molecules 2 5

Tag: "molecules" at biology news

No carrier necessary: This drug delivers itself

...of it will self-assemble, that is, in solution the molecules aggregate, but not into such big clusters that they settle to the bottom. "It's a controlled formation of a colloidally stable suspension of nanosized crystals,?explained Tymish Ohulchanskyy, Ph.D., UB senior research scientist and a co-author. T...

Twin studies reveal genetic components leading to cardiac and kidney disease

...se filters has increased, allowing leakage of good molecules with the bad. This trait is linked to a heightened risk of cardiovascular disease and premature death. The study shows that both elevated blood pressure and changes to the kidney’s filters are caused by genetic variation at multiple points along th...

OHSU lab finds meth receptor that could lead to therapy

...emical space ?that is, the number of possible drug molecules that could exist ?is incredibly large. Our aim is to mine that space in order to uncover novel therapies." TAAR1 was originally discovered in the laboratory of David K. Grandy, Ph.D., OHSU professor of physiology and pharmacology. Grandy’s lab fou...

Researchers find hepatitis A and hepatitis C attack same protein to block immune defenses

...bers in each liver cell. When specialized receptor molecules detect viruses in the cell, they dock with the MAVS proteins, thereby triggering a sequence of signals ending with the production of interferon beta?a potent inhibitor of virus replication. Recent research has shown that hepatitis C generates a prote...

HIV protein enlisted to help kill cancer cells

...they are linking the anticancer proteins to tracer molecules that selectively bind to cancer cells. "Dr. Mach... tomography) scans," Hawkins says. "By binding our molecules to the tracers, we can deliver them to cancer cells. We've seen phenomenal results in the lab." Ne...

Xie Lab demonstrates the role of microRNA pathway

...today. MicroRNAs are single-stranded small RNA molecules believed to regulate the expression of other genes. The Xie Lab's findings show that the microRNA pathway is essential for controlling self-renewal of two types of stem cells in the Drosophila ovary. "The findings were interesting to us because t...

Notorious cancer gene may work by destroying messenger

...n by destroying particular messenger RNAs (mRNAs), molecules that carry the information used to assemble a prot...yme as Src, which is a member of a large family of molecules called tyrosine kinases. These molecules act like switches that turn other molecules on and off, inc...

Scientists map key landmarks in human genome

... for charting the positions of key gene-regulating molecules called nucleosomes throughout the human genome. The mapping tool could help uncover important clues for understanding and diagnosing cancer and other diseases, the scientists say. Moreover, it may shed light on the role of nucleosomes in the process ...

Scientists create dual-modality microbeads to improve identification of disease biomarkers

... and faster method to detect these types of target molecules in liquid samples using highly porous, micron-size...ds allows the researchers to detect several target molecules at the same time in the same liquid sample. "We use the quantum dots to create a set of beads tha...

New synthetic self-assembling macromolecules mimic nature

..., or skin. But when scientists devise new ways for molecules to self assemble into new materials, it is an important achievement. Researchers with the Macromolecules and Interfaces Institute (MII www.mii.vt.edu ) at Virginia Tech report such a development in the online issue for the Journal of the American C...

Chemical switch triggers critical cell activities

...covery explains how a simple chemical link between molecules called a thioester bond acts like a switch to cont...er bonds are chemical links between two biological molecules that form when a sulfur atom on one of the molecules binds to an atom that is part of the other mole...

Molecular signature may identify cisplatin-sensitive breast tumors

...bout two thirds of breast cancers contain receptor molecules for the hormones estrogen or progesterone, and in recent years antiestrogen drugs like tamoxifen have improved outcomes for women with those tumors. About 20 to 30 percent of tumors, some with hormone receptors, have elevated levels of a growth-prom...

Freeze! Scientists film proteins at work by freezing them at different states

...diseases such as Alzheimer. A high amount of these molecules worsen these illnesses, so scientists are looking for drugs to eliminate them. The enzyme studied by the team acts uniquely in bacteria and its counterpart in humans is more complex. Synthesizing an enzyme like the one studied through biomimetics...

Discovery of an HIV inhibitor in human blood points to new drug class

... 3 million deaths last year alone. A variety of molecules in human blood have been implicated in the inhibition of HIV-1, the researchers noted. However, it had remained elusive which circulating natural compounds are most effective in controlling viral replication in the body. In the new study, the rese...

Parasite infection may benefit MS patients

...r hosts for long periods of time, they can develop molecules that generate strong anti-inflammatory responses, ...estigation is warranted in order to identify which molecules cause immune system effects that dampen the inflammatory reactions normally seen in autoimmune disea...

Scientists uncover new target in cancer mutation puzzle

...on, researchers showed for the first time why some molecules such as Rho are targeted by cancer genes ?and how ... tumors with p53 mutations, we will look for other molecules with similar features," Land said. "Our hope is that this line of research will give us a range of n...

Brain networks strengthened by closing ion channels

...ome patients with ADHD may have genetic changes in molecules that weaken the production of norepinephrine. Treatments for ADHD all enhance stimulation of the norepinephrine receptors. These new data also have important implications for the researchers' studies of more severe mental illnesses like schizophre...

Knocking out survival protein could aid leukemia treatment

...wn in the laboratory. The investigators placed molecules called small interfering RNA (siRNA) inside the cells and found that the tiny molecules greatly reduced the amount of the survival protein, causing many of the cells to die. The effect was...

Batten down the hatches against HIV

...ities to be absorbed by cells and to smuggle other molecules in at the same time. The researchers attached phos...de into the surrounding solution. The required RNA molecules were fastened to the ends of these chains. Once inside the cell, the RNA could easily be split off b...

Triplex assay used to assay duplex genomic DNA

...es additional grooves into which additional YOYO-1 molecules intercalate. "We have decided not to focus on improving probe chemistry at this time, but rather to develop a flow injection based instrument which is matched to our chemistry," continued Daksis. Their Genome Flow® instrument, which employs hardwa...

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