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Tag: "modification" at biology news

Inexpensive, mass-produced genes core of synthetic biology advances at UH

...slow (and tedious) process of genecloning, or gene modification (mutations, deletions, etc). Devices the size of a pager now have greater capabilities thancomputers that once occupied an entire room. Similar advances are beingmade in the emerging field of synthetic biology at the University ofHouston, now allowin...

Breakthrough Microarray-based Technology for the Study of Cancer

...NAS paper, Agilent'sbreakthrough is founded on the modification of its gene-expressionprofiling microarray technology to improve its utility for DNA analysisapplications. This new platform provides high sensitivity, enabling CGHresearchers to reliably identify the single copy deletions inchromosomes that have bee...

Genetically modified natural killer immune cells attack, kill leukemia cells

...hile in remission and then reinfused after genetic modification if the patient suffers a resurgence of the leukemia. "We look forward to seeing this strategy being added to the management of children with ALL," said Chihaya Imai, M.D., the postdoctoral student who did most of the work on this project. ...

New RNA polymerase discovered in plants

...ethylation is a vital process involving a chemical modification in cytosine, one of the four chemical subunits of DNA. Without proper DNA methylation, higher organisms from plants to humans have a host of developmental problems, from dwarfing in plants to tumor development in humans to certain death in mice. Pik...

Variation in women's X chromosomes may explain differences among individuals, between sexes

...y of the female's X chromosome are switched off, a modification known as X inactivation. Originally, scientists had assumed that the inactivation process resulted in complete silencing of the genes on the second X chromosome, Willard said, in order to leave both sexes with the same activity level, or dosage, of ...

Genetically Modified Natural Killer Immune Cells Attack, Kill Leukemia Cells

...hile in remission and then reinfused after genetic modification if the patient suffers a resurgence of the leukemia. "We look forward to seeing this strategy being added to the management of children with ALL," said Chihaya Imai, M.D., the postdoctoral student who did most of the work on this project. ...

Protein helps regulate the genes of embryonic stem cells

... called "eed," is needed for an essential chemical modification of many genes. Embryos cannot survive without the modification. The findings appear in the May 24 issue of the journal Current Biology. The research offers an important contribution to a new wave of thinking in genetics: that not all human disease s...

Putting ecology back into river restoration

... is to do no lasting harm. "For example, a channel modification project should minimise loss of native vegetation during river reconstruction, and should avoid the fish spawning season for construction work," Palmer explains. The final criteria is ecological assessment. According to Palmer: "It is critical that t...

Brain May Be Less Plastic Than Hoped

...ation in these areas might then depend more on the modification of existing patterns of connectivity, be it subcortical, feedback, or other broad area-to-area connections. Of course, that is highly speculative. It is also conceivable—although in our opinion less likely—that in neocortical areas other than the pri...

Sponges as drugs

...ced techniques such as chemical synthesis, genetic modification and sponge cell culture are realised, rearing in the sea remains the most reliable and effective method for obtaining the large quantities of sponge biomass, necessary for developing drugs. However, sea rearing can only be used for the large-scale p...

UCR chemist part of team identifying new areas of gene regulation

...vered in 1991 that sites of histone acetylation, a modification of the protein, play a fundamental role in the reg...ity," he said. "We show for the first time that a modification of a histone at the core of the protein, not the end, can regulate genes," Grunstein added. ...

Modified collagen could yield important medical applications

...neering was scheduled to describe the new collagen modification process and its potential medical uses in an Aug. 30 presentation in Washington, D.C., at the 230th annual meeting of the American Chemical Society. His team also published a paper on the work earlier this year in the Journal of the American Chemical...

Unusual antibiotics show promise against deadly 'superbugs'

...neering was scheduled to describe the new collagen modification process and its potential medical uses in an Aug. 30 presentation in Washington, D.C., at the 230th annual meeting of the American Chemical Society. His team also published a paper on the work earlier this year in the Journal of the American Chemical...

Biologists determine genetic blueprint of social amoeba

...on appears to lead to loss of genes as well as the modification of copies of old genes. As each new genome is sequenced, we learn more about the history and physiology of the progenitors and gain insight into the function of human genes." In 1989, Loomis and Kuspa, then a postdoctoral fellow in Loomis' laborator...

Promiscuous Catalytic Activity Possessed by Novel Enzyme Structure

...ng a fat-like molecule called a prenyl group. That modification can have a huge impact on where the aromatic molecule goes within the cell, and what sort of effects it has when it reaches its target. “When you make that so-called hybrid molecule, all the chemistry associated with the original compound changes,?s...

Stem cell training program to make its Stanford debut

...ng a fat-like molecule called a prenyl group. That modification can have a huge impact on where the aromatic molecule goes within the cell, and what sort of effects it has when it reaches its target. “When you make that so-called hybrid molecule, all the chemistry associated with the original compound changes,?s...

Gene therapy advance treats hemophilia in mouse models

...ts promoter is liver-specific," McCray said. "This modification helps prevent negative side effects. For example, if the gene were expressed in immune cells instead of liver cells, it could lead to a damaging immune response." McCray said the team now is studying additional ways to make the hybrid vector express...

Gene Bridges And Covalys To Develop Restriction-Enzyme-Free SNAP-tag Gene Fusion Kits

...ning, enables cloning and precise manipulation and modification of DNA molecules regardless of restriction sites a...ful for the rapid generation of targeting vectors, modification of BACs and E. coli chromosomes, as well as viral engineering. Gene Bridges, an EMBL spin-off, is he...

Vineyard weeds found to host Pierce's disease of grapes

...ctor, either through insecticide sprays or habitat modification to remove insect breeding host plants. Our study reinforces the need for weed control in irrigation ditches and roadsides adjacent to vineyards, in regions with chronic Pierce's disease and established populations of sharpshooters, especially in warm...

Modification of program enables prediction of gene transcription

A modification to an "ace" gene prediction program by computer sc... thereby defining the first exon of the gene. The modification to the gene prediction software TWINSCAN is called N-SCAN. Michael Brent, Ph.D. professor of compute...

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