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Tag: "microfluidic" at biology news

Magnetic computer sensors may help study biomolecules

... The arrays might be used in chip-scale, low-power microfluidic devices for stretching and uncoiling, or capturing...e biomolecules. The NIST group is now working on a microfluidic chip that will accomplish this electronically, which would be a significant milestone for applicatio...

Sandia researchers take new approach to studying how cells respond to pathogens

...ws researchers to make sense of data obtained from microfluidic analysis and imaging Real immune cells are shor... is developing one platform with two complementary microfluidic modules -- one for trapping and imaging viable cells during stimulation with pathogens. The other co...

Applied scientists create wrinkled 'skin' on polymers

...nique has potential use for biological sensors and microfluidic devices and may offer new ways to build custom-mad... Such patterns can be used in the construction of microfluidic devices for particle separation and mixture and also have potential use in designing biosenors. The ...

Microfluidic chip helps solve cellular mating puzzle

...of the Nature article. "Through experiments with a microfluidic chip and with mathematical modeling, we were able ...ting process does not proceed as smoothly." The microfluidic chip was invented and patented by a team that included Levchenko and Paliwal, who teamed up with Ale...

Swimming 'to the left' gets bacteria upstream, and may promote infection

...ia in a flow environment, Köser's team constructed microfluidic devices using soft lithography. Inside the devices they set up various flow patterns to observe the bacteria in channels that were only 150 or 300 microns wide and between 50 and 450 microns deep. They were able to observe how the bacteria moved at ...

The power of one: A simpler, cheaper method for cell fusion

...ecise. "In my device, the narrow section in the microfluidic channel is so small that only two to three cells fit into it," Lu said. Lu said he believes that his device may be developed to have a higher throughput than current methods. Although Lu's technology currently fuses single pairs at once, it may be...

Even when faint, ovary scent draws sperm cells

...eo of the sperm during assays. "We combined in a microfluidic device the ability to generate a chemical gradient...uate sperm chemotaxis," Jacobson said. "The use of microfluidic devices appears to be an ideal approach for precisely controlling the chemical gradient and accurate...

Magnetism and mimicry of nature hold hope for better medicine, environmental safety

...arcia is among scientists and engineers developing microfluidic and test-surface techniques. The team includes Mar.... The research can accelerate the development of microfluidic devices that would, for instance, allow as many as 20 to 30 various tests to be performed using a si...

Neuronal cell cultures kept on the straight and narrow

...l layer. Even better, according to the NIST team, microfluidic channels can be used to lay down the PEM coating in patterned lines just a few micrometers wide. Neuronal cells will largely confine themselves to the pattern, enabling a variety of cell-geometry experiments, such as measuring the maximum gap between...

Berkeley researchers lay groundwork for cell version of DNA chip

...d DNA onto gold pads, which were incorporated into microfluidic chips through standard photolithography. After the DNA-coated Jurkat cells were rinsed over the chips, fluorescence microscopy revealed that only those cells coated with single-stranded DNA complementary to the anchored DNA adhered to the gold pads....

Nano machine switches between biological and silicon worlds

...arts with a DNA molecule fixed to the floor of the microfluidic channel. This strand is held upright, like a string held up by a weather balloon, by anchoring the floating end of the DNA strand to a magnetic bead, itself held up under the influence of magnetism. A specific type of protein, called a Restriction-M...

Researchers use 'trickery' to create immune response against melanoma

...This prostate cancer targeting was modeled using a microfluidic device and shown to occur under physiological fluid flow conditions that are present in systemic microvasculature, making their use after intravenous administration therapeutically relevant. The investigators also used high magnification microscopy a...

Targeted drug delivery achieved with nanoparticle-aptamer bioconjugates

...This prostate cancer targeting was modeled using a microfluidic device and shown to occur under physiological fluid flow conditions that are present in systemic microvasculature, making their use after intravenous administration therapeutically relevant. The investigators also used high magnification microscopy a...

NHGRI expands effort to revolutionize sequencing technologies

...group is to demonstrate how existing droplet-based microfluidic electro-wetting technology can be modified to perform sequencing by synthesis reaction chemistry. This method allows for smaller volumes of materials to be used as well as the decoupling of synthesis and detection steps, resulting in more efficient a...

Nanotechnology to provide portable genetic risk detection

...maly. The sample is injected into the device via a microfluidic header and the deflection of the cantilevers ?by a...m and we are due to take out a third patent on the microfluidic header, which is unique in that it uses individual inlet and outlet paths for each cantilever rather...

Microreactor efficiently regenerates cofactors for biocatalysis

...on its Web site. The microreactor uses a Y-shaped microfluidic channel in which two liquid streams (a reactant stream and a buffer stream) merge and flow laminarly between two electrodes without mixing. By adjusting the flow rates of the two streams, the researchers can focus the reactant stream close to the cat...

Life detection instrument passes key test on road to Mars

...mochirality in amino acids. These microarrays with microfluidic channels are 100 to 1,000 times more sensitive for...ompounds, as is likely to be the case on Mars, the microfluidic channels in the capillary disks don't get clogged as readily as they do when used to test samples in...

Open microfluidic and nanofluidic systems

...tments and, thus, provide a new route towards open microfluidic and nanofluidic systems. Scientists from the Max Planck Institute of Colloids and Interfaces, the Max Planck Institute of Dynamics and Selforganization and the University of California in Santa Barbara have shown that such open systems are possible i...

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