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Tag: "modifications" at biology news

New findings challenge established views on human genome

...rstanding of how DNA replication is coordinated by modifications in histones. “Teamwork was essential to the success of this effort. No single experimental approach can be used to identify all functional elements in the genome. So, it was necessary to conduct multiple, diverse experiments and then analyze ...

'Insulator' helps silence genes in dormant herpes virus

...ve shown that nearby regions of the genome contain modifications indicative of silenced chromatin. The patterns found resemble well-studied regions where insulators are found in both yeast and chicken, namely the yeast mating loci and chicken globin locus. To see if insulators play a role in silencing viral gen...

Latent memory of cells comes to life

...mportantly, nucleosomes can carry various chemical modifications that either allow, or prevent, the expression of the DNA wrapped around them. Every time a cell divides into new cells, its double-stranded DNA splits into two single strands, which then each produce a new double-strand. Nucleosomes though are no...

Revealing the machinery underlying the 'plastic' juvenile brain

... ability of visual experience to drive the histone modifications that are necessary for neural rewiring. The researchers concluded that the mechanism they discovered "might be important for plasticity in the visual cortex during the critical period, and its downregulation could be involved in the closure of the...

Natural antibiotics yield secrets to atom-level imaging technique

...it sits in the cell membrane," providing clues for modifications that might make synthetic AMPs even more effective in overcoming ever-increasing bacterial resistance. For instance, rearranging parts of the molecule might make it fit into the membrane better, resulting in greater effectiveness with smaller amounts...

Mutation improves memory, may lead to memory-enhancing pill

...re thought to underlie these two components. While modifications of pre-existing proteins are sufficient for the transient changes, new gene expression is required for those that are sustained," the researchers said, emphasizing that a gene's expression depends on both its transcription into messenger RNA and the ...

Study finds surfing safer than soccer

...ional surfers and to evaluate the effectiveness of modifications in surfing equipment on reducing the incidence of injury. ...

A new study of living cells could revolutionize the way we test drugs

...c fields in superconductors*. Unfortunately, these modifications reduced the sensitivity of the technique, and the normal activity of the yeast cell could not be detected. This is the first time such a technique has been used on a living cell. Not to be defeated, the researchers went about livening things up. T...

Putting an old drug to a new use

...oratory to clinic will be targeted pharmacological modifications of the compound to separate nifedipine's effect on iron metabolism from its established action on blood pressure. "Our discovery is an excellent example of how the combination of basic research and the expertise of clinicians can yield results th...

Gene that makes people 'early to bed and early to rise' demystified

...t "phosphorylation" prevents a cascade of chemical modifications that are normally primed by the initial event. Moreover, they show that the human gene inserted into otherwise normal mice causes them to rise early, symptoms that mirror those in people with FASPS. In contrast, a mutation that mimicked an increas...

Speeding 'fingertip' discovery -- 20 years of protein info in 1 place

...aking up proteins more gently and keeping chemical modifications like phosphorylation intact. Previous spectrometry... and his team now are curious about other chemical modifications of proteins, which are the “business-end?products of our genes. “There is evidence of other, more f...

Liposuctioned fat stem cells to repair bodies

...th a cell’s epigenetic status, the subtle chemical modifications of DNA and its surrounding histone proteins. Epigenetic marks contribute to switching genes on and off, and stem cells rely on them heavily as they divide and mature. The Oslo team has found that low rates of DNA methylation, for instance, boost the ...

Something new under the sun

...ase humidity and reduce the temperature. Thanks to modifications and Van Ooteghem's new control system less energy is lost and excess heat is reused. This means that sustainable energy can be used to control the climate in the greenhouse efficiently. Control system Van Ooteghem has developed a control sy...

New technique boosts size of proteins that can be analyzed

... this approach reveals less information concerning modifications to proteins. Such important cellular processes as ...ications. Therefore, the method rarely locates all modifications in newly isolated proteins. "Each approach has different strengths and weaknesses," said Mi Jin, a...

Selecting life: Scientists find new way to search for origin of life

...cientist Andrew Steele and his team, has developed modifications of this tool to study molecule/mineral interactions. The scientists have devised protocols for cleaning mineral surfaces, spotting the surfaces with up to 96 different organic species, washing the surfaces to remove molecules that don't adhere to a m...

Detailed 3-D image catches a key regulator of neural stem cell differentiation in action

...past there has been a lot of emphasis on chromatin modifications and physical access to genes, but Scp1 regulates the activity of the enzyme that transcribes genes directly," he adds. Scp1 is not the only protein that directly influences the activity of RNA polymerase II. A constantly fluctuating brigade of enz...

An advanced genetic diagnostic method for multiple myeloma

...er each patient a treatment adapted to the genetic modifications that he or she presents, which, while they may not provide a cure for the disease, will make it possible to transform it into a chronic and asymptomatic pathology. ...

An artificial cornea is in sight, thanks to biomimetic hydrogels

...at Santa Clara University, consulted about surface modifications for cellular adhesion. The researchers are now testing the material for biocompatibility in animal models. Animals have tolerated artificial corneas with no problems in trials as long as eight weeks, Ta says. The material remains perfectly clear, h...

Researchers find protein that silences genes

... are often silenced by DNA methylation and histone modifications in cancer cells, contributing to tumor growth. And... Using antibodies that recognize specific histone modifications that occur on the genes when they switch from off to on, the group was able to confirm that the deac...

DOE publishes research roadmap for developing cleaner fuels

...ansported, stored and distributed with only modest modifications to the existing infrastructure and can fuel many of today's vehicles. The new roadmap was developed during a December 2005 workshop hosted jointly by the Office of Biological and Environmental Research in the Office of Science and the Office of th...

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