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Tag: "monoclonal" at biology news

Jefferson Virologists Coax HIV Out of Hiding

..., such as IL-2,another immune cytokine, or OKT3, a monoclonal antibody. He suspectssuch strains may be from an unknown viral reservoir in the blood. “IL-7may teach us something,?he says. “We’re not sure why only thesecertain strains are affected. We think we’ve found a new population, anew reservoir of HIV that...

Gene Vaccine Protects Mice Against Development Of Her2/neu Breast Cancer

... breast cancer by “plugging?these receptors with a monoclonal antibody, but this treatment“produces only a passive and transitory immune reaction,?Lachman said.“This vaccine, however, like many that treat microbial infections,appears to create a memory in the immune system that produces a lastingprotective resp...

A comprehensive response to HIV could prevent 10 million AIDS deaths in Africa by 2020

... breast cancer by “plugging?these receptors with a monoclonal antibody, but this treatment“produces only a passive and transitory immune reaction,?Lachman said.“This vaccine, however, like many that treat microbial infections,appears to create a memory in the immune system that produces a lastingprotective resp...

New Treatment Rivals Chemotherapy For Lymphoma, Study Finds

...otherapy, or a combination of chemotherapy and the monoclonal antibody rituximab. These treatments are usually given every three weeks over a span of up to six months and can cause many unpleasant side effects, including nausea, hair loss and infections. Follicular lymphoma is the second most common type of no...

New Insights Into HIV Immunity Suggest Alternative Approach to Vaccines

.... "A light went on when I saw that the rare human monoclonal antibodies had physical characteristics very similar to autoantibodies found in autoimmune disease ?in other words, to the antibodies the normal immune system does not allow to be made," Haynes said. The results provide a new goal for future HIV res...

Promising new West Nile therapy cures disease in mice

...ded to develop the potential treatment--known as a monoclonal antibody--after finding that antibodies taken from...nts. The Washington University scientists made 46 monoclonal antibodies against West Nile virus and then eliminated the less effective ones through a tedious mol...

Bevacizumab Combined With Chemotherapy Improves Progression-Free Survival for Patients With Advanced Breast Cancer

...he two treatment groups. Bevacizumab, a humanized monoclonal antibody** that already has been approved for metastatic colorectal cancer in combination with chemotherapy, is designed to bind to and inhibit vascular endothelial growth factor (VEGF). VEGF is a protein that plays a critical role in tumor angiogene...

First production of human monoclonal antibodies in chicken eggs published in Nature Biotechnology

...entific report of fully functional, human sequence monoclonal antibodies (mAbs) produced in chickens. The antibo... "We expect the demand for more potent anti-cancer monoclonal antibodies and for lower production costs to increase at a rate that will tax existing cell culture ...

Scientists turn tobacco against cancer

...edical College are using tobacco plants to produce monoclonal antibodies -- tiny guided protein missiles -- that...rkers had previously shown that tobacco plant-made monoclonal antibodies could neutralize rabies virus and prevent disease in infected mice. They wanted to find o...

Secrets to antibody's success against West Nile Virus surprise scientists

...ines for related viruses including dengue fever. A monoclonal antibody that can effectively treat mice infected with West Nile virus has an intriguing secret: Contrary to scientists' expectations, it does not block the virus's ability to attach to host cells. Instead, the antibody somehow stops the infectious p...

New Lab Research May Help Those Deafened By Immune System Attack

... or destroy hearing. The U-M team has developed a monoclonal antibody, called KHRI-3, that attaches to IESCA in the inner ear, and can be detected in living animal systems and cell cultures. It has allowed them to study IESCA's role in hearing loss in animal models, and show that damage to the inner ear caused...

Treatments have same target, different responses for lung cancer patients with genetic mutation

...ness of another type of drug that targets EGFR--a monoclonal antibody called cetuximab, which is approved for the treatment of metastatic colorectal cancers that overexpress EGFR. Cetuximab targets EGFR by preventing its activation by extracellular signals, or signals occurring outside of the cell, as opposed ...

Two designer drugs hit same lung cancer target, but only one is effective

...ncer cells containing a mutated EGFR molecule. The monoclonal antibody drug cetuximab (Erbitux) had little effec...e slightly longer in clinical trials. Erbitux is a monoclonal antibody drug that binds to a portion of the EGFR receptor that extends outside the cell. This diffe...

Mechanism for Epstein-Barr virus protein's role in blood cancers discovered

...rontline drug for treating B cell lymphoma, a CD20 monoclonal antibody." The researchers surmise that the first use of future therapies from these studies could be in lymphoproliferative disease in transplant and immunocompromised patients. ...

New study shows patients more willing to consider self-injectable HIV therapy than many physicians anticipate

... integration of other new innovative drugs such as monoclonal antibodies that are increasingly being developed f...asing choice of injectable biotech drugs including monoclonal antibodies, these findings potentially have far reaching implications across a whole range of therap...

Nanoparticles, nanoshells, nanotubes: How tiny specks may provide powerful tools against cancer

... this session include: A nanotube, combined with monoclonal antibodies, is detecting cancer cells, offering a ...nd an engineer have used tiny carbon nanotubes and monoclonal antibodies to detect cancer cells in the laboratory dish. The work might lead to nanotube-based bios...

Targeted drug delivery achieved with nanoparticle-aptamer bioconjugates

...s with high specificity and affinity; analogous to monoclonal antibodies. In the field of cancer nanotechnology, aptamers have the potential to act as targeting molecules - directing the delivery of nanoparticles to tumour-antigens, present on the surface of cancer cells. In general terms, therapeutic nanoparti...

Researchers use 'trickery' to create immune response against melanoma

...s with high specificity and affinity; analogous to monoclonal antibodies. In the field of cancer nanotechnology, aptamers have the potential to act as targeting molecules - directing the delivery of nanoparticles to tumour-antigens, present on the surface of cancer cells. In general terms, therapeutic nanoparti...

GlycoFi announces the first production of antibodies with human glycosylation in yeast

...outh College have reported the first production of monoclonal antibodies with human sugar structures in yeast. This research, published online January 22 and in the February issue of the journal Nature Biotechnology, demonstrates that antibodies with human sugar structures (glycosylation) can be produced in g...

High resolution 'snapshots' detail dynamics of a cocaine antibody

...ed by high concentrations of the drug. A catalytic monoclonal antibody such as 7A1, on the other hand, has the a...ive new approach to treat cocaine abuse." Using a monoclonal antibody endowed not only with high binding ability, but also with sufficient catalytic activity to ...

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