hospitals must remain cautious about exposing the bacterial pathogens to the newest and most effective drugs so as ...

The secret lives of whales

...stand the nature of life ?what evolution can do—we must understand these habitats before extinctions occur...here echoes take 10 to 20 minutes to return. “They must have the ability to process low-frequency sounds into images just as dolphins do with high frequency...

Gene therapy converts dead bone graft to new, living tissue

...ers, or tumors that occur adjacent to bones, often must be treated by removing the diseased section of bone and replacing it with the only alternative available ?a donated section of comparable bone from a cadaver. The new splint of bone is then literally screwed into place, giving the patient most of the...

Researchers reveal the infectious impact of salmon farms on wild salmon

...cological costs of industrial scale salmon farming must be quantified as well as the economic ones," says Volpe. "For the migratory runs we studied, there may be very little time left." ...

Gene variations explain drug dose required to control seizures

...thor of the study. "In medicine today, physicians must rely on a one-size-fits-all approach when making d...ogenetic approaches can be put into practice, they must be explicitly evaluated for clinical utility in improving patient outcomes, Goldstein said. The new...

Scientists rid stem cell culture of key animal cells

...ggers stem cell differentiation, Xu deduced, there must be feeder cell molecules that oppose BMP activity. Experiments confirmed this to be true. Next, Xu elevated concentrations of FGF2, a protein routinely used for human embryonic stem cell culture, to test whether FGF2 preserves undifferentiated stem ...

Essential mangrove forest threatened by cryptic ecological degradation

...emphasize that such cryptic ecological degradation must be acknowledged by policy and decision makers if mangrove protection is an aim. The research team argues that early detection of such changes should be adopted and is essential for the prevention of further mangrove degradation. F. Dahdouh-Guebas, S...

Vital step in cellular migration described by UCSD medical researchers

...nderstood by researchers. In order to move, a cell must be polarized so that the molecular processes at the front end and back end are different, leading only to forward movement. One of the first steps in cell migration is the initiation of activity by Rac that extends protrusions out of the cell. These ...

First-ever Compounds To Target Only Metastatic Cells Are Highly Effective Against Breast, Prostate, And Colon Cancers

...on process. "Therefore, the migrastatin analogues must be working on something upstream of those two important steps," Dr. Huang said. Dr. HuangÕs next important step is moving these analogues into clinical trials. "We're trying right now to get a company interested in this, especially because the mice...

Discovery of key protein's shape could lead to improved bacterial pneumonia vaccine

...o carbohydrates. Pneumococcusvaccines for children must instead be modified by binding thosecarbohydrates ...t the long, paddle-shaped extensions ofthe protein must be folded in a specific way in order for CbpA to work.The discovery of the actual shape of CbpA was ...

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