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Tag: "molecular" at biology news

Ecological destruction fuels emerging diseases

...Dr. Brooks and his colleagues are using the latest molecular taxonomy tools to classify parasites based on genetic characteristics. "These things are evolutionary accidents waiting to happen," he warns. "This is not something brand new ?it's something old. But in this case it's something that human beings are...

Newly discovered virus linked to childhood lung disorders and Kawasaki disease

...frey S. Kahn and co-workers at YaleUniversity used molecular probes targeting a gene that is common inhuman and animal coronaviruses to screen hundreds of specimens forcoronavirus genetic material. Ultimately, two specimens were identifiedin which the sequence of chemical building blocks of the gene differedfr...

Inexpensive, mass-produced genes core of synthetic biology advances at UH

...to aid the efforts ofresearchers to understand the molecular mechanisms that regulatebiological systems. There are many potential biochemical and biomedicalapplications.?Most immediately, examples include understanding the regulation of genefunction. Down the road, these efforts will improve health care,medici...

Bound for destruction: Ubiquitination protects against improper Notch signaling

The Notch pathway is an important molecular signaling mechanism whose existence has beenknown,... to theproblem confronting cells of how to prevent molecular loose cannonsfrom fouling their precisely ordered workplans....

Combination therapy boosts effectiveness of telomere-directed cancer cell death

...uo: "Tankyrase 1 as a target for telomere-directed molecular cancertherapeutics"....

GATA: a graphic alignment tool for comparative sequence analysis

...uo: "Tankyrase 1 as a target for telomere-directed molecular cancertherapeutics"....

Whole genome fine map of rice completed

...ongping. The goal of the project was to reveal the molecular mechanism of the hybridization advantages, thus providing the theoretical basis for improving output and selecting better strains of agriculture crops. The current publication provided a completed fine map for the paternal strain¡°93-11¡± (Indica), a...

Research on Worms Yields Clues on Aging

...erry Kornfeld, M.D., Ph.D., associate professor of molecular biologyand pharmacology. "We wanted to look in an unbiased way at availablecompounds to see if any of them happened to have anti-aging activity."The researchers grew the roundworm C. elegans in the presence of the 19drugs and found that an anticonvul...

Learning to fight an adversary that won't stay down

...says Dr. Davies. Ironically, he says, advances in molecular biology techniques have shown just how adept these pathogens are at adapting to anything we can throw at them. Innovations such as highly efficient polymerase chain reaction (PCR) have made it possible to identify and study the many genes responsible...

Novel Enzyme Shows Potential As An Anti-HIV Target

...scribed. Adept as HIV is in exploiting its host’s molecular resources, the virus can’t establish a foothold without the services of its skeleton crew. The HIV transcription factor Tat (“transactivator of transcription?, for example, is an essential regulator of HIV gene expression. Without Tat, HIV transcript...

Found: Missing sequence of the human Y chromosome

...d as part of a long-term effort tocharacterize the molecular genetic basis for Y-chromosome-linkedphenotypes. Rappold and colleagues had previously physically mapped theGCY locus, which is thought to be the genetic determinant ofsex-related stature differences in humans and is in close proximity tothe Y centro...

Molecular machine may lead to new drugs to combat human diseases

The crystallized form of a molecular machine that can cut and paste genetic material is... Purdue University researchers froze one of these molecular machines, which are chemical complexes known as a Group I intron, at mid-point in its work cycle. Wh...

Spider Venom Could Yield Eco-Friendly Insecticides

...insects, but not vertebrates. King is studying the molecular structures of the toxins that selectively target t...ce of specific insect pests by locking on to novel molecular targets in the insect nervous system. Because the insects have never encountered chemicals that beha...

Enzyme shown to help protect genomic stability

...regions of the genome from potential destabilizing molecular events. The enzyme helps to keep the genome struct... trigger cancer in humans." "We have identified a molecular mechanism to explain how this enzyme helps keep telomeric DNA silenced and potentially protects the ...

BRCA1 causes ovarian cancer through indirect, biochemical route

... Maxson, Keck School professor of biochemistry and molecular biology and director of the mouse core facility at the USC/Norris Cancer Center. "The whole project was based on creating a mouse that lacks BRCA1 in only its granulosa cells," Dubeau says. "This collaboration was essential to the project's success."...

Scientists decipher genome of fungus that can cause life-threatening infections

...or a broader genomeproject that aims to define the molecular basis for the C. neoformansspecies cluster, which includes three related yet diverged specieswhich differ in virulence attributes, environmental distribution andwhich have been diverging over millions of years of evolution....

Needling Chromosomes Reveals Cell Division Secret

...uestions. We lay the mechanistic groundworkfor the molecular explanations that have to be made. So, our colleagueswho do molecular work are both provoked and challenged by us," he said....

Scientists rid stem cell culture of key animal cells

...onic stem cell lines, Xu and his team explored the molecular interactions within the stem cell growth medium. He discovered that, in certain conditions, a protein known as fibroblast growth factor 2 (FGF2) accomplishes the same critical role that feeder cells are thought to play: ensuring that the stem cells r...

New research questions basic tenet of neuron function

...d that if the two types of vesicles have different molecular compositions, as their findings suggest, those differences may make it possible to independently regulate spontaneous and activity-dependent neurotransmitter release. Spontaneous release is thought to play a role in the development of the neural circ...

Vital step in cellular migration described by UCSD medical researchers

A vital molecular step in cell migration, the movement of cells with...rder to move, a cell must be polarized so that the molecular processes at the front end and back end are different, leading only to forward movement. One of the ...

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