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Tag: "muscular" at biology news

Muscle-targeted gene therapy reverses rare muscular dystrophy in mice

... muscle may reverse the symptoms of a rare form of muscular dystrophy, according to new research in mice condu...ty Medical Center. Infants born with the inherited muscular disorder called Pompe disease usually die before they reach the age of two. The researchers also sai...

Zebrafish may hold key to understanding human nerve cell development

...g leukemia, colon cancer, congenitalheart defects, muscular dystrophy and other birth defects....

Harmful Bacterium Commonly Found in Poultry May Survive Refrigeration and Frozen Storage Combined

...g leukemia, colon cancer, congenitalheart defects, muscular dystrophy and other birth defects....

GenMAPP 2.0 released

...g leukemia, colon cancer, congenitalheart defects, muscular dystrophy and other birth defects....

Rush Physicians Using Gene Therapy For Heart Patients With Moderate To Severe Chest Pains Who Do Not Benefit From Other Treatments

...ly. The DNA plasmid is then taken up by the middle muscular layer of the heart wall near the injection site. Inside the cell, the DNA encoded VEGF-2 expresses itself which in turn stimulates the growth of new blood vessels by promoting the proliferation of endothelial cells in the heart. New blood vessels ar...

Potential treatments for neurofibromatosis

...fects more people than cystic fibrosis, hereditary muscular dystrophy, Huntington's disease and Tay Sachs combined. Now, however, research by IU School of Medicine scientist D. Wade Clapp, M.D., and his colleagues David A. Ingram, Jr., M.D. and Feng-Chun Yang, M.D., Ph.D., have identified a promising target ...

Scientists analyze chromosomes 2 and 4

...on's disease, polycystic kidney disease, a form of muscular dystrophy and a variety of other inherited disorders. Chromosome 2 is noteworthy for being the second largest human chromosome, trailing only chromosome 1 in size. It is also home to the gene with the longest known, protein-coding sequence ?a 280,000...

Young Blood Revives Aging Muscles, Stanford Researchers Find

... some degenerative diseases such as Alzheimer's or muscular dystrophy, such blood-borne factors may be able to reactivate the regenerative cell's ability to repair tissue that has been damaged. ### Postdoctoral scholar Michael Conboy, PhD, and former postdoctoral scholar Irina Conboy, PhD, now an assistant ...

Big differences in duplicated DNA distinguish chimp and human genomes

...ed in human developmental disorders such as spinal muscular atrophy and Prader-Willi syndrome. Parts of those duplicated segments have only single copies in the chimp genome, and it is possible that the chimpanzee is therefore not predisposed to the same diseases as a human. About two-thirds of human-only du...

Discoveries by UAB and Florida scientists may help transplanted organs survive longer

...rried out in rat models, also showed that a single muscular injection of the molecule, interleukin-10 (IL-10), carried in a gene delivery vector, or mechanism, could provide long-term therapeutic effects. Anupam Agarwal, M.D., director of the UAB Nephrology Research and Training Center and senior author of t...

Researchers feed tiny pills of RNA to planarians to identify genes essential for regeneration

... diseases, such as ataxia (inability to coordinate muscular movements), bradyopsia (slow vision), and cancer. Only eight of those genes have a corresponding knockout gene in mice. This means researchers may be able to use planarians to learn about human diseases that can't be studied in other animal models. ...

Gifts from the sea

...that causes children to age unusually quickly; and muscular dystrophy. For a list of MBL researchers and the organisms they use, or for further information on summer research and education at the MBL, please contact Gina Hebert at 508-289-7725. ...

Tetanus toxin found to have therapeutic properties

...as a therapy to treat disorders caused by abnormal muscular contractions such as strabismus, cerebral palsy, anal contractions and torticollis. Recently these toxins have been used even in cosmetics against wrinkles. For these therapeutic and cosmetic applications, the scientists are working with sublethal do...

Carnegie Mellon University research reveals how cells process large genes

...of large human genes associated with diseases like muscular dystrophy, cystic fibrosis and cancer. "We found that many large introns are removed by multiple recursive splicing steps," Lopez said. "These steps involve the sequential excision of smaller subfragments. Our work also indicates that most recursiv...

Reversal of role for a viral protein associated with the development of lymphoma

...of large human genes associated with diseases like muscular dystrophy, cystic fibrosis and cancer. "We found that many large introns are removed by multiple recursive splicing steps," Lopez said. "These steps involve the sequential excision of smaller subfragments. Our work also indicates that most recursiv...

Lance Armstrong through a physiological lens: hard training boosts muscle power 8%

...stic that improved most (was) an 8% improvement in muscular efficiency and thus power production when cycling ...en maximal oxygen uptake." Combining the increased muscular efficiency with a planned 7% reduction in body weight and fat leading up to each Tour de France race...

Chemical 'band-aid' prevents heart failure in mice with muscular dystrophy

...ice with the genetic mutation that causes Duchenne muscular dystrophy, according to scientists at the Universi...cts cardiac muscle, too. Many people with Duchenne muscular dystrophy die in their 20s from heart failure caused by cardiomyopathy, a gradual weakening of the h...

No small feat: First ever gene therapy success for muscular dystrophy achieved

... with gene therapy for the treatment of congenital muscular dystrophy (CMD) in mice, demonstrating that the fo...gene therapy ever being feasible for children with muscular dystrophy can be overcome. Moreover, their results, published in this week's online edition of the P...

Research casts doubt on circulating stem cells

...damaged tissue. Even severe diseases like Duchenne muscular dystrophy (DMD), which destroys all the body's muscles, appeared to be potentially treatable ?indeed, by the simple means of transplanting healthy bone marrow. For boys, DMD is the second most common hereditary disease. Due to a genetic defect, the m...

Gene therapy reverses genetic mutation responsible for heart failure in muscular dystrophy

...l model that is genetically susceptible to a human muscular dystrophy. Reporting in the Oct. 25 edition of the...rapy treatments to be successful, particularly for muscular dystrophies where many organs and tissues are affected throughout the body, intramuscular injection ...

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