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Tag: "microscopy" at biology news

Neuronal 'traffic jam' marks early Alzheimer's disease

...d when we looked at those swellings using electron microscopy and biochemical markers, they looked just like the axonal transport blockages we saw in fruit flies." Detailed studies of the neurons revealed what Goldstein termed a "traffic jam" of transport-related proteins, organelles and sac-like vesicles that ...

Plants respond similarly to signals from friends, enemies

... foe are also remarkably similar. Using high-tech microscopy and florescent imaging techniques that allow for real-time, three-dimensional study in living cells over time, the NC State researchers discovered that the model legume Lotus japonicus responded similarly to signals from both rhizobia, the friends th...

Scientists Replicate Hepatitis C Virus in Laboratory

...hin the human liver cells in the culture. Electron microscopy showed evidence of high levels of viral particles resembling fully-formed HCV outside of the human liver cells in the culture medium. The researchers believe that the HCV construct contained within the human liver cells behaved like a true HCV infect...

The transparent organism: EMBLEM and Carl Zeiss give labs a unique look at life

...nates a problem that has plagued three-dimensional microscopy in the past: researchers could obtain excellent resolution in the plane of the microscope slide, but resolution along the direction of the viewer was very fuzzy. In SPIM, a sample is passed through a thin sheet of light, capturing high-quality images...

Open microfluidic and nanofluidic systems

...hologies as observed by atomic (or scanning) force microscopy (AFM) are shown in Figure 1. When the AFM experiments were first performed, it was not known how to produce a certain liquid morphology since there was no systematic theory for the dependence of this morphology on the materials properties and on the...

Scientists discover unique microbe in California's largest lake

...ked with Selker, formerdirector of the UO electron microscopy facility, to compare thecellular structure of the new organism with that of the symbiotic formof Acaryochloris. Blankenship and Olson compared its pigments withthose of A. marina, one of the symbiotic species."Chlorophyll d is a pigment that is inter...

Anammox bacteria produce nitrogen gas in oceans' snackbar

...e membrane lipids (ladder molecules), fluorescence microscopy and DNA analyses of water samples was used to proof the abundance of anammox bacteria in the Atlantic Ocean. The discovery of anammox bacteria in the open ocean has major consequences for our understanding of the global nitrogen cycle. Models of glob...

Confocal imaging promises early detection of skin cancer

... Dr Sheblee. The original idea for using confocal microscopy to look deeper into skin came from German company ...stepped UK firm VisiTech International. “Confocal microscopy allows you to optically section through objects,?says Dr Sheblee. “It’s like a biopsy without the pa...

Natural Killers Could Lead to New Hepatitis Treatments

...adapted a technique called intravital fluorescence microscopy that enabled them to observe in real time the behavior of the tagged cells in the livers of mice. “The startling discovery was that these NKT cells just move within the sinusoids intravascularly,?said Littman. By contrast, he said, immune cells in t...

The making and breaking of microtubules

...ost to the point of stopping them." Cryo-electron microscopy (cryo-EM) is capable of capturing such polymer structures without having to break them down and crystallize single subunits for x-ray diffraction analysis. X?ray diffraction might allow higher resolution, but it would lose all information concerning ...

Researchers seek to discover what really happens when a virus enters the body

...developed that reflects the physics of fluorescent microscopy ?also estimates and corrects the effect of the microscope's uneven illumination and the markers' spectral overlap," Bell explains. As Bell and Duca are able to develop their composite images, they will be able to mathematically produce a quantitati...

Spiders help scientists discover how muscles relax

... Massachusetts Medical School to use cryo-electron microscopy to answer questions about the thick filament's str... that could not be answered with existing electron microscopy techniques. Standard electron microscopy requires dehydration and staining of a tissue sample, whi...

Microscopic brain imaging in the palm of your hand

...accomplish using conventional techniques. Electron microscopy can't be used on living tissue, and optical (light) microscopy can't penetrate very deeply into tissue because light scatters as it travels through tissue near the...

Otter adaptations: How do otters remain sleek and warm

...ially adapted underhairs. Using scanning electron microscopy and polarizing light microsopy, John W. Weisel, Ph...el examined wolf prey hair with light and electron microscopy with the idea of accurately identifying wolf diet from wolf scat. "While we have engaged molecular b...

Genome Sequence for Haemophilus Influenzae Completed

...ially adapted underhairs. Using scanning electron microscopy and polarizing light microsopy, John W. Weisel, Ph...el examined wolf prey hair with light and electron microscopy with the idea of accurately identifying wolf diet from wolf scat. "While we have engaged molecular b...

Hunt for human genes involved in cell division under way

...eir impact on cell division monitored by live cell microscopy to understand each gene's role in cell division. "To our knowledge, we are the first group to take on this systematic search through the genome in live cells. We will use the most potent RNAi reagent for this study, which is usually out of reach for...

New law for resolution allows unprecedented sharpness in fluorescence microscopy

...al publication [3], the researchers show that STED microscopy allows one to image lithographic structures (which had been previously dyed with a fluorescent dye) of width as small as 40-80 nm, a size previously reserved for electron microscopy. This may be of importance for the lithographic manufacturing of mic...

North & South American researchers find architectural abnormalities in T. cruzi ribosome

...l reconstruction of large molecules using electron microscopy and image processing. Levin told him the story of Chagas and the need to know more about the structure of the parasite's ribosome. A ribosome is basically a double ball made mostly of RNA and over 50 proteins. The balls, which are of unequal size, a...

UQ scientists break new ground in fight against infection & chronic disease

...advanced technologies at the IMB such as live cell microscopy and gene analysis, which are unique in Queensland. "By using these technologies we were able to show, for the first time, both actions occur simultaneously and a common cellular pathway is used for releasing messengers and for eating microbes," she...

Bacteria which sense the Earth's magnetic field

...ein was associated with the magnetosome chain. But microscopy made it apparent that MamJ arranges itself along a filamentous structure which trails like a string through the entire cell. In looking for this structure, the researchers used a new electron microscopic method which was developed in the Department o...

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