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Tag: "mobilize" at biology news

Leprosy microbes lead scientists to immune discovery

...s are unable to produce the [CD1b+] cells that can mobilize T-cells, these people don't respond well and become much sicker," commented Bloom. "This research gives us insights about how the body develops protective immunity against bugs that invade our cells--or fails to. Now we know the players, and we would...

A little stress gives beneficial oomph! to immune system

... attacks the body. "Understanding mechanisms that mobilize leukocytes to potential battle stations during stress could help us figure out ways to boost the immune response when it could be most helpful to do so, such as during surgery, vaccination or infection," Dhabhar said. "And it could also help us tone ...

Stem cell mobilization therapy appears to be ineffective in repairing damage caused by heart attack

...farct size. In conclusion, use of G-CSF therapy to mobilize bone marrow–derived stem cell does not improve left ventricular recovery in patients with acute myocardial infarction after successful mechanical reperfusion," they write. ...

How HIV 'exhausts' killer T cells

...ses, but did not investigate helper T cells, which mobilize the immune system against infection. Ahmed's findings prompted Walker and his colleagues to explore the role of the PD-1 pathway in a large population of HIV-infected patients in the KwaZulu-Natal province of South Africa. The province is at t...

A new tool against brain disease

...ses, but did not investigate helper T cells, which mobilize the immune system against infection. Ahmed's findings prompted Walker and his colleagues to explore the role of the PD-1 pathway in a large population of HIV-infected patients in the KwaZulu-Natal province of South Africa. The province is at t...

Research highlights how bacteria produce energy

...surfactants) to clean oil off of rock surfaces and mobilize oil stuck in small cavities. However, up till now,...and whether they will make enough biosurfactant to mobilize entrapped oil," says McInerney. He and his colleagues were able to inoculate an oil reservoir with ...

Combination therapy with a monocloncal antibody and a vaccine leads to tumor rejection

... Researchers continue to work on devising ways to mobilize anti-tumor Teff cells in order to better shape the immune response to tumors. Previously, James Allison and colleagues from Memorial Sloan-Kettering Cancer Center, New York, demonstrated that an anti–CTLA4 monocloncal antibody used in combination wit...

Bone marrow may restore cells lost in vision diseases

... occurring." Researchers want to discover ways to mobilize an elderly patient's own cells to travel to the injury site to make repairs. "The dogma has been that we're born with a fixed amount of RPE, but there is growing evidence retinal progenitor cells exist in the adult," said Lawrence Rizzolo, Ph.D., a ...

Healing the heart with bone marrow cells

... with defective c-kit bone marrow cells, could not mobilize these cells to race towards the injured site and regenerate the injured heart. Their heart function was dramatically impaired and, 42 days after a heart attack, their hearts dilated to twice the size of the normal mouse heart. However, the heart func...

A surprise about our body clock

... with defective c-kit bone marrow cells, could not mobilize these cells to race towards the injured site and regenerate the injured heart. Their heart function was dramatically impaired and, 42 days after a heart attack, their hearts dilated to twice the size of the normal mouse heart. However, the heart func...

Drug can quickly mobilize an army of cells to repair injury

... Louis demonstrated that a drug called AMD3100 can mobilize angiogenic cells from bone marrow of human patient...ffective. But Link feels it may make more sense to mobilize the cells into the bloodstream with agents like AMD3100. "It might be better to let the appropriate...

Key to zebrafish heart regeneration uncovered

...of the cardiovascular system. The epicardial cells mobilize to cover the wound and blastema, and help provide new blood vessels, creating a protective niche where the new heart muscle can grow." The researchers found that biochemical signaling between the blastema and the epicardium is controlled in part b...

How fish mend a broken heart

... "It is tempting to speculate that the ability to mobilize epicardial cells and cultivate such a cardiogenic environment is a primary reason why zebrafish, as opposed to other laboratory models, effectively regenerate [heart muscle]," the researchers concluded. Indeed, they added, mammalian hearts typically ...

Research project tackles 'regeneration' gap

... of brain diseases, scientists may look at ways to mobilize and reinforce the body’s own supply of adult stem cells to protect against or fight Alzheimer’s and Parkinson’s diseases, cancer, multiple sclerosis and traumatic injury. The project has received support from two private gifts ?from Jon and Beverl...

Discovery could lead to better control of hemorrhagic fever viruses

...ant on activated immune cells ?the very cells that mobilize to fight the viruses ?making them especially vulnerable to infection. "This may help explain why mortality is so high," says Choe, the study's senior author. Choe now hopes to translate these findings into treatments to contain natural or int...

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