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Tag: "models" at biology news

Protein connections: A network to understand disease

...we know can change the course of disease in animal models were also identified as common partners." "In this network are spots where many proteins interact," she said. "These are key proteins." These proteins, she said, could be extremely important in insuring normal neuronal function. "When you step b...

Bacteria can help predict ocean change

...ding to a new study that may lead to more accurate models of ocean change. Scientists have long endorsed t...ia behave predictably, they can be used to improve models for ocean change. By including bacteria, which make up the vast majority of species on land and se...

Case Western Reserve University researchers find protein associated with brain cell death

...oxidative damage observed in both human and animal models of AD, report the researchers. This current study builds on prior research studies that produced evidence of the microglia mounting this inflammatory immune response by whittling down the various components in that reaction. "We have recently ...

Scientists discover a genetic code for organizing DNA within the nucleus

...tioning code, the research team used probabilistic models to characterize the sequences bound by nucleosomes, and they then developed a computer algorithm to predict the encoded organization of nucleosomes along an entire chromosome. The team's findings provided insight into another mystery that has long...

NHGRI announces latest sequencing targets

...n addition, some primates are important biomedical models because of their genetic, physiologic and metabolic similarities with humans. For example, the rhesus macaque is an essential research model for drug development, neuroscience, behavioral biology, reproductive physiology, endocrinology and cardiovasc...

The vicious cycle of rainforest destruction

...side. Using these measurements, detailed computer models will be created to look at the impact of changes i...fall. These changes will then be fed back into the models to determine their cumulative impact and ultimately predict global climate change. The researchers ...

On the track of tiny larvae, a new model elucidates connections in marine ecology

...howed that combining the oceanographic and genetic models allowed the researchers to successfully predict ge... approach to integrating genetic and oceanographic models helps predict genetic links among several locations and is an important new tool for the management ...

UF scientists restore sight to chickens with blinding disease

... enzyme essential for sight. The condition closely models a genetic disease in humans that causes Leber congenital amaurosis type 1, or LCA1. About 2,000 people in the United States are blind because they have a disease that falls in the LCA family. "Enabling chickens that can't see to peck and eat after t...

UC Davis researchers move biotechnology closer to replacing electronic pacemakers

...tudy offers positive and direct evidence in living models that bioengineered cells can replace the electroni...e current study moves research beyond using animal models such as mice and rats, whose hearts can beat up to 600 times per minute. Large animals such as pigs ...

Scientists aim to thwart use of flu as bioweapon

...ch of the improvement is due to early mathematical models that helped scientists and physicians understand a...not understood completely," said Wu. "Mathematical models will help guide flu experts to ask the right questions, so that we understand it more thoroughly tha...

Sandia work launched on space shuttle shows live cells influence growth of nanostructures

... Groups of such long-lived cells may also serve as models to investigate how tuberculosis bacteria survive long periods of dormancy within human bodies. En masse, they also may be used to generate signals to repel harmful bacteria from the surfaces of surgical tools like catheters. Finally, the method a...

Mass. General study finds potential ovarian cancer stem cells

... the first time stem-like cells have been found in models of ovarian cancer and in cells associated with human ovarian cancer." Several recent studies have identified tiny populations of tumor cells that appear to act like stem cells, driving the tumor's ability to grow and spread. If some of these speci...

Parkinson's disease mechanism discovered

... new way to rescue dying neurons in several animal models of Parkinson's disease. According to the research...alpha-synuclein caused neurodegeneration in animal models of Parkinson's disease, but little was known about alpha-synuclein's normal cellular function or how...

Brain enzyme treatment relieves memory lapse in Alzheimer's mice

... of learning known to be impaired in several mouse models of Alzheimer's disease. For fear conditioning, mice treated with the Uch-L1 inhibitor and control mice were placed in a novel context (a fear-conditioning box) and exposed to a tone paired with a mild foot shock. Their ability to learn fear was te...

Key stress protein linked to toxicities responsible for Parkinson's, Alzheimer's

...showing that PDI can be a target of NO in cellular models of Parkinson's disease and human neurodegenerative disease." A protein's structure determines its function. Genetic defects as well as exposure to free radicals or possibly other types of cellular stress can cause small structural defects that lea...

Studies suggest new brain protein may help in treating schizophrenia, insomnia and anxiety

...ciated with mental disorders and developing animal models that lack parts of the NPS system in order to better understand its functions. ...

Synthetic molecule causes cancer cells to self-destruct

...und's efficacy in cell cultures and in three mouse models of cancer. The testing was performed in collaboration with William Helferich, a professor of food science and human nutrition at the U. of I., and Myung-Haing Cho at Seoul National University. The researchers also showed that PAC-1 killed cancer cell...

Human behavior changes the number of strains of infectious diseases

Simple models predict that only one strain of an infectious disease can exist at one time, but observation suggests otherwise. In a study in the August issue of The American Naturalist, Ken Eames and Matt Keeling (University of Warwick) use a mathematical model to...

DOE JGI releases IMG 1.5 with curated archaeal genomes

...mation. DOE JGI has embarked on curating the gene models of microbial genomes culled from public sources. T...now contains 22 archaeal genomes with curated gene models and detailed documentation of the methodology and standards employed for achieving this goal. A sep...

Marine 'dead zone' off Oregon is spreading

... and his colleagues are working on new circulation models that may allow scientists to predict when hypoxia and these "dead zones" will occur. No connection has been observed between these events and other major ocean cycles, such as El Niño or the Pacific Decadal Oscillation. The lack of wide-scale ocean ...

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