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Tag: "molecular" at biology news

Maine Researchers Find Exceptions to Old Rules of Genetic Inheritance

...years, researchers have sought the biochemical and molecular basis of these phenomena. This work represents a landmark study of the genetics of the t haplotype-it shows for the first time that different genes within the haplotype cause transmission ratio distortion and sterility." The research is published in...

NYU and MSKCC research provides model for understanding chemically induced cancer initiation

... been previously linked with cigarette smoke. This molecular link between chemical DNA damage and cigarette-ass...w chemicals can induce mutations and cancer at the molecular level," added NYU's Broyde. "Such information is needed for devising novel preventive and therapeuti...

Plant Sacrifices Cells to Fight Invaders

...nt cells immediately launch a set of sophisticated molecular responses. Such defense mechanisms, including PCD, are similar to immune responses exhibited by animal cells when they are fighting a disease-causing agent. In fact, PCD is a well-researched, yet still puzzling phenomenon that has been described in ...

A little stress gives beneficial oomph! to immune system

...hor and an associate professor of oral biology and molecular virology, immunology and medical genetics at Ohio State University. "An increase in leukocyte activity and availability may enhance the immune system's ability to protect the body during surgery, vaccination or during an infection". But there is als...

Study reveals dramatic difference between breast cancers in US and Africa

...lls within the breast and often do not present the molecular targets that form the basis of many standard therapies. "We have known for a long time that breast cancer is not one disease and that it may be somehow different in Africa," said study author Funmi Olopade, M.D., professor of medicine and director o...

Building a human kinase gene repository

...edical School lecturer on biological chemistry and molecular pharmacology) mined public databases to collect the sequence information of all identified human kinase genes and have built a gene repository for this gene class. Their work is described in the online early edition of Proceedings of the National Aca...

UCSD research reveals mechanism involved with type of fatal epilepsy

...nes encode the proteins laforin and malin, but the molecular mechanism defining how loss of laforin or malin ca...s work establishes a few testable models as to the molecular mechanism of the disease. Dixon and colleagues are currently designing experiments to test these mod...

Protein Discovery Could Unlock The Secret To Better TB Treatment

...ntibiotics. Scientists believe that uncovering the molecular structure of this protein will lead the way to des...exist in TB bacteria. The paper's unveiling of the molecular structure of Rpf could be crucial to the treatment of TB in the future. Dr John Ward, Dept of Bioch...

Doctors closer to using gene analysis to help trauma patients

... patients and increase understanding of the body’s molecular reactions to injury, including inflammation. The l... the UF Genetics Institute and interim chairman of molecular genetics and microbiology. “For any tool used in clinical medicine, it’s important that people are a...

Measuring Enzymes At End Of Cancer Pathway Predicts Outcome Of Tarceva, Taxol

...s. "Our hope is to be able to use this system as a molecular marker to assess whether an anti-cancer therapy is working." ABSTRACT # 1670 Sensitivity to Tarceva Depends on CDK2 In the first study, M. D. Anderson researchers found that loss of the CDK2 enzyme strongly correlated with a cancer's sensitivity t...

Study reveals candidate targets for anti-retroviral therapeutics

...or mobile genetic elements that are non-pathogenic molecular relatives of retroviruses. In budding yeast, these mobile elements (called Ty ?or transposable yeast ?elements) encode proteins that are homologs of retroviral proteins. The proteins encoded by Ty elements and the steps of the life cycle in yeast are...

Norovirus found to cause traveler's diarrhea

...es of traveler's diarrhea because, until recently, molecular detection methods for these viruses have not been ...r's diarrhea is warranted. The simple, inexpensive molecular diagnostic techniques used in this study to identify Norovirus-positive stool samples could serve to...

Secret of smallpox's success may lead to bioterror cure

...ognize. "It's what we call a 'pathogen associated molecular pattern' ?a biomarker that is only present in your body when you are infected with a virus and that the body knows to look for and respond to," said Jacobs. "The body responds in a lot of different ways, but the main way is it starts producing an imm...

Cellular Defects in Premature Aging Disease are Reversible

...ting in the wrong place. "You can think of it as a molecular Band-Aid®," said Misteli. The researchers inserted their oligonucleotides into the progeria cells and observed that after four days almost all the mutant lamin A transcripts had been eliminated and replaced with the properly spliced counterpart. The ...

Supercomputers to focus brains on AIDS dilemma

...viously faced early deaths. Structural biology and molecular dynamics computer simulations played an important ...ew drug possibilities flow out of a long series of molecular dynamics simulations by McCammon's group. These simulations have focused on the catalytic domain of ...

The biggest family tree ever

...aid Cusanovich, a UA professor of biochemistry and molecular biophysics and a professor in BIO5. "If you ask around here, you find that every tenth person is building a little family tree at home. They go to all the records and they're using Web sites to trace back their history." The UA scientists will analy...

Gene therapy cures inherited liver disease in rats

...mal," said Dr. Brendan Lee, associate professor of molecular and human genetics and a Howard Hughes Medical Investigator at Baylor College of Medicine. Crigler-Najjar syndrome is currently treated by placing the person under special UV lights. It is an unwieldy and time-consuming treatment. While Lee does no...

Master gene controls healing of skin in fruit flies and mammals

... have been conserved, given the differences in the molecular composition of insect cuticle and mammal skin. "The proteins that link together to form the insect cuticle and stratum corneum--the outer layer of mammal skin--are completely different," says McGinnis. "So it is remarkable that flies and mammals sha...

Doing a spin with DNA

... nature releases the torque built up in DNA at the molecular level. The researchers from Delft University of Technology, the Ecole Normale Supérieure in Paris and the Sloan-Kettering institute in New York published their findings in the 31 March 2005 issue of Nature. An artistic impression of the enzyme at wor...

Molecular fossils uncover link between viruses and the immune system

...uencing provided support for this framework at the molecular level. However, as virus sequences diverge rapidly and they do not leave behind physical fossils due to their small size, these methods could not be used in studies of the evolution of viruses. ...

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