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Tag: "mouse" at biology news

Nicotine rush hinges on sugar in neurons

...dy provides the first detailed look at part of the mouse nicotinic acetylcholine receptor (nAChR), one in a large and important group of molecules, known as ion channel proteins, that allow signals to pass between neurons. The results reveal an important role for the sugar molecules in such proteins. “...

Agent slows aging in mice

...ist Richard A. Miller reports early results from a mouse study his lab and two others are conducting for the National Institute on Aging. The study, now in its fourth year, will test as many as two dozen possible anti-aging agents in animals in the next five years. The other centers are the University of T...

Enzyme delivered in smaller package protects cells from radiation damage

...of Medicine, delivered the human MnSOD enzyme into mouse hematopoietic progenitor cells using a newly const... full-sized plasmid. They also irradiated a parent mouse cell line that had not been transfected with MnSOD. After irradiation, the cells were plated in a gr...

Brain inflammation may be friend, not foe, for Alzheimer's patients

...ques.” The new findings hinge on a very special mouse that Shaftel spent three years creating with the g...my. Shaftel genetically engineered a one-of-a-kind mouse that gives him pinpoint control over brain levels of a human molecule known as interleukin-1beta, a ...

Cigarette smoke alters DNA in sperm, genetic damage could pass to offspring

...t their future mate.” Males, whether they are mouse or man, generate a constant supply of new sperm from self-renewing spermatogonial stem cells. Yauk, along with colleagues at Health Canada and McMaster University, studied the spermatogonial stem cells of mature mice that had been exposed to cigaret...

Loss of stem cells correlates with premature aging in animal study

.... Brown explains that in the current study the mouse cells without ATR had an overwhelming amount of DN...Ruzankina, and Amma Asare are currently using this mouse model to discover compounds that preserve stem cells and may, consequentially, suppress aging. ...

Penn researchers link cell's protein recycling systems

...y of HDAC6 to prevent neurodegeneration in several mouse models, including motor neuron disease, Parkinson’s disease, and Huntington’s disease. They are also attempting to identify pharmacologic approaches to augmenting HDAC6 activity....

Herpes virus hijacks DNA repair process

... St. Louis identified a protein that can trick the mouse cell into turning on the DNA damage response. They...bled orf36 in the murine herpes virus and infected mouse cells with it, the virus no longer activated the DNA damage response. The virus's ability to replica...

Mutating the entire genome

...g in short, malformed tail and limbs in the mutant mouse on the left, compared with the skeleton of a normal mouse on the right. The new method promises to speed efforts to learn more about how non-gene portions of ...

Reconstructing the biology of extinct species: A new approach

...es, most of which are mammals ranging in size from mouse to elephant, that habitually move in diverse ways in varied environments. The project is the first large-scale study to document the relationship of the dimensions of the semicircular canals to locomotion. These structures are filled with a fluid...

Turn-ons and turn-offs for neurons

...es which had been inactive in neurons during early mouse development become functionally silenced in the adult brain. Intriguingly, Hasan and colleagues found that gene silencing in the adult brain can be avoided by making neurons produce high levels of gene-specific activators which facilitate “un-silenci...

New vaccine prevents CMV infection and disease in mice

... we successfully created and tested a vaccine in a mouse model with CMV that shows enormous promise for re-...ne system, enabling it to fight the virus.” The mouse vaccine generates an immune response that protects against both infection and development of disease...

A first -- Hebrew University scientist observes brain cell development in 'real time'

...te of Life Sciences at the Hebrew University, used mouse models to study how neurons, or nerve cells, develop from an undifferentiated cellular sphere into a rich and complex cell. This has great significance for the future of brain research, said Dr. Mizrahi, since "the structural and functional complexit...

Adult stem cells from human cord umbilical cord blood successfully engineered to make insulin

...in which complex signals produced by the embryonic mouse pancreas were used to direct adult stem cells to begin developing, or "differentiating," into islet-like cells. As they grew these adult stem cells in the laboratory, the researchers conducted other tests in which the cells to be engineered showe...

Better insight into brain anatomical structures

...that produces images of the anatomic structures of mouse brain which are as clear as those obtained by hist...oparticles gave a view into different areas of the mouse brains—in excellent resolution. "We have developed the first truly biocompatible MRI contrast agent ...

Statin treatment improves spatial memory in mouse models of Alzheimer's

...tory’s earlier findings of improved memory in this mouse model of Alzheimer’s and discovered new information about the neurochemical basis of the beneficial effects. Various studies have found evidence of a strong relationship between memory deficits and high levels of cholesterol in the brain, suggesting ...

Mice with a migraine show signs of brain damage

...d look at the events that happen in the brain of a mouse as a migraine unfolds. The team uncovered a complex, unexpected tale of supply and demand regarding blood flow and oxygen. In short, the team found that the brain develops a voracious demand for energy as the organ attempts to restore the delicat...

Gene malfunctions cause schizophrenia, depression symptoms in mice

...ry, the researchers screened a large population of mouse mutants to isolate two with different mutations in...SC1. They found that, indeed, one of the mutant mouse strains exhibited behavioral abnormalities and memory deficiencies resembling the symptoms of schizo...

Peramivir protects mice from lethal H5N1 infection

...vian influenza virus H5N1, according to results of mouse studies conducted by investigators at St. Jude Children's Research Hospital. Peramivir, an antiviral drug, blocks the ability of influenza viruses to use an enzyme called neuraminidase, thus preventing the release of new virus particles and their ...

pHLIP, a novel technology to locate and treat tumors

... passed through the bloodstream and accumulated in mouse breast tumors grown to different “stages?on the leg of a mouse. The researchers demonstrated that by attaching fluorescent probes to a pHLIP peptide, tumors could be detected. They expect that by attaching and delivering active agents with pHLIP, ...

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