Gut research yields new anti-cancer approach
...nd lung cancer, the tumor types for which Taxol is most used, nearly 100 percent of these tumors eventually become resistant, said Alok A. Khorana, M.D., assistant professor of Medicine at the Medical Center. In cells with more drug efflux pumps, Taxol is not effective (e.g. pancreas, liver and colon), he...A 'traffic light' for neurons means 'go' for improving brain research
... exposure ends. Potential applications The most direct application of optical neuron control is to begin experimenting with neural circuits to determine why unhealthy ones fail and how healthy ones work. In patients with Parkinson's disease, for example, researchers have shown that electrical "...Gene tests and brain imaging reveal early dementia
... disease of the brain, of which Alzheimer's is the most common. Although there is currently no cure for Al...loped it can help us find the people who'd benefit most from treatment in good time." The method is based on the well-established fact that the APOE prot...Row over study puts Korea's scientific community under scrutiny again
...ang Yul Cha, a fertility specialist and one of the most powerful players in the country's struggle for biotech supremacy, writes journalist Jonathan Gornall. It is also threatening to disrupt Korea's efforts to recover scientific credibility in the wake of the recent scandal over Woo-Sok Hwang's stem cell...In obesity, brain becomes 'unaware' of fat
...nergy balance, according to the researchers. In most adults, body weight is relatively constant despite large variations in daily food intake and energy expenditure, Cowley explained. Energy balance is regulated by neural and hormonal signals that are integrated in the brain. Leptin sends signals to...Study shows isolation of stem cells may lead to a treatment for hearing loss
... people become deaf before reaching adulthood. In most cases, the target is the highly specialized hair cells. Docked inside the spiral duct of the human cochlea are ~15,000 hair cells, which are highly specialized neuroepithelial cells that enable us to hear a violin or a whisper. These hair cells dif...Changes in amino acids in the 1918 influenza virus cut transmission
...biology at Mount Sinai School of Medicine. "What's most threatening is the possibility of another pandemic, similar to that of 1918, which was caused by a novel influenza subtype virus capable of causing severe respiratory disease and death," says Dr. GarcĂa-Sastre. "So if we can understand the molecular ...Gene found for rare disorder may reveal new pathway in mental retardation
...facial features as suggestive of CdLS, but for the most part, they would only come to clinical attention for having mild to moderate mental retardation," said Matthew A. Deardorff, M.D., the first author of the study and a fellow in genetics at Children's Hospital. "This study suggests there may be other,...Mine runoff continues to provide clues to microbial diversification
...ch subjects because they have fewer organisms than most communities found in nature. The reason, Hettich n...tal conditions ?a pH of 0.8 -- are too extreme for most organisms to survive. A pH level of 7 is considered neutral and most proteins prefer pH levels betwe...... structures or "molds" to shape hollow spheres and most methods require a lengthy, tedious synthetic or purification procedure. Korean researchers led by Kimoon Kim have now developed a very simple novel approach for the direct production of polymeric nanocapsules. As described in the journal Angewandte C...Major gene study uncovers secrets of leukemia
... pediatric acute lymphoblastic leukemia (ALL), the most common cancer in children. The discovery not only ... The researchers found that the "PAX5" gene was most frequently mutated—altered in about 30 percent of patients. These mutations reduced the level of PAX...Human's ecological footprint in 2015 and Amazonia revealed
...provide. The Amazon Basin is one of the world's most important bioregions, harboring rich array of plant and animal species and offering a wealth of goods and services to society. For years, ecological science has shown how large scale forest clearings cause declines in biodiversity and the availabili...Need oxygen? Cells know how to spend and save
...nges in oxygen levels may be a major challenge for most organisms on Earth." ...Arsenic in chicken feed may pose health risks to humans, C&EN reports
...of the American Chemical Society. Roxarsone, the most common arsenic-based additive used in chicken feed...ured the level of arsenic in the poultry meat that most people consume,?according to the article. The National Chicken Council, a trade association that...Selectivity is ultimate aphrodisiac
Speed daters who romantically desired most of their potential partners were rejected quickly and overwhelmingly, according to a new Northwestern University study. Conventional wisdom has long taught that one of the best ways to get someone to like you is to make it clear that you like them....Power-boosting signal in muscle declines with age
...greater capacity to burn fat. Those properties can most likely be attributed to chronic activation of the AMPK pathway. "In regards to insulin resistance and type 2 diabetes, having more AMPK activity in our skeletal muscle is probably a good thing because AMPK activation stimulates glucose uptake, inc...New compound prevents alcoholic behavior, relapse in animals by blocking stress response
... receptors, and do not accumulate in other organs, most importantly the liver, in ways that would cause concerns about potential side effects, says Heilig. ...Cambodian vulture nests offer hope for species
...ny of slender-billed vultures, one of the world's most threatened bird species. Found in heavily forest...erstanding of which areas are important to the two most threatened species, while simultaneous vulture 'restaurants' across the country provide both an addi...The penalty of having a sister -- why sibling sex matters for male saiga antelopes
...f over 95% in recent years, making them one of the most critically endangered species on earth. Future research will investigate what role sibling sex plays for lifetime reproductive success. The monitoring protocol of saiga antelopes is currently being improved to include non-invasive methods for moni...Nanotextured implant materials: blending in, not fighting back
... of the blood vessel. This contrasts strongly with most of the materials used in implants, which have microscale texture, but are nearly smooth at the nanoscale. When the researchers changed the surface texture of implant materials to better match the natural texture of the endothelium, they found that...