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Tag: "modifies" at biology news

Scientists find missing enzyme for tuberculosis iron scavenging pathway

...ins Dr. Baker. "The N-acetyltransferase chemically modifies the sugar amino group by transferring an acetyl group to it. This inactivates the antibiotic because it can no longer fit into its target." However, in vitro biochemical assays have failed to demonstrate aminoglycoside N-acetyltransferase activity i...

Novel Enzyme Shows Potential As An Anti-HIV Target

...ter (where transcription begins). CDK-9 chemically modifies the RNA polymerase and enhances its transcribing efficiency. The transcription process—including the labyrinthine protein–protein and protein–DNA (and in the case of Tat, protein–RNA) interactions—is highly regulated. One process that figures promin...

Newly Discovered 'Branding' Process Helps Immune System Cells Pick Their Fights

...nerate peroynitrate, a highly potent chemical that modifies many proteins. Unanue's group showed that this chemical modifies the peptides presented by antigen-presenting cells in several distinct ways. For example, they attac...

Best research work in the area of wine growing

... that "the occurrence of a period of hydric stress modifies the hydric relations of the grapevine even when irrigation had been re-established". This effect confirms, "it is not the same in all the varieties and so it would be of great interest to research further into this aspect of the hydric relations of t...

Enzyme's newly discovered role may make it target for arthritis treatment

... surface can send a signal back into the cell that modifies the cell's behavior, allowing it to do things like secrete inflammatory factors," Pham explains. "The proteases' ability to affect integrin rearrangement is dependent on their catalytic activity, and that's an ability that can be taken away from them...

Study finds adult stem cells can replicate

... surface can send a signal back into the cell that modifies the cell's behavior, allowing it to do things like secrete inflammatory factors," Pham explains. "The proteases' ability to affect integrin rearrangement is dependent on their catalytic activity, and that's an ability that can be taken away from them...

Scientists take aim at virulent bacteria by decoding machinery of key control enzyme

...ny bacteria. Each time the bacteria reproduce, Dam modifies the A (adenine) nucleotide in the DNA sequence GATC through a chemical reaction known as methylation. Methylation is a biological process used to tag a variety of molecules, including DNA, and is important in cellular processes such as regulating gen...

Spiders help scientists discover how muscles relax

...dehydration and staining of a tissue sample, which modifies the structure of the specimen and distorts its shape. Cryo-electron microscopy avoids these problems by rapidly freezing the sample. Using the new technique, the researchers were able to visualize the muscle tissue in a form closer to its structure i...

How Rickettsial pathogens break into cells

...ts, and that the protein modifier called ubiquitin modifies Ku70 as soon as the bacteria interact with it. This step is critical for cell entry. "Whether other Rickettsia and other pathogens use Ku70 as a receptor is still unknown," Cossart said. ...

First demonstration of 'teaching' in non-human animals

...animal behaviour, an individual is a teacher if it modifies its behaviour in the presence of a naïve observer, at some initial cost to itself, in order to set an example so that the other individual can learn more quickly. Professor Franks said: "We also believe that true teaching always involves feedback i...

Salmonella bacteria use RNA to assess and adjust magnesium levels

...ences a low-magnesium environment, phoQ chemically modifies phoP. The changed phoP binds to DNA, increasing the number of times instructions for making MgtA and over 100 other proteins are copied from DNA. But when Salmonella encounters a high-magnesium environment, phoQ deactivates phoP, and fewer copies of ...

Inflammation and drugs to control this activity studied in a variety of tumors sites

... previous research in animals has shown that AMACR modifies a component of ibuprofen that enhances its chemopreventive effects. "This is the first study to corroborate the biological data at a statistical level in humans," she said. Her team's results need to be verified in other populations, she said. "Wh...

Rehydrate -- your RNA needs it

...l modification spreads throughout the molecule and modifies the structure elsewhere, even at quite a distance," Walter said. Water facilitates the process by increasing the number of hydrogen bonds and making the ribozyme behave as an interconnected whole. Walter and coworkers also found evidence that wate...

Gene first linked to rare disease may trigger skin cancer, other tumors

...lity to keep tumors at bay. The enzyme chemically modifies the cancer-promoting protein Bcl-3, first identifi..., they reported. Once there, the protein binds and modifies the cancer promoter Bcl-3 to prevent its nuclear accumulation. In addition to elucidating the cause...

UCSD researchers create roadmap to integrin activation

...in and the enzyme protein kinase C ?an enzyme that modifies other proteins ?we found we can get the cell to respond to certain agents that, in turn, activate platelet integrin GPIIb-IIIa." Using a synthetic approach, the scientists engineered an integrin-activated pathway. By adding protein kinase C, talin ...

Single molecular 'mark' seen as pivotal for genome compaction in spores and sperm

...olecule in question is a phosphorous molecule that modifies a histone. Histones are relatively small proteins around which DNA is coiled to create structures called nucleosomes. Compact strings of nucleosomes, then, form into chromatin, the substructure of chromosomes. To test the team's observations, Krishn...

Mayo discovers protein as potential tactic to prevent tumors

...ed that when errors in genes are irreparable, CDK2 modifies another cellular protein -- FOXO1 -- to send a signal that results in the death of the cell. This protein-to-protein relationship invites targeted drug intervention to control unregulated growth of cancer cells. "Quality control within dividing ce...

Single molecule extends fat mice lives by reversing gene pathways associated with disease in obese

...which has the same enzymatic activity as Sir2, but modifies a wider variety of molecules throughout cells. Indicators in this study show that resveratrol might also be activating SIRT1 in mice, as well as other known longevity pathways. How the Study Was Done This study examined three groups of mice, o...

New biofuels process promises to meet all US transportation needs

...ire U.S. transportation sector." The new approach modifies conventional methods for producing liquid fuels from biomass by adding hydrogen from a "carbon-free" energy source, such as solar or nuclear power, during a step called gasification. Adding hydrogen during this step suppresses the formation of carbon...

New sucker-footed bat discovered in Madagascar

...luded only one species. The new research, however, modifies both of these ideas. The researchers determined that Myzopoda is not endangered by the loss of the moist tropical forests because the bat appears to have adapted very well to the large broad-leaf Ravenala that are often pioneering plants in zones w...

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