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Tag: "microenvironment" at biology news

Migration alert -- How tumor cells home in on the lymphatic system

...ered a tissue culture model of the tumor-lymphatic microenvironment and developed computational models to calculate the gradients of the signaling molecule. The study provides the first evidence that tumor cells can both produce and use the same signaling molecule, and it highlights the significance of the biophy...

100 percent of pregnant women have at least one kind of pesticide in their placenta

...umulated in the organism have direct access to the microenvironment where the embryo/foetus develops. The doctoral thesis Exposición materno-infantil vía placentaria a compuestos químicos medioambientales con actividad hormonal (Maternal-child exposure via the placenta to environmental chemical substances with horm...

Reversing cancer cells to normal cells

...lls - by exposing the tumor cells to the embryonic microenvironment of human embryonic stem cells, the zebra fish and ...receiving, Dr. Hendrix and her colleagues used the microenvironment of the zebrafish to study whether the tumor cells could communicate with the zebrafish stem cells an...

Math model predicts cancer behavior

...ter simulations of tumor growth ?suggests that the microenvironment around tumor cells determines the tumor's ultimate...ds the cells. They were surprised to find that the microenvironment around the tumor determines both the tumor's shape and its composition. "What we get is a picture ...

Does natural selection drive the evolution of cancer?

...dies suggest, too, that the fibroblasts in a tumor microenvironment begin to acquire mutations of their own. "They're co-evolving, and it becomes a dynamic, runaway process," Maley says. ...

World's smallest cancer detection device

...irectly observe cellular interactions in the tumor microenvironment of live animal models of breast cancer. By placing an artificial blood vessel near tumors, he was able to collect motile cancer cells for study and to predict--by the presence or absence of certain signaling molecules--whether the tumor cells have th...

Innovative movies show real-time immune-cell activity within tumors

...ation and engagement directly within the intricate microenvironment of tumors." The scientists used a leading-edge i...of the individual cellular components of the tumor microenvironment in real-time. Second, we have demonstrated that T cells physically interact with tumor cells, which ...

MIT creates 3-D scaffold for growing stem cells

...w synthetic structure can provide a more conducive microenvironment for tissue cell cultures and tissues used in regenerative medicine, such as skin grafts or neurons to replace brain cells lost to injury or disease. The scaffold itself can be transplanted directly into the body with no ill effects. "The time has...

Expanding waistlines triggered by your genes

... culture is different from three-dimensional (3-D) microenvironment taking place inside the complex body. In regular 2-D culture system, the MT1-MMP gene was not necessary, but it becomes a critical metabolic scissors once cells are inside 3-D environment either in collagen gel or in the real tissue of mouse. This fi...

Adult stem cells are touchy-feely, need environmental clues

...the Penn researchers have proven that the physical microenvironment is also crucial for guiding the cells through diff...their chemical environment." But, the physical microenvironment can change due to injury and also in disease, which would make it difficult to use these stem cells ...

Macrophage signaling may affect hormone resistance in prostate tumors

...l signaling from macrophages in the prostate tumor microenvironment might affect hormone resistance.Using cell biology methods, they discovered a mechanistic explanation for at least one form of resistance to androgen antagonists. "It was of particular interest for us to determine whether a macrophage/prostate canc...

Researchers reveal lung's unique innate immune system

...sed in the lung by epithelial cells. "Because the microenvironment of the alveola is a delicate one, it would be damaged if the macrophage immune system was in a constant battle-ready status," said Raz. "This could readily lead to the type of inflammation we see in autoimmune diseases of the lung such as asthma." ...

New technique helps researchers determine amino-acid charge

...in a detailed picture of the effect of the protein microenvironment on the affinity of ionizable amino-acid residues f...r thing is the affinity for protons in the complex microenvironment presented by a membrane protein," Grosman said. "For the first time, we were able to measure proton-...

Cancer support cells may evolve, fuel tumor growth, study shows

...ll-to-cell interactions and the changing selective microenvironment that drives cancer development. ...

Model identifies genes that induce normal skin cells to become abnormal

...ows scientists to observe how interacting with the microenvironment of metastatic melanoma cells induces normal skin c... new insights into the influence of the tumor cell microenvironment on the transformation of normal skin cells, as well as on genetic triggering mechanisms and signalin...

Stem cell microenvironment reverses malignant melanoma

...l utility of isolating the factors within the hESC microenvironment responsible for influencing tumor cell fate and re...nique, three-dimensional model to test whether the microenvironment supporting human embryonic stem cells (hESCs) would influence the behavior of human metastatic melan...

Most common lung cancers may begin in newly discovered cells

...Kim and her colleagues do not yet know the optimal microenvironment for stem cells of the lung, including the roles of the neighboring cells that support the stem cells and specialized lung cells. Still, she says their studies are as rigorous as the generally accepted reports of stem cells found in the skin, brain, t...

Study of genomic DNA leads to new advances in cancer diagnostics

...ike know that how a cancer cell interacts with its microenvironment is important for cancer progression. Such interact... found that the extracellular matrix (ECM), or the microenvironment surrounding the cell, influenced whether the cell's chromatin was sensitive or resistant to Alu I. T...

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